Article
Chemistry, Analytical
Xuyang Zhao, Yuxiang Li, Qi Wang, Man Luo, Yi Zhou, Zhihe Guo, Xiang Wu
Summary: A label-free optical detection method with ultrahigh sensitivity and tunable range was developed to monitor protein conformation changes. The biosensor prototype, constructed with overlapping capillaries, successfully monitored the structural variations of silk proteins. This ultrasensitive biosensor has significant potential for clinical diagnosis, healthcare, pharmaceutical screening, and food security.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Chemistry, Analytical
Tae Hoon Eom, Sang Eun Lee, Yeong Jae Kim, Sungkyun Choi, Gi Baek Nam, Jung-El Ryu, Tae Hyung Lee, Jin Wook Yang, Sung Hwan Cho, Seung Ju Kim, Sang Eon Jun, Seonyong Lee, Seungsoo Kim, Hee Jung Park, Ho Won Jang
Summary: Chemoresistive humidity sensors based on ultrathin V2O5•nH2O nanobelts show promising performance in real-time breath monitoring, with rapid response and recovery, as well as excellent selectivity to humidity.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Panwang Hu, Jinjin Liu, Changkun Xia, Bangxiang Liu, Hengjia Zhu, Xiangheng Niu
Summary: Given the significant threats of heavy metals to ecological systems and human health, monitoring them is crucial. This study designs a non-redox nanozyme for detecting Hg2+ without interference from redox substances. The approach demonstrates highly sensitive and specific measurement of Hg2+ with excellent reliability and practicability. It is the first study to detect Hg2+ using phosphatase-mimicking nanozymes, inspiring exploration of new analytical methods with non-redox nanozymes.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Chemistry, Analytical
Chun-Lin Lv, Chang Tang, Hongyan Zhou, Ai-Jun Wang, Jiu-Ju Feng, Tuck Yun Cheang
Summary: In this study, self-supported PtPdMnCoFe high-entropy alloy with nanochain-like internetworks was synthesized and found to be effective in reducing H2O2. It was used as a signal amplifier for the development of a novel label-free electrochemical amperometric immunosensor for ultrasensitive determination of biomarker NSE. The sensor showed a broad linear range and low detection limit for NSE immunoassay, and demonstrated satisfactory results in quantifying NSE in human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Xiaoyan Lang, Xiaxia Xing, Xinhua Zhao, Lingling Du, Yingying Tian, Zhenxu Li, Xiaoyu Chen, Heliang Fan, Dachi Yang
Summary: This study developed NixCu3_x(HHTP)2/PPy nanocomposites for highly selective and stable H2S sensing at room temperature. The NixCu3_x(HHTP)2/PPy NCPs exhibited excellent selectivity to H2S and maintained a 77.3% response for 70 days at room temperature (- 25 degrees C). The sensor prototypes were able to detect H2S as low as 500 ppb and showed stability against humidity.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anran Gao, Fuwen Wang, Zishuo Fan, Shixing Chen, Kejin Wu
Summary: miRNAs have emerged as promising biomarkers in cancer research, but their detection remains challenging. In this study, a photo response calibration method was proposed to enhance the correlation between a silicon nanowire biosensor and q-PCR for the identification of breast cancer miRNA. The use of an uncharged peptide nucleic acid (PNA) for device modification improved the sensor's sensitivity in detecting low concentration miRNA. The improved biosensor demonstrated favorable selectivity and the ability to detect miRNA directly in authentic clinical samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Zhirui Li, Hui Huang, Danna Zhao, Shunji Chen, Weicheng Cai, Tianlin Tang
Summary: A reliable and high-performance oxygen sensor based on TiO2-decorated GaN nanowires was fabricated, which can operate under UV irradiation at room temperature. Experimental results showed that the sensor had maximum response and a limit of detection as low as 0.45% O2 when the TiO2 film thickness was 5 nm. In addition, the sensor exhibited enhanced O2 sensing with lower wavelength UV illumination. The sensor also demonstrated excellent repeatability, selectivity and long-term stability, making it suitable for various applications in the field of O2 gas sensing.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Pengying Liang, Mengxu Sun, Mengyu Chen, Tong Li, Ting Huang, Qingying Zhou, Chunrong Li, Baoping Xie, Jinxiang Chen, Zong Dai, Yuanxin Tian, Jun Chen
Summary: A novel feedback catalytic hairpin assembly (FCHA) was proposed for mRNA imaging in living cells, which demonstrated improved reaction kinetics and sensitivity compared to traditional CHA, and could be used for real-time imaging and indication of changes in mRNA expression.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ruili Wang, Lan Xu, Jishan Li
