Critical Care Medicine

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Article Critical Care Medicine

Impact of Preexisting Depression and Anxiety on Hospital Readmission and Long-Term Survival After Cardiac Arrest

Patrick J. Coppler, Mckenzie Brown, Darcy M. Moschenross, Priya R. Gopalan, Alexander M. Presciutti, Ankur A. Doshi, Kelly N. Sawyer, Adam Frisch, Clifton W. Callaway, Jonathan Elmer

Summary: This study investigated the prevalence of psychiatric conditions in cardiac arrest patients who survived hospital discharge and found that depression is an independent risk factor for hospital readmission.

JOURNAL OF INTENSIVE CARE MEDICINE (2023)

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Article Critical Care Medicine

The Microbiome and Metabolome of the Gut of Children with Sepsis and Septic Shock

Jhuma Sankar, Vaishali Thakral, Kanchan Bharadwaj, Sheetal Agarwal, Sushil Kumar Kabra, Rakesh Lodha, Sumit Rathore

Summary: There are significant alterations in the gut microbiota and metabolome in children with sepsis/septic shock. Further research is needed to confirm these findings and develop potential therapeutic targets that will improve outcomes in children with sepsis/septic shock.

JOURNAL OF INTENSIVE CARE MEDICINE (2023)

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Article Critical Care Medicine

Interobserver reliability for manual analysis of sidestream darkfield videomicroscopy clips after resizing in ImageJ

Raushan C. B. Lala, Ryan A. P. Homes, Jeffrey Lipman, Mark J. Midwinter

Summary: The study introduces a method for capturing microcirculatory clips using current hardware that are compatible with older versions of manual analysis software. Results showed that resizing clips did not significantly affect image quality. There was marked bias between manual and automated analysis, with a linear relationship between the differences in the analyses and the magnitude of the measured parameter.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2023)

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Review Critical Care Medicine

Do critical illness survivors with multimorbidity need a different model of care?

Jonathan Stewart, Judy Bradley, Susan Smith, Joanne Mcpeake, Timothy Walsh, Kimberley Haines, Nina Leggett, Nigel Hart, Danny Mcauley

Summary: There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous research has found little benefit in rehabilitation interventions, and it is now recognized that a person's existing health status, particularly multimorbidity and frailty, strongly influences their long-term outcomes. This review explores the complex relationships between multimorbidity and patient outcomes after critical illness, and proposes potential strategies to optimize patient recovery by addressing various factors including medical conditions, treatment burden, functional status, healthcare delivery, and social support. Providing patient-centered care that proactively identifies critical illness survivors with multimorbidity and meets their unique challenges and needs is crucial for facilitating recovery and improving outcomes.

CRITICAL CARE (2023)

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Article Critical Care Medicine

Whole blood transcriptomics identifies subclasses of pediatric septic shock

Jamie O. Yang, Matt S. Zinter, Matteo Pellegrini, Man Yee Wong, Kinisha Gala, Daniela Markovic, Brian Nadel, Kerui Peng, Nguyen Do, Serghei Mangul, Vinay M. Nadkarni, Aaron Karlsberg, Dhrithi Deshpande, Manish J. Butte, Lisa Asaro, Michael Agus, Anil Sapru

Summary: Two subclasses of pediatric septic shock patients were identified through genome-wide expression profiling based on whole blood RNA sequencing, with major biological and clinical differences.

