Article
Cell & Tissue Engineering
Katharina Schoenberger, Nadine Obier, Mari Carmen Romero-Mulero, Pierre Cauchy, Julian Mess, Polina Pavlovich, Yu Wei Zhang, Michael Mitterer, Jasmin Rettkowski, Maria-Eleni Lalioti, Karin Jaecklein, Jonathan D. Curtis, Betty Feret, Pia Sommerkamp, Claudia Morganti, Keisuke Ito, Norbert B. Ghyselinck, Eirini Trompouki, Joerg M. Buescher, Erika L. Pearce, Nina Cabezas-Wallscheid
Summary: This study investigates the complex regulatory networks that preserve stemness in hematopoietic stem cells and uncovers a non-classical retinoic acid signaling axis that controls their function. The findings highlight the importance of a single metabolite in controlling stem cell fate through epigenetic and transcriptional attributes.
Article
Cell & Tissue Engineering
Ya-Hui Chan, Kuo-Ning Ho, Yu-Chieh Lee, Meng-Jung Chou, Wei-Zhen Lew, Haw-Ming Huang, Pin-Chuang Lai, Sheng-Wei Feng
Summary: This study found that melatonin can promote the proliferation and osteogenic differentiation of dental pulp-derived MSCs (DPSCs) by regulating COX-2/NF-κB and p38/ERK MAPK signaling pathways. Preconditioning DPSCs with melatonin before transplantation can significantly enhance the function and regenerative capacities of MSCs.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Mohammed E. Grawish, Lamyaa M. Grawish, Hala M. Grawish, Mahmoud M. Grawish, Ahmed A. Holiel, Nessma Sultan, Salwa A. El-Negoly
Summary: Dentin, as a permeable tubular composite, can be demineralized to create a bioactive material called demineralized dentin matrix (DDM). DDM has shown potential in enhancing dental and alveolar bone tissue regeneration. Various forms and shapes of DDM have been studied, and it has been applied in different regenerative procedures, including dentin-pulp complex regeneration and bone and cartilage healing. Further research is needed to establish standardized procedures for specific applications of DDM.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Review
Cell & Tissue Engineering
Faroogh Marofi, Harun Achmad, Dmitry Bokov, Walid Kamal Abdelbasset, Zeid Alsadoon, Supat Chupradit, Wanich Suksatan, Siavash Shariatzadeh, Zahra Hasanpoor, Mahboubeh Yazdanifar, Navid Shomali, Farhad Motavalli Khiavi
Summary: CAR T cell therapy has emerged as a promising treatment option for hematological malignancies, particularly B cell malignancies. However, its effectiveness in solid tumors is hindered by various complications, such as the immunosuppressive tumor microenvironment, tumor antigen heterogeneity, and limited accessibility to tumor cells. Strategies have been recommended to overcome these challenges and enhance the performance of infused T cells.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Maria Luz Alonso-Alonso, Laura Garcia-Posadas, Yolanda Diebold
Summary: Interest in AT-MSC-EVs for therapeutic potential has grown, with numerous proteins and miRNAs identified within, primarily involved in binding function and participating in processes like signal transduction and gene silencing. The therapeutic effects of AT-MSC-EVs are highlighted in biological processes such as inflammation, angiogenesis, and apoptosis.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Nureddin Ashammakhi, Amin GhavamiNejad, Rumeysa Tutar, Annabelle Fricker, Ipsita Roy, Xanthippi Chatzistavrou, Ehsanul Hoque Apu, Kim-Lien Nguyen, Taby Ahsan, Ippokratis Pountos, Edward J. Caterson
Summary: The field of tissue engineering is advancing rapidly, with a focus on addressing the needs of disease states and creating functional products in regenerative medicine. The key to success lies in important ideas and collaborative research efforts between academia and industry.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Cell & Tissue Engineering
Tracy Tran, Cheng Jack Song, Trang Nguyen, Shun-Yang Cheng, Jill A. McMahon, Rui Yang, Qiuyu Guo, Balint Der, Nils O. Lindstrom, Daniel C. -H. Lin, Andrew P. McMahon
Summary: Human pluripotent stem-cell-derived organoids have been modified to generate thousands of similar kidney organoids, which can be used for modeling human kidney development and disease. The models have been used to study polycystic kidney disease and identify compounds that can block cyst formation. Scaling and further development of this platform will greatly enhance its capabilities for kidney disease modeling and high-throughput drug screening.
