Dermatology

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Article Dermatology

Could red and near-infrared emitting fabric technology improve the severity of psoriasis, polymorphous light eruption, and alopecia areata?

Jessica N. Pixley, Rithi J. Chandy, Irma Richardson, Joseph L. Jorizzo, Steven R. Feldman

Summary: This pilot study assessed the efficacy of a red/near-infrared (NIR)-emitting fabric for psoriasis, polymorphous light eruption (PMLE), and alopecia areata (AA). The results showed that the red/NIR-emitting fabric can improve the disease severity of psoriasis, PMLE, and limited AA. However, the limitations of this study include the continuation of other medications and a small sample size.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Certolizumab treatment of localized pyoderma gangrenosum in a pregnant patient

Na Wang, Changping Yu, Weiwei Wang, Qing Yang

Summary: Pyoderma gangrenosum (PG) is an inflammatory disease characterized by ulcerating neutrophilic dermatosis, affecting 3-10 patients per million. It equally affects both genders and all age groups. Typically occurring in the lower extremities, minor skin trauma can lead to the development of new lesions. Patients experience chronic, nonhealing ulcers with accompanying pain. Despite the lack of an official treatment protocol, systemic or intralesional corticosteroids, as well as biologic agents like TNF-alpha inhibitors, have shown some success. However, selecting appropriate drugs for pregnant patients can be challenging.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Review Dermatology

Systematic review of mesotherapy: a novel avenue for the treatment of hair loss

Aditya K. Gupta, Shruthi Polla Ravi, Tong Wang, Mesbah Talukder, Michela Starace, Bianca Maria Piraccini

Summary: This systematic review summarizes 27 articles out of 416 records on the efficacy of mesotherapy for the treatment of hair loss, providing an overview of the observed results. Although several studies report significant improvements in hair growth after treatment, there is a lack of standardized regimens. Further large-scale and controlled clinical trials are needed to evaluate the utility of mesotherapy for hair loss disorders.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient

Shiyu Zhang, Lu Lu, Jindi Feng, Zhonghui Hu, Hongbin Song, Lu Yang, Yuehua Liu, Di Chen, Tao Wang

Summary: In this article, a case of a 28-year-old female with atopic dermatitis who developed uveitis and hypereosinophilia after starting dupilumab treatment is reported. The uveitis improved with reduced dose and the hypereosinophilia gradually relieved without discontinuation of dupilumab. The authors share their experience in managing these conditions and suggest that discontinuation of dupilumab may not always be necessary.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Fixed-combination halobetasol propionate and tazarotene topical lotion decreases TNF-& alpha; and IL-17A levels in psoriatic lesions

Zoe Diana Draelos, Matthew M. Draelos, Tina Lin, Abby Jacobson

Summary: This study investigated the efficacy of fixed-combination halobetasol propionate and tazarotene lotion in reducing TNF-a and IL-17A levels in psoriasis plaques. The results showed that the treatment significantly improved psoriasis and effectively reduced cytokine-associated inflammatory markers.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Review Dermatology

Ocular side effects of systemic isotretinoin - a systematic review and summary of case reports

Olivia Lamberg, Arianna Strome, Foster Jones, Julia Mleczek, Adrienne Jarocki, Jonathon P. Troost, Yolanda Helfrich

Summary: This study provides a systematic meta-analysis of ocular side effects during isotretinoin use and summarizes the corresponding incidences. It also presents a narrative summary based on case reports. The most commonly reported ocular side effect is dry eye, while other less common but more serious side effects include vision changes. However, there is considerable heterogeneity in the reported incidences of ocular side effects between studies.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Efficacity of dupilumab in severe idiopathic cold urticaria: a case report

Valentine Marchal, Ziad Reguiai

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Retraction Dermatology

撤稿声明: Secukinumab-induced paradoxical skin lesions, but successful treatment with tofacitinib in SAPHO syndrome: a case report (Retraction of March, 2023)

Li Luan, Chengzhi Lv

Summary: SAPHO syndrome is a rare autoinflammatory disorder without standardized therapy. IL-17 inhibitors have been effective in individual cases, but may also cause paradoxical skin lesions. We describe a patient who developed such lesions after treatment with secukinumab, but achieved rapid remission with tofacitinib.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Occurrence of adverse events associated with the initiation of methotrexate and biologics for the treatment of psoriasis in routine clinical practice