CRITICAL CARE (2023)

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Article Critical Care Medicine

Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial

Quirin Notz, Daren K. Heyland, Zheng-Yii Lee, Johannes Menger, Johannes Herrmann, Thilo S. Chillon, Stephen Fremes, Siamak Mohammadi, Gunnar Elke, C. David Mazer, Aileen Hill, Markus Velten, Sascha Ott, Maren Kleine-Brueggeney, Patrick Meybohm, Lutz Schomburg, Christian Stoppe

Summary: This study aimed to investigate the effects of selenium treatment in high-risk cardiac surgery patients and found that patients with increased GPx3 activity may benefit from selenium treatment.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2023)

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Review Critical Care Medicine

Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis

Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu, Lui G. Forni

Summary: Our meta-analysis of 11 observational studies with 3969 patients showed that proenkephalin A 119-159 (PENK) has significant potential as a biomarker for early detection of acute kidney injury (AKI), with a cutoff value of 57.3 pmol/L. The overall sensitivity and specificity of PENK in identifying AKI were 0.69 (95% CI 0.62-0.75) and 0.76 (95% CI 0.68-0.82), respectively. The combined positive likelihood ratio (LR) was 2.83 (95% CI 2.06-3.88), and the negative LR was 0.41 (95% CI 0.33-0.52). The summary receiver operating characteristic (SROC) curve demonstrated a pooled diagnostic accuracy of 0.77 (95% CI 0.73-0.81). Interestingly, patients with a history of hypertension or heart failure showed lower specificity of PENK in correlating with the development of AKI.

CRITICAL CARE (2023)

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Review Critical Care Medicine

Pathophysiological implications of ventriculoarterial coupling in septic shock

Michael R. Pinsky, Fabio Guarracino

INTENSIVE CARE MEDICINE EXPERIMENTAL (2023)

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Letter Critical Care Medicine

Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation

Keibun Liu, Mohan Gurjar, Ricardo Kenji Nawa, Chi Ryang Chung, Kensuke Nakamura

JOURNAL OF INTENSIVE CARE (2023)

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Review Critical Care Medicine

Right Ventricular Dysfunction on Transthoracic Echocardiography and Long-Term Mortality in the Critically Unwell: A Systematic Review and Meta-Analysis

Benjamin Gerhardy, Shanthosh Sivapathan, Emma Bowcock, Sam Orde, Lucy Morgan

Summary: This study found that right ventricular dysfunction (RVD) in critically ill patients is associated with increased long-term mortality, regardless of the underlying cause. The use of echocardiographic definitions of RVD showed significant heterogeneity, contributing to uncertainty in the data set.

JOURNAL OF INTENSIVE CARE MEDICINE (2023)

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Article Critical Care Medicine

Predicting extubation in patients with traumatic cervical spinal cord injury using the diaphragm electrical activity during a single maximal maneuver

Rui Zhang, Xiaoting Xu, Hui Chen, Jennifer Beck, Christer Sinderby, Haibo Qiu, Yi Yang, Ling Liu

Summary: The study evaluated whether the change of EAdi during a single maximal maneuver can predict extubation outcomes in patients with traumatic cervical spinal cord injuries. The results showed that the increase of EAdi from baseline to single maximal maneuver is associated with successful extubation.

ANNALS OF INTENSIVE CARE (2023)

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Article Critical Care Medicine

Application of Delayed Contrast Extravasation Magnetic Resonance Imaging for Depicting Subtle Blood-Brain Barrier Disruption in a Traumatic Brain Injury Model

Sigal Liraz Zaltsman, Shirley Sharabi, David Guez, Diann Daniels, Itzik Cooper, Chen Shemesh, Dana Atrakchi, Orly Ravid, Liora Omesi, Daniel Rand, Abigail Livny, Michal Schnaider Beeri, Yael Friedman-Levi, Esther Shohami, Yael Mardor, David Last

Summary: The blood-brain barrier (BBB) is often damaged after traumatic brain injury (TBI) and can lead to long-term complications. Detecting subtle BBB disruption (BBBd) in the chronic phase of TBI is challenging. This study used a new imaging technique, delayed contrast extravasation MRI (DCM), to reveal long-term BBBd up to 1.5 years after TBI, providing valuable insights into the dynamics of BBBd post-TBI.

