Article
Clinical Neurology
Jalil Rasgado-Toledo, Sai Siddharth Duvvada, Apurva Shah, Madhura Ingalhalikar, Vinoo Alluri, Eduardo A. Garza-Villarreal
Summary: This study compared the structural and functional brain networks between patients with cocaine use disorder (CUD) and healthy controls using multimodal fusion. The findings revealed abnormal brain connectivity in CUD patients, and the multimodal fusion method provided more information about brain regions affected by cocaine abuse.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yiming Meng, Jing Sun, Guirong Zhang
Summary: Fecal microbiota transplantation (FMT) has emerged as a promising therapy for major depressive disorder (MDD), with the goal of restoring a healthy gut microbiota to alleviate symptoms. While it has shown encouraging results, there are potential hazards and limits to consider.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amira Abozaid, Robert Gerlai
Summary: This study investigates associative learning in zebrafish by manipulating feeding frequency and using conditioned stimuli. The results show that zebrafish fed five times a day perform better in training and consume less food compared to those fed once a day. Chronic elevated feeding improves food consumption and enhances learning and memory performance in adult zebrafish without affecting activity levels.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Meysam Amidfar, Gholamreza Askari, Yong-Ku Kim
Summary: The discovery of biomarkers and the application of metabolomics can be useful for diagnosing and treating Alzheimer's disease and mild cognitive impairment, while investigating the relationship between nutritional behavior and Alzheimer's disease can provide preventive strategies against cognitive decline and dementia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zerui You, Chengyu Wang, Xiaofeng Lan, Weicheng Li, Dewei Shang, Fan Zhang, Yanxiang Ye, Haiyan Liu, Yanling Zhou, Yuping Ning
Summary: This study reveals the metabolic differences between patients with treatment-resistant depression (TRD), first-episode drug-naive major depressive disorder (DN-MDD), and healthy controls (HCs), and identifies potential biomarkers. The analysis of metabolic pathways suggests that changes or imbalances in polyamine metabolism and energy metabolism may be primary altered pathways associated with depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Mesud Sarmanlu, Kim P. C. Kuypers, Patrick Vizeli, Timo L. Kvamme
Summary: The use of MDMA in conjunction with psychotherapy for posttraumatic stress disorder (PTSD) has gained renewed interest in recent years. Although clinical trials have shown promising results, the mechanism underlying this treatment is still unclear. This article explores the potential influence of MDMA's mnemonic effects on the efficacy of the treatment, based on recent preclinical and clinical evidence. The findings are corroborated by research from cognitive psychology and psychopharmacology, and recommendations for future research are provided.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Shuyi Deng, Anqi Guo, Zhengwei Huang, Kaiyu Guan, Ya Zhu, Cheekai Chan, Jianfang Gui, Cai Song, Xi Li
Summary: This study investigates the mechanism of anxiety-like behavior caused by CRHR2 deficiency. The results show that CRHR2 deficiency leads to dysfunction of the HPA axis, enhanced neuroinflammation, and reductions in n-3 PUFAs and monoamine neurotransmitters.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Jerillyn Kent, Amy Pinkham
Summary: Social cognition refers to the ways individuals perceive, process, and use information about others. Impairments in social cognition are commonly found in schizophrenia spectrum illnesses and have an impact on functional outcomes. This review summarizes the research on brain networks and cerebellar contributions to social cognitive impairments in this population, while highlighting current knowledge gaps and future directions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Fang Wang, Lulin Dai, Yixin Pan, Peng Huang, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study evaluated the feasibility of unilateral anterior capsulotomy combined with subthalamic nucleus deep brain stimulation (STN-DBS) in managing advanced Parkinson's disease patients with psychosis. The results showed significant improvement in psychosis symptoms, motor symptoms, and quality of life after the combined treatment.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Xiangyuan Chu, Xiu Dai, Ping Yuan, Guojia Qi, Xiuquan Shi
Summary: The prevalence of PTSD among parents of critically ill children is high, with a significantly higher prevalence in mothers than fathers. The risk factors for parental PTSD include positive acute stress disorder screening, disease severity, perceived stress, unemployed status, and length of hospital stay.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Guoshuai Luo, Hongyun Ma, Shuo Wang, Cong Yao, Yaxi Li, Daliang Sun, Xiangyang Zhang
Summary: This study found no sex differences in the prevalence of suicide attempts among patients with anxious depression. The severity of anxiety symptoms and abnormalities in thyroid function were associated with an increased risk for suicide attempts in both male and female patients with anxious depression, while the severity of depression symptoms was only associated with suicide attempts in females.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