Faizan Mazhar, Asa Krantz, Lovisa Schalin, Josefin Lysell, Juan Jesus Carrero

Summary: This study suggests that compared to biologics, treatment with methotrexate for psoriasis patients is associated with a higher risk of anemia and liver adverse events, but similar risks of kidney, serious infections, and major gastrointestinal adverse events.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Intramuscular ertapenem for the treatment of severe cases hidradenitis suppurativa

Juan Segura M. Palacios, Alberto Soto Moreno, Ismael Valladares Millan, Francisco Rivas Ruiz, Carlos Cuenca Barrales, Alejandro Molina Leyva

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Anti-IL-23 and anti-IL-17 drugs for the treatment of non-pustular palmoplantar psoriasis: a real-life retrospective study

Luciano Ibba, Luigi Gargiulo, Angela Alfano, Ruggero Cascio Ingurgio, Antonio Costanzo, Mario Valenti, Alessandra Narcisi

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Baricitinib provides rapid and sustained improvements in absolute EASI and SCORAD outcomes in adults with moderate-to-severe atopic dermatitis

Jacob P. Thyssen, Thomas Bieber, C. Elise Kleyn, Audrey Nosbaum, Susanne Grond, Helmut Petto, Elisabeth Riedl, Andreas Wollenberg

Summary: This study evaluated the efficacy of the oral selective Janus kinase 1/2 inhibitor Baricitinib in treating atopic dermatitis (AD). The results showed that Baricitinib significantly improved skin lesions and disease severity in patients with moderate-to-severe AD over a 16-week period, and also had a positive impact on their quality of life.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Treatment of generalized granuloma annulare with dupilumab

Xiaoting Song, Zirui Chen, Zuotao Zhao, Aiping Wang

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Adipose-derived stem cell exosomes for treatment of dupilumab-related facial redness in patients with atopic dermatitis

Hye Sung Han, Young Gue Koh, Jun Ki Hong, Yoon Jin Roh, Seong Jun Seo, Kui Young Park

Summary: This study evaluated the efficacy and safety of a topical formulation containing human adipose tissue-derived mesenchymal stem cell-derived exosomes (ASCEs) in the treatment of DFR. The results showed that ASCEs can alleviate DFR by downregulating local inflammation and restoring skin barrier function.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Efficacy of autologous platelet-rich plasma therapy versus topical Minoxidil in men with moderate androgenetic alopecia: a randomized open-label trial

Mithinkumar Balasundaram, Rashmi Kumari, Sivaranjini Ramassamy

Summary: This study compared the efficacy and safety of PRP and minoxidil in men with moderate grades of androgenetic alopecia. The results showed that both PRP and minoxidil significantly increased hair count and density in the target area, but the difference between the two was not significant. Adverse events occurred more frequently in the PRP group. Therefore, PRP is effective in treating moderate grades of androgenetic alopecia in men, but may not be different from minoxidil.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Five-year safety of tildrakizumab in patients with moderate-to-severe psoriasis from two phase 3 trials (reSURFACE 1 and reSURFACE 2): number needed to harm for occurrence of adverse events of special interest

Alexander Egeberg, Denis Jullien, Kristian Gaarn Du Jardin, Diamant Thaci

Summary: This study presents the 5-year safety data of tildrakizumab, which is represented as EAIRs of events per 100 patient-years of exposure. The safety profile of tildrakizumab was comparable to that of PSOLAR, and the NNH for AESI with tildrakizumab were very high or negative due to lower event rates.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Successful treatment of rare linear lichen planopilaris with Ixekizumab

Hanof Ahmed, Mahir Petkar, Martin Steinhoff

Summary: Lichen planopilaris (LPP) is a lymphocytic primary cicatricial alopecia characterized by perifollicular erythema, follicular hyperkeratosis, and scarring that result in permanent hair loss. Current treatments fail to achieve satisfactory and consistent results, leading to long-term disfigurement and psychological burden for patients with LPP.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Safety of baricitinib for the treatment of atopic dermatitis over a median of 1.6 years and up to 3.9 years of treatment: an updated integrated analysis of eight clinical trials

