Article
Cell & Tissue Engineering
Jinghui Xu, Zhenxiao Ren, Tianzuo Niu, Siyuan Li
Summary: This study discovers that MSCs-EVs attenuate inflammation and oxidative stress in spinal cord injury (SCI) by delivering miR-26b-5p to target the KDM6A/NOX4 axis, facilitating recovery.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Yasuhiro Homma, Sayuri Uchino, Masashi Nagao, Takanori Wakayama, Shin Fukusato, Tomonori Baba, Taiji Watari, Koju Hayashi, Yoshitomo Saita, Muneaki Ishijima
Summary: This study investigates the safety and feasibility of locoregional PRP injection for iliopsoas impingement after THA, and finds that it is both safe and feasible.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Shant Nepal, Jinyan Si, Shohei Ishikawa, Masaki Nishikawa, Yasuyuki Sakai, Aya M. Akimoto, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Takamasa Sakai, Hironori Hojo
Summary: In this study, we evaluated the potential of oligo-tetra-PEG gel (Oligo gel) as a growth factor-releasing scaffold. Compared to tetra-PEG hydrogel (Tetra gel), Oligo gel underwent a higher degree of gel-gel phase separation, demonstrating better protein release and osteogenic potential, and achieving superior regeneration in a mouse calvarial defect model. Therefore, Oligo gel is considered a promising therapeutic biomaterial.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Taichi Tenkumo, Benedikt Kruse, Kathrin Kostka, Viktoriya Sokolova, Toru Ogawa, Nobuhiro Yoda, Oleg Prymak, Osamu Suzuki, Keiichi Sasaki, Matthias Epple
Summary: This study evaluated the bone-healing effects of a triple-functionalized CaP paste in the rat femoral head. The results showed that the paste significantly accelerated bone healing after 21 days and increased the levels of bone formation-related markers at the protein and gene levels.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Yasuyuki Hayashi, Hiroe Ohnishi, Masayuki Kitano, Yo Kishimoto, Toshiaki Takezawa, Hideaki Okuyama, Masayoshi Yoshimatsu, Fumihiko Kuwata, Takeshi Tada, Keisuke Mizuno, Koichi Omori
Summary: This study aimed to establish a trachea-humanized rat model in which human airway epithelial cells can be analyzed, and compared the engraftment efficiency in nude rats and X-SCID rats following hiPSC-AE transplantation. The results showed that X-SCID rats had better engraftment efficiency, providing important guidance for the establishment of trachea-humanized rat models.
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Guopan Liu, Ying Wang, Yilin Pan, Li Tian, Ming Ho Choi, Li Wang, Jin Young Kim, Jian Zhang, Shuk Han Cheng, Liang Zhang
Summary: Hypertonicity induces dedifferentiation of adipocytes through the release of mitochondrial EVs and activation of TNF-α and Wnt/β-catenin signaling pathways.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Andrew I. Morrison, Aleksandra M. Mikula, Sander W. Spiekstra, Michael de Kok, Alsya J. Affandi, Henk P. Roest, Luc J. W. van der Laan, Charlotte M. de Winde, Jasper J. Koning, Susan Gibbs, Reina E. Mebius
Summary: This study established a three-dimensional model simulating human lymph nodes and investigated the influence and importance of fibroblastic reticular cells (FRCs) on dendritic cell (DC) functioning. The results showed that FRCs were crucial for the survival and localization of DCs, and CD1a expression was absent on DCs developed in the presence of FRCs, resembling DCs in natural lymph nodes. FRCs expressed certain markers resembling the DC supporting stromal cell subset in lymph nodes.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid
Summary: This review explores the complex relationship between ARDS and T2DM, highlighting the therapeutic potential and immunomodulatory effects of hUC-MSCs in treating these diseases.