Summary: A novel visualized chemiluminescence sensor array was developed, which combines the cascade amplification of CHA and HCR with the catalytic activity of G-quadruplex DNAzyme, for simultaneous detection of four cancer-associated miRNAs.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Madhuka V. Liyanage, Robert A. Latour, George Chumanov
Summary: Nanocomposite films containing silver nanoparticles separated by thin polymer layers were fabricated using different methods. The films exhibited changes in electrical conductivity when exposed to moist ammonia and water vapors. The conductivity changes were attributed to hydrogen bonding and direct adsorption. Drop casting method on nylon filter membranes resulted in the most reproducible films. The films with polyvinylpyrrolidone polymer layers showed a low limit of detection for ammonia in the presence of interfering water vapor. The films could be developed as ammonia sensors for environmental and biomedical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Pengqi Gong, Xuegang Li, Qiming Zhao, Xue Zhou, Yanan Zhang, Yong Zhao
Summary: In this paper, a multiparameter DNA hybridization sensor with temperature and pH detection channels based on a fiber-based triple surface plasmon resonance (Triple-SPR) effect is demonstrated. The innovation of this paper lies in the independent temperature and pH testing channels implemented based on a single fiber optic structure, and the high sensitivity DNA hybridization detection channel. Polydimethylsiloxane and self-assembled materials are used for the real-time detection of temperature and pH. After the modification of probe DNA, the selective detection of complementary DNA is achieved. The advantages of multi-parameter independent detection, high sensitivity, and fast response of the fiber-based Triple-SPR sensing technology are of great significance in future multi-parameter sensing, compensated detection, and real-time bio-monitoring applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Kaiyue Han, Yang Li
Summary: In this study, a self-standing high performance flexible capacitive humidity sensor was developed using a composite of polyimide aerogel and graphene oxide. The sensor demonstrated high sensitivity and stability, and could monitor respiration and finger movement while also detecting water content in liquids.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weidong Qin, Junhua Wang, Zhanqiu Tang, Hongyuan Tian, Zhenglong Wu
Summary: Researchers have discovered a rapid and efficient method for immobilizing DNA on gold nanoclusters (AuNCs) using tris(2carboxyethyl)phosphine (TCEP). They have also successfully fabricated a core-shell-satellite nanocomposite for simultaneous detection of microRNA-21 and microRNA-141.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Zhang, Hong Lei, Jiachong Li, Xiaoyan Wang, Hui Yan
Summary: In this study, we proposed a dual signal enhancement strategy for the highly sensitive detection of microRNAs using a fiber optic localized surface plasmon resonance sensor. The method involved the construction of a multimer structure and catalytic amplification to capture and detect miR-103. The sensor demonstrated high specificity, repeatability, and reproducibility, and was successfully validated with real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Chen Meng, Yunhai Chen, Dianwei Zhang, Huilin Liu, Baoguo Sun
Summary: In this study, a novel COFs(azide)@BAs material was prepared for the adsorption of urea and indirect control of EC in Huangjiu processing. The material exhibited a low detection limit for urea and satisfactory removal efficiency for EC, showing great potential for application in food safety control.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Naveen Kumar Arkoti, Kaushik Pal
Summary: Stable and selective gas sensing is crucial for detecting toxic gases and preventing gas leak accidents. In this study, borophene is identified as a potential material for NO2 gas sensing, while a polyetherimide-zeolitic imidazole framework mixed matrix membrane is used as a selective gas separation membrane. Experimental results demonstrate that the fabricated sensors exhibit stable and reliable detection performance for NO2 gas at varying concentrations.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Shuguo Yu, Chu Chen, Peng Li, Hongyan Zhang, Haiyang Zhang
Summary: A highly sensitive and stable Ti3C2Tx MXenes-RGO humidity sensor was developed for real-time respiratory monitoring. The sensor exhibits high sensitivity, low humidity hysteresis, short response/recovery time, and good stability and repeatability.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