Thomas Bieber, Norito Katoh, Eric L. Simpson, Marjolein de Bruin-Weller, Diamant Thaci, Antonio Torrelo, Angelina Sontag, Susanne Grond, Maher Issa, Xiaoyu Lu, Tracy Cardillo, Katrin Holzwarth, Jacob P. Thyssen

Summary: Baricitinib demonstrated a consistent safety profile in the long-term treatment of atopic dermatitis patients, with no new safety signals identified. The incidence rates of major adverse cardiovascular events, deep vein thromboses/pulmonary emboli, malignancies, and serious infections were within the ranges observed in the background population of patients with AD.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons

Qi Yin, Frank B. B. Niessen, Susan Gibbs, Oren Lapid, Juliette M. I. Louter, Paul P. M. Van Zuijlen, Albert Wolkerstorfer

Summary: A wide variety in intralesional corticosteroid administration for keloids is noted among dermatologists and plastic surgeons in the Netherlands, even when evidence points toward an optimal way of treatment. Future studies and better implementation of existing evidence may reduce variation and optimize treatment results.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Topical prebiotics/postbiotics and PRURISCORE validation in atopic dermatitis. International study of 396 patients

Carlo Gelmetti, Corinna Rigoni, Alessandra Maria Cantu, Antonina Agolzer, Alice Agrusa, Michela Brena, Federica Dall'Oglio, Patrizia Demichelis, Sandra Farina, Lucretia Adina Frasin, Sandra Lorenzi, Giuseppina Mazzola, Marisa Pratico, Stefania Robotti, Aurora Tedeschi, Lucia Villa, Prodromos Ananiadis, Eirini Arkoumani, Iulia Astashonok, Eulalia Baselga Torres, Sidita Borici, Elna Cano, Rozana Cela, Amarda Cengo, Francisca Corella, Xavier Cubiro Raventos, Miriam America De Jesus Silva, Ermira Demiraj, Entela Dhima, Xhiljola Doci, Anna Domarad, Marina Didyk, Albana Dyli, Ourania Efthimiou, Georgia Filippi, Victor-Adrian Flores Climente, Maria Pilar Garcia Muret, Javier Garcia Navarro, Migena Gega, Aristea Noura Giakoub, Vasileios Giakoubis, Amarda Gica, Marjeta Gjomema, Blerina Guri, Elmijola Janushaj, Antonios Kanelleas, Georgia Kanelopoulou, Entela Kapaj, Dorothea Kapoukranidou, Konstantina Karadima, Athina Katsavou, Lena Kotrulja, Aikaterini Kyriakou, Georgios Larios, Anna Lopez, Cristina Lopez, Sofia Magdalini Manoli, Tatiana Matvienko, Liljana Mervic, Konstantinos Mileounis, Diana Muja, Milkota Nadezhda, Despoina Panagioti, Markos Papakonstantis, Maria Papanikou, Despoina Papathemeli, Kyriaki Papigkioti, Violetta Pivak, Driada Preza, Esther Roe, Mirjam Rogl Butina, Esther Serra Baldrich, Dimitrios Sgouros, Aleksandra Shilova, Eljona Shllaku, Nikolaos Sideris, Ermal Sina, Ardiana Sinani, Fani Sourli-Chasioti, Mirsa Stankaj, Dimitra Tasioula, Athanasios Tsalmadoupis, Fragkiski Tsatsou, Eftichia Tsenebi, Anastasia Tsitlakidou, Politimos Vassis, Eva Vilarrassa, Olga Vorobey, Nikolaos Voutsakis, Svetlana Yakovleva, Svetlana Yakubovskaya, Ekaterina Yerygina, Alexios Zarras, Valbona Zenelaj, Olga Zenko

Summary: This study aimed to investigate the efficacy and tolerability of a cream containing a mixture of prebiotics and postbiotics, and validate the PRURISCORE itch scale for managing atopic dermatitis. The results showed that the cream demonstrated good efficacy and tolerability in all age groups, with significant decreases in SCORAD, PRURISCORE, and IGA scores over the course of the study. The majority of patients preferred using PRURISCORE over the VAS scale.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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