REGENERATIVE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Melis Asal, Mila Rep, Hetty J. Bontkes, Sandra J. van Vliet, Reina E. Mebius, Susan Gibbs
Summary: This article provides an extensive overview of the different types of lamina propria stromal cells found in the small intestine and describes a combination of molecular markers that can be used to distinguish each different stromal cell type. We focus on studies that incorporated stromal cells into human representative small intestine models. These models display enhanced epithelial morphology, increased cell proliferation, and human-like barrier properties.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Cell & Tissue Engineering
O. Krasnova, A. Kovaleva, A. Saveleva, K. Kulakova, O. Bystrova, M. Martynova, A. Domnina, J. Sopova, I. Neganova
Summary: This study investigated the changes occurring within 3D-cultured MSCs and found that 3D-MSCs were able to lose replicative senescence markers, undergo changes in cytoskeleton structure and Golgi apparatus architecture, and exhibit nuclear localization of mTOR. The study also demonstrated that 3D cell culture promotes the phenotypic reversion of senescent cells rather than their removal from the population.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Xilong Bai, Tingwei Chen, Yuqi Li, Xiaofan Ge, Caie Qiu, Huili Gou, Sili Wei, Tingting Liu, Wei Yang, Liting Yang, Yingmin Liang, Zhansheng Jia, Liangshan Lv, Tianqing Li
Summary: This study analyzed the gene expression profiles of Wharton's jelly derived MSCs (WJ-MSCs) from 58 human donors and identified six gene expression profile clusters and four distinct WJ-MSCs subpopulations. The results showed that the immunosuppression capacities of WJ-MSCs were positively correlated with PD-L1 expression, and WJ-MSCs with high expression of PD-L1 were more effective in treating autoimmune hepatitis than those with low PD-L1 expression.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Maryam Alowaysi, Robert Lehmann, Mohammad Al-Shehri, Moayad Baadhaim, Hajar Alzahrani, Doaa Aboalola, Asima Zia, Dalal Malibari, Mustafa Daghestani, Khaled Alghamdi, Ali Haneef, Dunia Jawdat, Fahad Hakami, David Gomez-Cabrero, Jesper Tegner, Khaled Alsayegh
Summary: The study focused on establishing a HLA-based iPSC banking system for the Saudi population to overcome the limitations of autologous iPSC-based cellular therapies. By generating HLA-matched iPSC lines, the study demonstrated pluripotency and differentiation potential, covering a portion of the Saudi population. This approach provides a promising step toward expanding stem cell therapies and regenerative medicine in Saudi Arabia.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell & Tissue Engineering
Han Yang, Sousan Cheong, Yunfan He, Feng Lu
Summary: The application of MSCs presents a promising approach for treating autoimmune-related fibrotic skin diseases: SSc and Scl-GVHD. Therapies involving MSCs and MSC extracellular vesicles have been found to operate through three primary mechanisms: rebalancing the immune and inflammatory disorders, resisting oxidant stress, and inhibiting overactivated fibrosis (including fibroblast activation and ECM remodeling). However, the effectiveness of these interventions requires further validation through extensive clinical investigations, particularly randomized control trials and phase III/IV clinical trials. Additionally, the hypothetical mechanism underlying these therapies could be elucidated through further research.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Lide Su, Guofu Zhang, Lili Jiang, Chao Chi, Bing Bai, Kai Kang
Summary: By knocking out the c-Jun gene in mouse embryonic stem cells using CRISPR-Cas9, it was found that the resulting cells were directed towards a meso-endodermal fate, leading to the generation of beating myocardial cells. This suggests that c-Jun plays a significant role in regulating early cardiac cell development.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Aeri Shin, Jae Ryun Ryu, Byung Gon Kim, Woong Sun
Summary: Fetal spinal cord ischemia is a serious condition with limited understanding and treatment options. We established a screening system using spinal cord organoids and discovered the mild neuroprotective effects of rapamycin.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Soo Jin Park, Yoon Young Kim, Wonhyoung Park, Sunwoo Park, Ji Yeon Han, Sung Woo Kim, Hoon Kim, Seung-Yup Ku
Summary: This study investigated the protective or regenerative effect of cetrorelix on female reproductive organs prior to Anti-PD-L1 therapy using a murine model. The results showed that Anti-PD-L1 treatment led to a decrease in primordial/primary ovarian follicles and impaired decidualization in the uterus, while pretreatment with cetrorelix restored normal decidualization patterns in the uterus but did not significantly improve ovarian follicular reductions.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Cell & Tissue Engineering
Bhavani Gopalakrishnan, Uri Galili, August Dunbar, Luis Solorio, Riyi Shi, Jianming Li
Summary: Resting human microglia treated with alpha-gal nanoparticles and anti-Gal can be activated and polarized towards a pro-healing state, suggesting therapeutic relevance to the CNS microenvironment for tissue repair after spinal cord injury.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Cell & Tissue Engineering
Rabia Onbas, Ahu Arslan Yildiz
Summary: Patterning cells using magnetic manipulation is a rapid and cost-effective method to create three-dimensional cell culture models. This study introduces a new approach using a bioink to pattern cells and successfully fabricates 3D cardiac structures. The developed model shows higher resistance to drug exposure compared to conventional two-dimensional cell culture.
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Tian Tu, Yuan Shi, Boya Zhou, Xiaoyu Wang, Wenjie Zhang, Guangdong Zhou, Xiumei Mo, Wenbo Wang, Jinglei Wu, Wei Liu
Summary: This study identifies collagen I and fibromodulin as key molecules for directing the tenogenic differentiation of human adipose-derived stem cells (hASCs). These molecules show promising results for tendon engineering both in vitro and in vivo.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Cell & Tissue Engineering
Junqin Li, Bin Liu, Hao Wu, Shuaishuai Zhang, Zhuowen Liang, Shuo Guo, Huijie Jiang, Yue Song, Xing Lei, Yi Gao, Pengzhen Cheng, Donglin Li, Jimeng Wang, Yang Liu, Di Wang, Nazhi Zhan, Jing Xu, Lin Wang, Guozhi Xiao, Liu Yang, Guoxian Pei
Summary: Recent studies have shown that sensory nerves not only have afferent functions, but also exert efferent effects to directly alter organ physiology. There is also evidence suggesting the crucial role of sensory nerves in the regulation of osteoclasts. However, the direct efferent influence of sensory nerves on osteoclasts is still lacking. In this study, we found that sensory nerves directly transported high levels of efferent signals into osteoclasts. Furthermore, sensory hypersensitivity significantly increased osteoclastic bone resorption and promoted osteoclastogenesis.
