Dermatology

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Article Dermatology

Neurotensin counteracts hair growth inhibition induced by chronic restraint stress

Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou

Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.

EXPERIMENTAL DERMATOLOGY (2024)

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Article Dermatology

A deep learning algorithm to detect cutaneous squamous cell carcinoma on frozen sections in Mohs micrographic surgery: A retrospective assessment

Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy

Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.

EXPERIMENTAL DERMATOLOGY (2024)

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Review Dermatology

A comprehensive review of platelet-rich plasma for the treatment of dermatologic disorders

Jessica N. Pixley, Madison K. Cook, Rohan Singh, Jorge Larrondo, Amy J. McMichael

Summary: Platelet-rich plasma (PRP) provides anti-inflammatory and regenerative properties through angiogenesis, cell differentiation, and proliferation. Although its efficacy is not well-understood, PRP has shown potential in treating dermatologic conditions such as hair loss, vitiligo, nonhealing wounds, photoaging, and acne scars.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

A prospective randomized controlled trial of Psychodermatology on the efficacy of Rilastil Difesa Sterile & REG; cream in the hand eczema of healthcare workers during the COVID-19 pandemic

Federica Veronese, Elia Esposto, Chiara Airoldi, Carla Gramaglia, Lucia Bestagini, Elisa Zavattaro, Patrizia Zeppegno, Paola Savoia

Summary: This study is a Randomized Control Trial (RCT) evaluating the effectiveness of an emollient and rehydrating topical product in healthcare workers with hand eczema during the COVID-19 pandemic. The data showed that patients treated with the tested product had greater reductions in clinical and psychological scores compared to those treated with a basic cream. The study also confirmed the connection between dermatological and psychological indicators.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Effectiveness and safety of ustekinumab for the treatment of psoriasis; six years of clinical experience

Melis Gonulal, Didem Didar Balci, Aylin Ozturk, Sinan Dogan

Summary: This study investigated the long-term clinical experience with ustekinumab in psoriasis cases. It was found that ustekinumab was effective for non-naive and resistant patients. Male patients showed more rapid and robust responses to the drug, and patients were more willing to continue the treatment.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Review Dermatology

Efficacy and safety evaluations of adalimumab biosimilars in the treatment of psoriasis

Changkun Li, Yixuan Sunhe, Hui Zhou, Weihua Dong

Summary: This study systematically evaluated the efficacy and safety of adalimumab biosimilar agents in the treatment of moderate-to-severe plaque psoriasis, providing evidence-based reference data for clinical practice. The results showed that there were no significant differences in the response rates and adverse events between adalimumab biosimilar agents and their reference agents after 16 weeks of treatment. Therefore, adalimumab biosimilar agents have a comparable overall efficacy and safety profile for psoriasis compared to their reference agents.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics

Jingwen Cui, Xiaomei Zhang, Jingwen Deng, Yuhong Yan, Danni Yao, Hao Deng, Jingjie Yu, Shuyan Ye, Ling Han, Xiaobo Yu, Chuanjian Lu

Summary: In this study, we analyzed the response to topical sequential therapy for psoriasis and identified four biomarkers. We also found that topical sequential therapy may alleviate psoriasis by regulating lipid metabolism and modulating the immune response by affecting the complement activation process.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

The economic burden and quality of life of patients with psoriasis treated with biologics in China

Shuhui Min, Danfeng Wang, Jiali Xia, Xiao Lin, Guan Jiang

Summary: This study investigates the economic cost, quality of life, and patient satisfaction of individuals with psoriasis treated with biologics and non-biologics in China. The results show that patients in the biologic group experience a higher economic burden and better quality of life.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Unlocking potential: clinical benefits of enlarging the nail bed explored through continuous W-shaped incisions

Yaxin Xue, Zijing Du, Chao Du, Jiajun Fan, Jia Xu, Xin Li, Hao Lv, Yi Cao, Dong Han

Summary: This study introduces a novel technique for nail bed expansion and evaluates its effects in patients with nail bed atrophy. The surgical group underwent continuous W-shaped incisions, resulting in significant increases in nail bed height, width, and area, as well as improved esthetics of the newly-formed nail plate compared to the control group.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

A 52-week multicenter retrospective real-world study on effectiveness and safety of dupilumab in children with atopic dermatitis aged from 6 to 11 years

Cataldo Patruno, Gabriella Fabbrocini, Giuseppe Lauletta, Valeria Boccaletti, Cristiana Colonna, Riccardo Cavalli, Iria Neri, Michela Ortoncelli, Donatella Schena, Luca Stingeni, Katharina Hansel, Vincenzo Piccolo, Veronica Di Brizzi, Concetta Potenza, Ersilia Tolino, Luca Bianchi, Sara Manti, Rocco De Pasquale, Vito Di Lernia, Lucia Caminiti, Elena Galli, Paola Coppo, Andrea Chiricozzi, Clara De Simone, Cristina Guerriero, Fabrizio Giuseppe Amoruso, Eugenio Provenzano, Salvatore Leonardi, Amelia Licari, Gian Luigi Marseglia, Antonino Palermo, Sabrina Di Pillo, Daniele Russo, Viviana Moschese, Vincenzo Patella, Tiziana Peduto, Caterina Ferreli, Paola Zangari, Federica Veronese, Samantha Federica Berti, Michaela Gruber, Elena Pezzolo, Stefania Termine, Rosanna Satta, Federica Dragoni, Maria Esposito, Maria Concetta Fargnoli, Paolo Chiodini, Ylenia Vallone, Francesca di Vico, Vincenzo Picone, Maddalena Napolitano

