Review
Cell & Tissue Engineering
Hye-Jeong Jang, Kyu-Sik Shim, Jinah Lee, Joo Hyeon Park, Seong-Jun Kang, Young Min Shin, Jung Bok Lee, Wooyeol Baek, Jeong-Kee Yoon
Summary: CDNs, as a mimic of exosomes, offer a cost-effective and highly productive alternative in regenerative medicine. Their non-living biomaterial nature, nano-size, and readiness for use allow them to overcome several limitations of conventional cell therapy methods.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale
Summary: Extracellular vesicles (EVs) possess regenerative properties and are considered as future vaccines. The molecular cargo of EVs is influenced by the signal transduction pathways prevailing in the parent cells.
REGENERATIVE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Guizheng Wei, Ke Lu, Muhammad Umar, Zhenglin Zhu, William W. Lu, John R. Speakman, Yan Chen, Liping Tong, Di Chen
Summary: Although aging has traditionally been considered the most important risk factor for osteoarthritis, recent epidemiological evidence suggests a strong association between metabolic abnormalities and osteoarthritis risk, especially in younger individuals. Abnormalities such as obesity and type II diabetes are closely linked to osteoarthritis and affect both weight-bearing and non-weight-bearing joints, implying that the pathogenesis of osteoarthritis is more complex than mechanical stress caused by overweight.
Review
Cell & Tissue Engineering
Yizuo Song, Hejing Liu, Shuya Pan, Xinli Xiang, Miaomiao Ye, Xueqiong Zhu
Summary: Mesenchymal stromal cells (MSCs) have shown great promise in various fields such as regenerative medicine and cancer therapy. However, their role as important components within the tumor microenvironment poses potential tumorigenic risks, hindering their clinical translation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Yu Zhang, Xuefeng Li, Hong Tian, Miaomiao Xi, Jinsong Zhou, Hai Li
Summary: This study provides an optimized chemical induction method to derive endothelial cells (ECs) from human cardiac fibroblasts (CFs), which not only broadens the sources of patient-specific ECs but also provides a good research model of mesenchymal-endothelial transition. Studying the molecular process and regulatory mechanism of CF-EC transdifferentiation will provide valuable references for the in vivo direct transdifferentiation for clinical therapy and deepen the understanding of endothelial development and dysfunction.
TISSUE ENGINEERING PART A
(2023)
Review
Cell & Tissue Engineering
Wei Zhou, Kun Yan, Qiaoran Xi
Summary: The BMP signaling pathway plays a crucial role in embryonic development, tissue homeostasis, and cancer progression. Understanding its interactions with cancer stem cells and the tumor microenvironment is essential for effective therapies. BMP signaling not only regulates CSCs but also influences cell migration, invasion, and metastasis.
Article
Cell & Tissue Engineering
Deng Pan, Xiao Zhang, Kangxin Jin, Zi-Bing Jin
Summary: We created monoallelic CRX by replacing one allele with tdTomato in human embryonic stem cells (hESCs) and studied the pathogenesis in hESCs-derived retinal organoids. We found that gene haploinsufficiency is the mechanism for the dominant pathogenicity of CRX, and observed the translocation of monoallelic CRX+ cells in early retinal differentiation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Katie Williams, Simote T. Foliaki, Brent Race, Anna Smith, Tina Thomas, Bradley R. Groveman, Cathryn L. Haigh
Summary: This study investigated the impact of cell therapy on sporadic Creutzfeldt-Jakob disease (sCJD) using a human cerebral organoid model. The results showed that while the treatment had minimal effects on prions, it had a beneficial impact on organoid function and restored electrophysiological parameters to normal levels. This suggests that cell therapy may have functional benefits in the treatment of human prion diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Vanessa S. Fear, Catherine A. Forbes, Nicole C. Shaw, Kathryn O. Farley, Jessica L. Mantegna, Jasmin P. Htun, Genevieve Syn, Helena Viola, Henrietta Cserne Szappanos, Livia Hool, Michelle Ward, Gareth Baynam, Timo Lassmann
Summary: This study utilized high efficiency CRISPR gene editing and induced pluripotent stem cells (iPSCs) for genetic variant classification in a patient with CHD. Functional testing showed altered action potentials in GATA4 genetic variant cardiomyocytes consistent with patient cardiac abnormalities, demonstrating the utility of iPSCs and CRISPR gene editing for genetic variant interpretation. The method can be applied to other genetic variants in GATA4 or other genes in cardiac disease, providing a centralized assessment pathway for patient genetic variant interpretation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Benjamin Norton, Analia Quirk, Akihiro J. Matsuoka
Summary: This study introduces a customized microfluidic platform capable of generating three-dimensional human vestibular neuronal spheroids differentiated from human induced pluripotent stem cells (hiPSCs). It provides a valuable model system for studying inner ear development, disease, and potential therapeutic interventions.