Article
Cell & Tissue Engineering
Jesus Maria Gomez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng, Yaron Bram, Robert P. Adelson, Tyler M. Lu, Giorgio Inghirami, Jenny Zhaoying Xiang, Raphael Lis, David Redmond, Ryan Schreiner, Sina Y. Rabbany, Dan A. Landau, Robert E. Schwartz, Shahin Rafii
Summary: The heterogeneity of hepatic vascular cells during mouse development was studied through functional and single-cell RNA sequencing. It was found that the acquisition of sinusoidal endothelial cell identity starts during early development and is completed postnatally, with c-Maf playing a critical role in this process.
Article
Cell & Tissue Engineering
Elise C. Jeffery, Terry L. A. Mann, Jade A. Pool, Zhiyu Zhao, Sean J. Morrison
Summary: The contribution of skeletal stem/progenitor cells (SSCs) from bone marrow and periosteum to bone repair has been investigated. During steady-state conditions, new bone primarily arises from bone marrow SSCs. However, after bone injuries, different populations of SSCs play distinct roles in bone repair, with periosteal cells primarily involved in non-stabilized fracture repair.
Article
Cell & Tissue Engineering
Qianju Wu, Longwei Hu, Ran Yan, Junfeng Shi, Hao Gu, Yuwei Deng, Ruixue Jiang, Jin Wen, Xinquan Jiang
Summary: This study aimed to fabricate bioactive scaffolds by incorporating strontium into modified amino-functional mesoporous bioactive glass (MBG) and investigate their bioactivity in vitro and in vivo. The results showed that the strontium-incorporated scaffolds had good biocompatibility and enhanced osteogenic and angiogenic capacities. In addition, bioinformatics analysis suggested that the scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model, playing an anti-osteoporosis role while promoting osteogenesis.
Article
Cell & Tissue Engineering
Jawed Akhtar Siddiqui, Parthasarathy Seshacharyulu, Sakthivel Muniyan, Ramesh Pothuraju, Parvez Khan, Raghupathy Vengoji, Sanjib Chaudhary, Shailendra Kumar Maurya, Subodh Mukund Lele, Maneesh Jain, Kaustubh Datta, Mohd Wasim Nasser, Surinder Kumar Batra
Summary: This study suggests that growth differentiation factor-15 (GDF15) plays a critical role in the modulation of bone microenvironment by prostate cancer (PCa). GDF15 promotes bone metastases and facilitates PCa growth in bone by activating osteoblasts and recruiting osteomacs.
Review
Cell & Tissue Engineering
Elisa Giacomelli, Bjorn F. Vahsen, Elizabeth L. Calder, Yinyan Xu, Jakub Scaber, Elizabeth Gray, Ruxandra Dafinca, Kevin Talbot, Lorenz Studer
Summary: This article evaluates the status of using induced pluripotent stem cells (iPSCs) to model neurodegenerative diseases, focusing on amyotrophic lateral sclerosis (ALS) as an example. It discusses the methods and challenges associated with deriving and using disease-relevant neuronal and glial lineages.
Review
Cell & Tissue Engineering
Chao Li, Hongzhi Lv, Yawei Du, Wenbo Zhu, Weijie Yang, Xiumei Wang, Juan Wang, Wei Chen
Summary: For decades, researchers have focused on the properties and characteristics of implants used in treating large bone defects. Bioabsorbable bone substitute materials have shown promise in reducing inflammation and bone necrosis. However, there are still limitations with current materials, leading to the development of novel composite biomaterials for bone defect repair.
