Chemistry, Medicinal

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Article Plant Sciences

A systematical strategy for quality markers screening of different methods processing Platycodonis radix based on phytochemical analysis and the impact on Chronic Obstructive Pulmonary Disease

Tingting Bai, Jingying Guo, Yaling Deng, Yuqing Zheng, Jie Shang, Peng Zheng, Minmin Liu, Ming Yang, Jinlian Zhang

Summary: This study evaluated the phytochemical composition and pharmacodynamics of Platycodon grandiflorum (PG) and Baihezhijiegeng (BJ). The results showed that BJ has anti-COPD activity by regulating inflammatory mediators and the EGFR/MUC5AC pathway in rats with COPD.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Traditional Chinese medicine for neonatal hypoxic-ischemic encephalopathy: A Bayesian network meta-analysis

Chao Zhang, Jiajia Guo, Huaiqing Yin, Chongjuan Yin, Yurong Peng

Summary: This study conducted a network meta-analysis to investigate the efficacy of Chinese herbal injections (CHIs) combined with traditional symptomatic treatment (TST) for neonatal hypoxic-ischemic encephalopathy (HIE). The results showed that CHIs combined with TST significantly improved treatment performance compared to TST alone, with SXI + TST showing the most preferable improvement.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

YuPingFeng (YPF) upregulates caveolin-1 (CAV1) to alleviate pulmonary fibrosis through the TGF-β1/Smad2 pathway

Xiao Chen, Min Wei, Guo-Dong Li, Qi-Liang Sun, Jia-Qi Fan, Jun-Yi Li, Chun-Mei Yun, Dao-Ming Liu, Hong Shi, Yi-Qing Qu

Summary: The study aims to investigate the therapeutic effects of YPF on pulmonary fibrosis. It was found that YPF may have significant therapeutic potential for pulmonary fibrosis by targeting various compounds and pathways, possibly attributed to its ability to up-regulate CAV1 expression and inhibit pulmonary fibrosis through modulation of the TGF-beta 1/Smad2 signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Effect and pharmacological mechanism of Salvia miltiorrhiza and its characteristic extracts on diabetic nephropathy

Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao

Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Hypericum roeperianum bark extract suppresses breast cancer proliferation via induction of apoptosis, downregulation of PI3K/Akt/mTOR signaling cascade and reversal of EMT

Michel-Gael F. Guefack, Debojit Talukdar, Rimi Mukherjee, Subhabrata Guha, Debarpan Mitra, Depanwita Saha, Gaurav Das, Francois Damen, Victor Kuete, Nabendu Murmu

Summary: Hypericum roeperianum, a traditional medicinal spice, has been found to possess anticancer properties. It inhibits breast cancer progression by regulating mitochondrial apoptosis and epithelial-mesenchymal transition (EMT). The crude extract induces apoptosis and inhibits cell migration by affecting multiple molecular markers. Additionally, it modulates the PI3K/Akt/mToR signaling pathway to suppress EMT. The in vitro and in vivo experiments support the potential use of Hypericum roeperianum in breast cancer therapy.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice

Qi Xie, Xianrun Hu, Xiang Zhao, Zedong Xiang, Qianping Chen, Zhejun Xie, Hanxue Wang, Yonglin Zhao, Xuemei Cheng, Changhong Wang

Summary: This study confirmed the positive effects of the macromolecular portion (POL) and small molecule portion (EPP) from Codonopsis Radix (CR) on improving scopolamine-induced memory impairment. The mechanisms involved the regulation of cholinergic function, enhanced antioxidant defense, and suppression of inflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Chemopreventive potential of hydroethanolic Murraya koenigii leaves extract against DMBA induced breast carcinogenesis: In-silico and in-vivo study

Shilpa Sadwal, Sanjay Bharati, Zahid Ahmad Dar, Sarvnarinder Kaur

Summary: The hydroethanolic extract of Murraya koenigii leaves (HEMKLE) shows chemopreventive effects against DMBA-induced breast cancer in rats, likely due to the presence of various phytochemicals.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Di-Huang-Yin-Zi regulates P53/SLC7A11 signaling pathway to improve the mechanism of post-stroke depression

Zhou Yang, Yongxia Jiang, Yang Xiao, Lihui Qian, Yongqu Jiang, Yue Hu, Xiaoli Liu

Summary: The study demonstrates that DHYZ extract can alleviate symptoms and enhance functional capability of rats with post-stroke depression (PSD) by suppressing ferroptosis through the P53/SLC7A11/GPX4 pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The anticonvulsant effect of saiga horn on febrile seizures by regulating brain serotonin content and inhibiting neuroinflammation

Jinhu Li, Xiang Yao, Yurou Wu, Chengwei Wang, Jincheng Yang, Chunjie Wu

Summary: The study demonstrated that Saiga antelope horn (SAH) has a significant anticonvulsant effect on the febrile seizure (FS) rat model. The mechanism may be related to the increase in tryptophan content and up-regulation of the expression of the ER-13/TPH2/5HT signaling pathway in the brain of FS rats, resulting in an increase in brain serotonin (5-HT) content and a decrease in IL-113 and TNF-a content in the brain.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Review Plant Sciences

Efficacy and potential mechanisms of the main active ingredients of astragalus mongholicus in animal models of liver fibrosis: A systematic review and meta-analysis

Lijuan Dan, Yanwei Hao, Hongfei Song, Tianyuan Wang, Jia Li, Xiaoyan He, Yue Su

Summary: This systematic review and meta-analysis demonstrated the effective role of the main active ingredients of Astragalus mongholicus in preclinical studies of liver fibrosis. The main active ingredients were found to lower levels of various indicators associated with liver fibrosis through mechanisms such as attenuation of oxidative stress, modulation of inflammatory response, and inhibition of collagen production. However, caution should be taken due to significant heterogeneity and poor study quality.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Isomaculosidine facilitates NLRP3 inflammasome activation by promoting mitochondrial reactive oxygen species production and causes idiosyncratic liver injury