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Yuelin Wu, Shengyi Gu, Jonathan M. Cobb, Griffin H. Dunn, Taylor A. Muth, Chloe J. Simchick, Baoguo Li, Wujie Zhang, Xiaolin Hua
Summary: Bone marrow-derived mesenchymal stem cells (BMSCs) have been recognized as candidates for the treatment of serious endometrial injuries. In this study, Pectin-Pluronic (R) F-127 hydrogel scaffolds were fabricated to provide a three-dimensional architecture for BMSCs. E2 was encapsulated into W/O/W microspheres to serve as a long-term reliable source of E2 for endometrial regeneration. The BMSCs/E2 MPs/scaffolds system was proven as a promising therapy for endometrial regeneration. Furthermore, exosomes derived from endometrial stromal cells played a paracrine role in endometrial regeneration stimulated by E2, inducing BMSCs differentiation into endometrial epithelial cells.
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Wen-Qing Ma, Ai-Ping Zhuo, Yuan-Ling Xiao, Meng Gao, Yu-Tao Yang, Li-Chao Tang, Yan-Hong Wu, Dan Tian, Xia-Fei Fu
Summary: This study investigates the therapeutic effects of human bone marrow-derived mesenchymal stem cells (hBMSCs) on autoimmune premature ovarian insufficiency (POI) through in vivo and in vitro experiments, providing experimental evidence for the treatment of autoimmune POI by hBMSCs.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
David M. Smadja, Aurelien Philippe, Eloara V. M. Ferreira, Rudolf K. F. Oliveira, Colm Mccabe, Lan Zhao
Summary: The study examined plasma sCD147 levels in Covid-19 patients and found that it was significantly associated with disease severity and survival. sCD147 may serve as a valuable biomarker for hospitalized patients with Covid-19 infection.
STEM CELL REVIEWS AND REPORTS
(2023)
Correction
Cell & Tissue Engineering
Dominga Iacobazzi, Filippo Rapetto, Ambra Albertario, Megan M. Swim, Huidong Jia, Srinivas Narayan, Katie Skeffington, Tasneem Salih, Vincenza Valeria Alvino, Paolo Madeddu, Mohamed T. Ghorbel, Massimo Caputo
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Jiang Tan, Guoping Qiu, Maoqi Wang, Zhuoyuan Yu, Xinyi Ling, John Ogooluwa Aremu, Chunyu Wang, Hao Liu, Aozhou Zhang, Mei Yang, Fei Gao
Summary: This study successfully prepared decellularized scaffolds for rat bladder using an improved perfusion method, providing a new perspective on bladder reconstruction materials.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Kazutoshi Okamoto, Hitomi Matsunari, Kazuaki Nakano, Kazuhiro Umeyama, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Masahito Watanabe, Jun Ohgane, Michael Stirm, Mayuko Kurome, Nikolai Klymiuk, Masaki Nagaya, Eckhard Wolf, Hiroshi Nagashima
Summary: This study demonstrated that DMD-XKOXWT pigs could serve as a suitable large animal model for understanding the pathogenic mechanism in DMD carriers and developing therapies for female DMD carriers.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Eiichi Sawaragi, Hiroki Yamanaka, Yuanjiaozi Li, Tomo Unzai, Shingo Kawabata, Takashi Nakano, Yasuhiro Katayama, Michiharu Sakamoto, Yasuhiko Tabata, Naoki Morimoto
Summary: Silk elastin sponges exhibited a wound healing-promoting effect, with superior neoepithelialization and angiogenesis compared to collagen sponges in a mouse wound model. Silk elastin and collagen sponges may promote wound healing through different mechanisms, with silk elastin possibly enhancing wound healing by facilitating increased macrophage migration.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Feng Shen, Hao Xiao, Qiang Shi
Summary: This study found that MSCs isolated from fibrotic tissue of atrophic nonunion had lower osteogenic and chondrogenic capacity, paracrine function, and anti-senescence compared to MSCs isolated from bone marrow.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Ichinnorov Chimedtseren, Shoji Yamahara, Yasunori Akiyama, Masaaki Ito, Yoshinori Arai, Anar Erdene Gantugs, Nagato Nastume, Taku Wakita, Takahiro Hiratsuka, Masaki Honda, Jorge Luis Montenegro Raudales
Summary: The study demonstrated the bone-forming potential of mRCP over a 12-week period, indicating that mRCP sufficiently resists resorption to promote bone formation through induction of osteoclast activation in the late stages of the healing period.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Y. Hosono, A. Kuwasawa, E. Toyoda, K. Nihei, S. Sato, M. Watanabe, M. Sato
Summary: This study investigated the presence of autoantibodies in synovial fluid from patients who received adipose-derived stem/stromal cell (ADSC) treatment for osteoarthritis (OA). The study found that some patients developed severe knee arthritis after ADSC treatment, and these patients had antibodies against histone H2B in their synovial fluid. These findings provide new insights into the pathogenesis of ADSC treatment-induced severe arthritis.
REGENERATIVE THERAPY
(2023)