REGENERATIVE THERAPY
(2022)
Review
Cell & Tissue Engineering
Margot Rikkers, Jasmijn Korpershoek, Riccardo Levato, Jos Malda, Lucienne A. Vonk
Summary: This systematic review summarizes the latest research on endogenous progenitor cells in adult articular cartilage. These progenitor cells, called articular cartilage-derived progenitor cells (ACPCs), can be isolated from cartilage of various species including humans, horses, and cows. ACPCs possess mesenchymal stromal cell (MSC)-like characteristics and show no signs of hypertrophic differentiation, making them promising for cartilage repair. However, there is currently no established unique cell marker for identifying ACPCs, leading to variations in isolation and characterization protocols.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Cell & Tissue Engineering
Gaoyang Chen, Canling Long, Shang Wang, Zhenmin Wang, Xin Chen, Wanze Tang, Xiaoqin He, Zhiteng Bao, Baoyu Tan, Jin Zhao, Yongheng Xie, Zhizhong Li, Dazhi Yang, Guozhi Xiao, Songlin Peng
Summary: This study reveals that circStag1 plays a pivotal role in promoting bone tissue regeneration via the HuR/Wnt signaling pathway, which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis.
Article
Cell & Tissue Engineering
Meiping Chu, Hao Wang, Linjie Bian, Jiehui Huang, Danping Wu, Fangli Fei, Ruiting Zhang, Yigang Chen, Jiazeng Xia
Summary: This study demonstrates that nebulization therapy with exosomes of mesenchymal stem cells (MSCs) may be an effective method for treating COVID-19 pneumonia. Nebulization of MSC-derived exosomes does not induce allergic reactions and can promote the absorption of pulmonary lesions, reducing hospitalization duration for mild cases.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Cell & Tissue Engineering
Adrian J. M. Bailey, Heidi Li, Aidan M. Kirkham, Alvin Tieu, Harinad B. Maganti, Risa Shorr, Dean A. Fergusson, Manoj M. Lalu, Heidi Elomazzen, David S. Allan
Summary: Extracellular vesicles from mesenchymal stromal cells (MSC-EVs) show promise in accelerating wound healing particularly in diabetic wounds. Studies have shown that MSC-EVs, especially when enriched in specific RNAs, can significantly improve wound closure, blood vessel density, scar width, and re-epithelialisation in preclinical models of diabetic wounds.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Hao Zhou, Xun Shen, Chen Yan, Wu Xiong, Zemeng Ma, Zhenggang Tan, Jinwen Wang, Yao Li, Jiuxiang Liu, Ao Duan, Feng Liu
Summary: This study demonstrated that hucMSCs-EVs slowed the progression of OA by reducing inflammation, increasing key protein expression, and promoting chondrocyte proliferation, migration, and inhibiting apoptosis. The mechanism involved the regulation of inflammation factors through targeting specific molecules, providing a novel therapeutic approach for clinical OA treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Kasey Y. C. Lau, Hernan Rubinstein, Carlos W. Gantner, Ron Hadas, Gianluca Amadei, Yonatan Stelzer, Magdalena Zernicka-Goetz
Summary: Scientists have developed an in vitro model using mouse embryonic stem cells (ESCs) that can recapitulate mouse embryogenesis, including the interactions between embryonic and extraembryonic tissues. By comparing the transcriptional programs with natural embryos, the model shows remarkable similarity but also some divergences.
Article
Cell & Tissue Engineering
Adam J. Singer
Summary: Cutaneous wound healing is a complex process that occurs in four stages: hemostasis, inflammation, proliferation, and remodeling. Postnatal wound healing often leads to scar tissue formation, while regenerative healing can restore the wound to an uninjured state with minimal scarring. This review focuses on the pathophysiology of acute burn wounds and discusses reparative and regenerative healing mechanisms, as well as the development of novel approaches and therapeutics using components of regenerative healing.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