Wei Shi, Tingting Liu, Huijie Yang, Jia Zhao, Ziying Wei, Yujiao Huang, Zhiyong Li, Hui Li, Longxin Liang, Xiaorong Hou, Yuanyuan Chen, Yuan Gao, Zhaofang Bai, Xiaohe Xiao

Summary: DC can induce idiosyncratic HILI through the activation of NLRP3 inflammasome. This study aims to investigate the mechanism of DC-induced idiosyncratic HILI and identify the susceptible component.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Lanhuashen stimulates the positive cross-regulation mediated by the S1P axis to ameliorate the disorder of glucolipid metabolism induced by the high sucrose diet in Drosophila melanogaster

Gengyuan Yu, Mo Sun, Tonghua Zhang, Haoran Xu, Jiaqi Wang, Wanting Ye, Peng Wang, Shiyun Zhang, Chenning Zhang, Yikun Sun

Summary: Herba Wanlenbergiae (Lanhuashen) is a traditional Chinese medicine derived from Wahlenbergia marginata. This study found that extracts of Herba Wanlenbergiae can regulate glucolipid metabolism and improve the disorder seen in type 2 diabetes mellitus. The extracts were shown to activate the PI3K-Akt signaling pathway and inhibit lysosome-mediated apoptosis, leading to improved glucolipid metabolism.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+antagonism and maintaining mitochondrial function

Gang Shen, Zongyuan Zhou, Yanlei Guo, Li Li, Jin Zeng, Jianbo Wang, Junning Zhao

Summary: Muscone ameliorates neuronal damage through cholinergic signaling of muscarinic receptors, reducing mitochondrial dysfunction and oxidative stress. This study provides a promising therapeutic target for the treatment of stroke-induced nerve injury, offering potential benefits for stroke patients.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Yunvjian decoction attenuates lipopolysaccharide-induced periodontitis by suppressing NFκB/NLRP3/IL-1β pathway

Qitao Ye, Bingfeng Lin, Pingcui Xu, Fanxuan Zhang, Nani Wang, Dan Shou

Summary: The study found that Yunvjian decoction (YNJ) has significant therapeutic effects in the treatment of periodontitis. The results showed that YNJ can inhibit bone resorption, promote bone formation, and reduce inflammation in periodontitis rats. Network pharmacology analysis identified the nucleotide binding oligomerization domain-like receptor signaling pathway as the main mechanism of YNJ in treating periodontitis. Additionally, experiments confirmed that YNJ inhibits pyroptosis and suppresses the NF kappa B/NLRP3/IL-1 beta pathway in alveolar bone.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Preliminary study on the material basis and mechanism underlying uric acid reduction by Thlaspi arvense L.

Xiumei Ke, Xuan Yang, Chao Hou, Yunhong Wang, Yifei Zhou, Tongxuan Wu, Rongping Yang

Summary: In the Tibetan region of China, Thlaspi arvense is used for the prevention and treatment of hyperuricemia. This study aimed to investigate the active ingredients of Thlaspi arvense against hyperuricemia and elucidate the underlying mechanisms. The results showed that Thlaspi arvense led to a significant improvement in hyperuricemia rats by lowering serum levels of uric acid and other markers. Network pharmacological analysis revealed 40 active compounds that act on hyperuricemia therapeutic targets, primarily related to uric acid metabolism modulation. mRNA-sequencing and RT-PCR data analysis identified specific targets involved in uric acid metabolism. Organic acids and flavonoids in Thlaspi arvense may be the active components that alleviate hyperuricemia.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Based on spinal central sensitization creating analgesic screening approach to excavate anti-neuropathic pain ingredients of Corydalis yanhusuo WT Wang

Meng-Yuan Zhou, Chang-Heng Yao, Yu-Jie Yang, Xue Li, Jin Yang, Ji-Hua Liu, Bo-Yang Yu, Wen-Ling Dai

Summary: This study aims to identify active compounds in Corydalis Rhizome (RC) that regulate spinal central sensitization and inhibit neuropathic pain. Through in vitro experiments and animal studies, it was found that glaucine in RC has significant analgesic effects specifically on neuropathic pain.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Study on quality difference between Belamcanda chinensis (L.) DC and Iris tectorum Maxim. based on chemical chromatogram analysis, biological activity evaluation and in vivo distribution rule

Hao Xiong, Yuanfeng Yang, Wenhui Guo, Jinbin Yuan, Wuliang Yang, Meng Gao

Summary: There are significant differences in the multidimensional aspects of appearance, chemical composition, biological activity, pharmacokinetics, and tissue distribution between Belamcanda chinensis (BC) and Iris tectorum Maxim. (ITM). BC and ITM have similar chemical composition, but ITM has higher contents of isoflavones compared to BC. ITM exhibits stronger anti-inflammatory activity and AChE inhibition ability than BC. BC and ITM also differ in their effects on isolated small intestinal smooth muscle in mice. There are also significant differences in drug-time profiles, kinetic parameters, and tissue distribution between the two herbs.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Effect of woohwangchungsimwon and donepezil co-treatment on cognitive function and serum metabolic profiles in a scopolamine-induced model of Alzheimer's disease

Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi

Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Mulberry leaf multi-components exert hypoglycemic effects through regulation of the PI-3K/Akt insulin signaling pathway in type 2 diabetic rats

Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang

Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Bushen Tianjing Recipe inhibits human ovarian granulosa cell line KGN apoptosis induced by miR-23a through the regulation of the sirtuin family

Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu

Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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