Article
Cell & Tissue Engineering
Hyerim Kim, Hyeonhee Roh, Sang-Heon Kim, Kangwon Lee, Maesoon Im, Seung Ja Oh
Summary: Retinitis pigmentosa is a disease that leads to vision loss, and there is currently a lack of effective anti-inflammatory treatment. This study reports the development of an inflammation-responsive hydrogel that can reduce inflammation and protect retinal function, potentially delaying the progression of the disease.
NPJ REGENERATIVE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Juliana Redondo, Steven Bailey, Kevin C. Kemp, Neil J. Scolding, Claire M. Rice
Summary: This article reviews the role of the bone marrow microenvironment in immune-mediated inflammatory diseases (IMIDs), with a focus on MSCs. It predicts that further research on the bone marrow microenvironment will provide new insights into pathophysiology and aid in the identification of new drug targets and optimization of cell-based therapy in IMIDs.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Precious Earldom Mulaudzi, Heidi Abrahamse, Anine Crous
Summary: Regenerative medicine utilizes stem cells to restore and repair damaged organs and tissues, and one important technique is the generation of three-dimensional organoids. The use of 3D organoids bridges the gap between in vivo and in vitro research, offering advantages over traditional 2D cell culture. This review provides an overview of the advancements in regenerative medicine using stem cells to generate organoids, explores the techniques and applications of 3D organoids, and discusses the challenges and future directions in this field.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Peng-Peng Kuang, Xiao-Qing Liu, Chan-Gu Li, Bi-Xin He, Ying-Chun Xie, Zi-Cong Wu, Cheng-Lin Li, Xiao-Hui Deng, Qing-Ling Fu
Summary: This study investigated the therapeutic advantages of genetically engineered MSCs overexpressing IL-10 for the treatment of allergic airway inflammation. The findings showed that IL-10-MSCs significantly reduced inflammation and improved symptoms in mouse models of allergic airway inflammation. The study provides solid support for the use of genetically engineered MSCs as a potential novel therapy for allergic airway inflammation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Marija Zekusic, Marina Bujic Mihica, Marija Skoko, Kruno Vukusic, Patrik Risteski, Jelena Martincic, Iva M. Tolic, Kreso Bendelja, Snjezana Ramic, Tamara Dolenec, Ivana Vrgoc Zimic, Dominik Puljic, Ivanka Petric Vickovic, Renata Ivekovic, Ivanka Batarilo, Ursula Prosenc Zmrzljak, Alan Hoffmeister, Tiha Vucemilo
Summary: This study provides detailed characterization of the mitotic process and spindle morphologies of limbal stem cells, showing high fidelity and suggesting their use as a safe and high-quality therapy for eye regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
B. Kuebler, B. Alvarez-Palomo, B. Aran, J. Castano, L. Rodriguez, A. Raya, S. Querol Giner, A. Veiga
Summary: This study established the first clinical-grade iPSC haplobank in Spain, utilizing allogenic HLA-matched donors to generate iPSC lines. The iPSCs were expanded and stored under GMP conditions. These iPSCs will be used for the development of advanced therapy medicinal products.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Lee Chuen Liew, Boon Min Poh, Omer An, Beatrice Xuan Ho, Christina Ying Yan Lim, Jeremy Kah Sheng Pang, Leslie Y. Beh, Henry He Yang, Boon-Seng Soh
Summary: This study successfully identified cell surface markers for the purification of cardiac subtype cardiomyocytes, which provides an important foundation for cardiac disease modeling, drug discovery, and regenerative medicine.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Joan C. Fitzgerald, Georgina Shaw, J. Mary Murphy, Frank Barry
Summary: This study analyzed the impact of five widely used culture media formulations on the biological attributes of human bone marrow-derived MSCs. The results showed significant differences in clonogenicity, proliferation, differentiation propensity, and immunomodulatory capacity in response to the composition of the culture medium. Surface marker expression profiles were also affected by the culture medium.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Nuno G. B. Neto, Meenakshi Suku, David A. Hoey, Michael G. Monaghan
Summary: This study reveals the temporal metabolic profile and shift during the osteogenic differentiation of human mesenchymal stem cells (hMSCs), which can be observed as early as day 3 of cell culture. Extracellular lactate is shown to be an essential metabolite and metabolic fuel for efficient osteogenic differentiation and as a signaling molecule to promote glutaminolysis.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell & Tissue Engineering
Senzhe Xia, Xueqian Qin, Jinglin Wang, Haozhen Ren
Summary: Hepatic osteodystrophy is a metabolically associated bone disease caused by chronic liver disease, characterized by osteoporosis and increased risk of fractures. Current treatment mainly focuses on drug therapy to alleviate bone loss, but the effectiveness and safety are unsatisfactory. Mesenchymal stromal cell therapy is an emerging therapeutic approach.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Xiaoyun Wu, Zhijie Ma, Yuxiao Yang, Yongxu Mu, Daocheng Wu