JOURNAL OF NEUROTRAUMA (2023)

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Article Critical Care Medicine

Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study

Louise Baucher, Virginie Lemiale, Adrien Joseph, Florent Wallet, Marc Pineton de Chambrun, Alexis Ferre, Romain Lombardi, Laura Platon, Adrien Contejean, Charline Fuseau, Laure Calvet, Frederic Pene, Achille Kouatchet, Djamel Mokart, Elie Azoulay, Antoine Lafarge

Summary: This study investigated the features and outcomes of severe infections requiring intensive care unit (ICU) admission in patients receiving Ibrutinib treatment. The results showed that invasive fungal infections were the most common severe infections, and a high percentage of patients required mechanical ventilation during treatment, leading to poor prognosis.

ANNALS OF INTENSIVE CARE (2023)

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Article Critical Care Medicine

Critical illness among patients experiencing homelessness: a retrospective cohort study

K. M. Sauro, C. M. O'Rielly, J. Kersen, A. Soo, S. M. Bagshaw, H. T. Stelfox

Summary: This study aimed to compare the epidemiology and healthcare use of critically ill patients experiencing homelessness to those with stable housing. The results showed that homelessness was associated with younger age, more admissions for medical reasons, and fewer comorbidities. While the processes of care in the ICU were similar, patients experiencing homelessness had higher healthcare resource use after ICU, including more visits to the emergency department, hospital readmissions, and longer hospital stays. These findings highlight the need for strategies to reduce healthcare resource use among critically ill patients experiencing homelessness.

CRITICAL CARE (2023)

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Article Critical Care Medicine

Characteristics and prognostic factors of bacterial meningitis in the intensive care unit: a prospective nationwide cohort study

Nora Chekrouni, Merel Kroon, Evelien H. G. M. Drost, Thijs M. van Soest, Merijn. W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek

Summary: This study investigated the clinical features and prognostic factors of adults with bacterial meningitis admitted to the intensive care unit. The majority of patients required ICU admission, and the rates of unfavorable outcome and mortality were high.

ANNALS OF INTENSIVE CARE (2023)

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Letter Critical Care Medicine

Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients

Patrick M. Honore, Emily Perriens, Sydney Blackman

CRITICAL CARE (2023)

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Review Critical Care Medicine

Targeting the host response in sepsis: current approaches and future evidence

Christian Bode, Sebastian Weis, Andrea Sauer, Pedro Wendel-Garcia, Sascha David

Summary: This article explores the immune dysregulation in sepsis and studies on treatment methods targeting the host response, as well as discusses the future prospects of precision medicine approaches in sepsis.

CRITICAL CARE (2023)

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Article Critical Care Medicine

Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases

Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong

Summary: This study evaluated the outcomes of OHCA patients with initial shockable rhythm in Singapore and Osaka, and found that the outcomes for patients without prehospital ROSC in Singapore were worse than expected based on Osaka data, even when using population-based databases.

CRITICAL CARE (2023)

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Review Critical Care Medicine

Prolonged vs intermittent intravenous infusion of β-lactam antibiotics for patients with sepsis: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis

Xiaoming Li, Yi Long, Guixin Wu, Rui Li, Mingming Zhou, Aiting He, Zhengying Jiang

Summary: This systematic review and meta-analysis found that prolonged intravenous infusion of beta-lactam antibiotics in patients with sepsis was associated with a significant reduction in all-cause mortality within 30 days, as well as lower hospital mortality, ICU mortality, and higher clinical cure. However, the certainty of the evidence was low and more studies are needed to confirm the results.

ANNALS OF INTENSIVE CARE (2023)

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Article Critical Care Medicine

Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study

Hui Li, Xiaojun Pan, Sheng Zhang, Xuan Shen, Wan Li, Weifeng Shang, Zhenliang Wen, Sisi Huang, Limin Chen, Xu Zhang, Dechang Chen, Jiao Liu

Summary: The study suggests that there is a correlation between autoimmune diseases and the occurrence of sepsis, but no causal relationship between autoimmune diseases and 28-day mortality from sepsis. Sepsis may increase the risk of developing psoriasis.

CRITICAL CARE (2023)

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