Summary: This study aimed to evaluate the efficacy and safety of dupilumab in treating moderate-to-severe atopic dermatitis (AD) in children aged 6-11 years over a 52-week period. The results showed that dupilumab significantly improved the disease severity in these children and maintained this improvement over time at week 16, 24, and 52.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Review Dermatology

Effects and safety of fire needle adjuvant chemical peels therapy in acne vulgaris: a systematic review and meta-analysis

Jianfeng Zhang, Peng Lin, Chenqi Guo, Cong Ma, Yiting Liu, Yingdong Wang, Yu Zhang

Summary: Fire needle adjuvant chemical peels therapy is effective and safe for acne vulgaris, improving the total effective rate and skin lesions, while reducing the recurrence rate. The application of fire needle is associated with few adverse reactions that are well tolerated and transient. However, more large-scale, well-designed clinical studies are needed for evidence-based medical support.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Review Dermatology

Expert opinion on management of moderate-to-severe atopic dermatitis in Qatar

Martin Steinhoff, Mehdi Adeli, Hassan Riad, Mohamed Allam, Ahmad Hazem, Ra'ed Alsmadi, Adel Mohamed Kamal, Waad Ibrahim, Maryam Ali Al-Nesf

Summary: Atopic dermatitis (AD) is a chronic-relapsing inflammatory skin disorder characterized by intense itching and eczematous lesions that have a negative impact on quality of life. Guidelines for managing moderate-to-severe AD in Qatar have been developed by a panel of experts using the Delphi technique. These guidelines offer a comprehensive and pragmatic approach to assist healthcare professionals in making clinical decisions in Qatar.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

SARS-CoV-2: an environmental trigger of Darier's disease?

Diego Orsini, Andrea D'Arino, Flavia Pigliacelli, Paolo Iacovelli, Alessia Pacifico, Carlo Cota, Monia Di Prete, Fabio Stefano Maramao

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Scalp hair regrowth is associated with improvements in health-related quality of life and psychological symptoms in patients with severe alopecia areata: results from two randomized controlled trials

Bianca Maria Piraccini, Manabu Ohyama, Brittany Craiglow, Anthony Bewley, Yuxin Ding, Yun-Fei Chen, Yves Dutronc, Evangeline Pierce, Frederick Durand, Arash Mostaghimi

Summary: This study analyzed the association between scalp hair regrowth and improvements in health-related quality of life and psychological burden in patients with severe alopecia areata. The results showed that patients with meaningful hair regrowth experienced greater improvements in overall well-being and reduced anxiety and depression.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Acrodermatitis continua of Hallopeau in an elderly patient successfully and rapidly treated with risankizumab: a case report

Diego Orsini, Paolo Iacovelli, Pasquale Frascione, Alessia Pacifico

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

The role of biopsy in the management of patients with delusions of parasitosis: a retrospective chart review

Nancy W. W. Shen, Jon B. B. Suzich, Abby C. C. Wills, Richard H. H. Flowers

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Schnitzler syndrome refractory to anakinra: successful treatment with canakinumab

Angel Luis Salcedo-Mingoarranz, Maria Dorado-Fernandez, Sofia Garcia-Martinez, Paz Collado-Ramos, Nicolas Silvestre-Torner

Summary: Schnitzler syndrome (SchS) is a rare autoimmune and inflammatory disease mediated by interleukin-1 beta (IL-1β). Diagnosis requires recurrent monoclonal gammopathy and chronic urticarial rash according to the Strasbourg criteria. Treatment with canakinumab has been successful in a case of SchS after intolerance to anakinra and failure of other therapies. Canakinumab, an anti-IL-1β antibody, has proven to be an effective alternative to anakinra in SchS.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Comparative effectiveness among available treatments in difficult-to-treat port-wine stains (PWS): a Network Meta-Analysis of observational evidence

Sirinda Jamjanya, Voraphol Vejjabhinanta, Krittai Tanasombatkul, Phichayut Phinyo

Summary: In this study, the comparative effectiveness among treatments for difficult-to-treat port-wine stains was evaluated. The results suggest that intense pulsed light (IPL) and 585 nm long-pulsed dye laser (LPDL) may be more effective than 585 nm short-pulsed dye laser (SPDL). Further clinical trials are needed to confirm these findings.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Oral roflumilast as a therapeutic option for psoriasis, what role does it have? Case report and literature review

Javier Gimeno Castillo, Francisco Javier de la Torre Gomar, Aida Menendez Parron, Zurine Martinez de Lagran Alvarez de Arcaya

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Experiences and coping behaviors of patients with psoriasis: a qualitative study

Lin-Lin Lee, An-Ping Huo, Shu-Ling Chen

Summary: This qualitative study aimed to explore the experiences and coping behaviors of patients with psoriasis. Through semi-structured interviews, 20 patients with psoriasis from a regional teaching hospital in Taiwan were recruited. The results showed that patients experienced physical and psychological distress, but managed the disease through different coping strategies.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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