Summary: In this study, the safety and biodistribution of intraperitoneally transplanted umbilical cord-derived MSCs (UCMSCs) were investigated. It was found that UCMSCs cultured in a serum-free, xeno-free, and chemically defined media (UCMSCs&SXFM-CD) exhibited improved safety profiles compared to UCMSCs cultured in serum-containing media (UCMSCsSCM), with no significant toxicity or tumorigenicity observed.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Willem Buys, Elias T. Zambidis
Summary: Granulocytes and macrophages are important components of the innate immune system, which can eliminate pathogens and tumor cells and regulate adaptive immune responses. Engineered myeloid cells have potential applications, such as delivering biocidal agents or anti-inflammatory signals to inflammatory sites, and enhancing tumor killing.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Cell & Tissue Engineering
Xiao Li, Hengrui Hu, Wanlin Liu, Qiyu Zhang, Yujie Wang, Xingjuan Chen, Yunping Zhu, Zhihong Hu, Manli Wang, Jie Ma, Ling Leng
Summary: This study developed an in vitro model of SARS-CoV-2 infection using hiPSC-derived cardiomyocytes and observed different protein expression patterns at different infection timepoints. The findings highlight the importance of early detection and personalized treatment, and identify several potential drug targets.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Mi Ri Suh, Kyunghoon Min, Kye Hee Cho, Jongwook Kim, Ikhyun Lim, Mijin Park, Eun-Min Noh, Min Young Kim
Summary: This study aims to explore the persistent synergistic effects of allogeneic umbilical cord blood (UCB) cells and erythropoietin (EPO) in treating children with cerebral palsy (CP). The results indicate that, compared to baseline scores, all groups showed improvements in outcome measures after 12 months of additional UCB infusion, except for GMFM and GMPM in Group C, which were elevated at 3 and 6 months post-therapy. However, there were no significant differences in outcome measures between the four groups at 3, 6, and 12 months after therapy. Severe dysfunction patients in Group A showed greater improvement in GMPM scores compared to Group D (Ps < 0.05) from the baseline value of the previous trial.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
J. F. Velez-Pinto, M. Garcia-Arranz, D. Garcia-Bernal, S. Garcia Gomez-Heras, P. Villarejo-Campos, A. M. Garcia-Hernandez, L. Vega-Clemente, S. Jimenez-Galanes, H. Guadalajara, J. M. Moraleda, D. Garcia-Olmo
Summary: This study investigates the potential of adipose-derived mesenchymal stem cells (ADSCs) as a therapy for sepsis in a porcine model. The results demonstrate that intraperitoneal administration of ADSCs improves clinical condition, regulates the immune system, and reduces organ damage in abdominal sepsis.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Minseong Kim, Myunggu Yeo, Kyoungho Lee, Min-Jeong Park, Gyeongyeop Han, Chansong Lee, Jihyo Park, Bongsu Jung
Summary: This study aims to establish a simple and novel method to extract and characterize collagen from human adipose tissue. The results showed that the collagen extracted from human adipose tissue is equivalent in quality to commercially available porcine collagen, and it exhibits high cell attachment and promotes cell proliferation.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Philip Greulich
Summary: This article gives an overview of quantitative modelling approaches in biology and provides guidance on how to use them in stem cell research. It points out that while quantitative modelling can boost biological research, careful considerations need to be taken to avoid pitfalls and understand its limitations.
CURRENT STEM CELL REPORTS
(2023)
Review
Cell & Tissue Engineering
Ni Zeng, Wei Tang, Yanghong Wu, Hang Fan, Shuanglun Xie, Nan Cao
Summary: Cardiac fibrosis is a pathological response characterized by excessive deposition of fibrous connective tissue within the heart. Stem cell and lineage reprogramming technologies offer new opportunities for studying and treating cardiac fibrosis. Reprogramming cardiac fibroblasts into cardiomyocyte-like cells is a promising approach for reducing scar volume and promoting myocardial tissue regeneration.
Review
Cell & Tissue Engineering
Roberto Gramignoli, Nicola Hofmann, Marta Agudo-Barriuso, Mariastefania Antica, Ana Flores, Lenart Girandon, Halima Kerdjoudj, Ruta Navakauskiene, Jessica Schiavi, Hanne Scholz, Volodymyr Shablii, Xavier Lafarge, Francisco J. Nicolas, Florelle Gindraux
Summary: Perinatal derivatives have shown potential as adjunct therapeutic strategies and innovative treatments. However, to gain recognition and widespread use in medical practice, rigid manufacturing strategies and compliance with regulatory guidelines are necessary.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Daniel T. Laskowitz, Jesse Troy, Emily Poehlein, Ellen R. Bennett, Elizabeth J. Shpall, John R. Wingard, Brian Freed, Samir R. Belagaje, Anna Khanna, William Jones, John J. Volpi, Eric Marrotte, Joanne Kurtzberg
Summary: This study aimed to determine whether intravenous infusion of stored, unrelated donor umbilical cord blood (UCB) improved functional outcome after stroke. However, the trial was terminated early due to slow accrual and logistical concerns associated with the COVID-19 pandemic, and no clinical benefit was observed between the two groups.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
