Cell Biology

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Article Biochemistry & Molecular Biology

Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development

Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang

Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Cell Biology

17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/ Smad axis

Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou

Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)

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Article Cell Biology

Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats

Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin

Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)

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Article Cell Biology

Activation of mitophagy improves cognitive dysfunction in diabetic mice with recurrent non-severe hypoglycemia

Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu

Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)

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Article Cell Biology

Low growth hormone secretion associated with post-acute sequelae SARS-CoV-2 infection (PASC) neurologic symptoms: A case-control pilot study

Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban

Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)

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Article Cell Biology

Transcriptional landscape of human trophoblast cells treated with calcitriol and TGF-131

Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera

Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)

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Article Cell Biology

Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia

Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen

Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2024)

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Article Biochemistry & Molecular Biology

Exploring the power of nitric oxide and nanotechnology for prolonging postharvest shelf-life and enhancing fruit quality

Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron

Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2024)

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Article Biochemistry & Molecular Biology

Tumor protein D52 (isoform 3) induces NF-κB-STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells

K. K. Sruthi, Sirisha Natani, Ramesh Ummanni

Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinoma

Kieran Foley, David Shorthouse, Eric Rahrmann, Lizhe Zhuang, Ginny Devonshire, Rebecca C. OCCAMS Consortium, Rebecca C. Fitzgerald, Benjamin A. Hall

Summary: Metastasis in oesophageal adenocarcinoma (OAC) is a crucial factor affecting survival. Radiological staging is commonly used to assess metastases, but its accuracy is limited. This study analyzed lymph node metastases and identified new roles of genes SMAD4 and KCNQ3 in metastasis. The findings suggest that both genes could serve as novel biomarkers for metastatic risk and offer potential new targets for drug treatment.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Review Biochemistry & Molecular Biology

Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy

Xianzhe Yu, Xiaoqian Zhai, Juan Wu, Qingbo Feng, Chenggong Hu, Lingling Zhu, Qinghua Zhou

Summary: Gastric cancer is a global health problem, and traditional therapies have limited efficacy. Immunotherapy using checkpoint inhibitors, particularly therapeutic antibodies targeting the PD-1/PD-L1 pathway, has made substantial breakthroughs in the treatment of gastric cancer.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

Structure, function and biogenesis of the fungal proton pump Pma1

Margaret R. Young, Sabine Heit, Maike Bublitz

Summary: This article reviews the current progress in the study of the structure, function, and biogenesis of fungal Pma1 and introduces the recently determined high-resolution structures of Pma1 using cryo-electron microscopy, providing new insights into its stability, regulated activity, and druggability.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Biochemistry & Molecular Biology

Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

Thor C. Moller, Ee Von Moo, Asuka Inoue, Mie F. Pedersen, Hans Brauner-Osborne

Summary: This study utilized a TR-FRET internalization assay, combined with CRISPR engineered knockout cells, to investigate the internalization profiles of different GPCRs. The results showed that all the receptors internalized upon agonist stimulation, but there was no correlation between the receptor class and the G protein coupling and dependence for GPCR internalization. This study provides a platform for studying GPCR internalization applicable to most GPCRs.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Biochemistry & Molecular Biology

Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression

Raibel Suarez, Carolina Villarreal, Yessica Nahuelpan, Claudia Jara, Carlos Oyarzun, Sebastian Alarcon, Montserrat M. Diaz-Encarnacion, Elena Guillen-Gomez, Claudia Quezada, Rody San Martin

Summary: This study highlights the importance of insulin regulation in maintaining normal adenosine levels and kidney function through controlling the activity of equilibrative nucleoside transporter-2 (ENT2). However, in diabetic patients, impaired insulin regulation of ENT2 activity leads to chronically high levels of adenosine, which further contributes to the progression of diabetic kidney disease.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

RNA-dependent RNA polymerase of SARS-CoV-2 regulate host mRNA translation efficiency by hijacking eEF1A factors

Haili Gan, Xiaoguang Zhou, Qiong Lei, Linlin Wu, Jianmin Niu, Qingliang Zheng

Summary: The NSP12 protein of COVID-19 virus interacts with the eEF1A factor to regulate the translation efficiency of host mRNAs, affecting the expression of important genes and providing new insights for evaluating the impact of the virus on the host and studying potential drug targets.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

Upregulation of hypothalamic TRPV4 via S100a4/AMPKα signaling pathway promotes the development of diet-induced obesity

Pengjiao Xi, Wenjuan Zhu, Yan Zhang, Meng Wang, Huimin Liang, Haomin Wang, Derun Tian

Summary: The study reveals the significant role of hypothalamic TRPV4 in obesity. Overexpressed hypothalamic TRPV4 leads to weight gain, fat accumulation, and hepatic steatosis, while reducing central inflammation induced by high-fat diet. This suggests that hypothalamic TRPV4 could serve as a potential target for therapeutic intervention against obesity.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

Docosahexaenoic acid (DHA) inhibits abdominal fat accumulation by promoting adipocyte apoptosis through PPARγ-LC3-BNIP3 pathway-mediated mitophagy

Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji

Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2024)

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Article Cell Biology

METTL3 regulates the proliferation, metastasis and EMT progression of bladder cancer through P3H4

Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao

Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.

CELLULAR SIGNALLING (2024)

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Article Cell Biology

Expression and electrophysiological characteristics of VGSC during mouse myoblasts differentiation

Kaizhi Ding, Yanchun Gong, Chunfang Cheng, Xiaonuo Li, Yuanjie Zhu, Xiaofei Gao, Yuhua Li, Chunhua Yuan, Zhibing Liu, Wei Jiang, Chong Chen, Li-Hua Yao

Summary: This study investigates the role of voltage-gated sodium channels (VGSC) in muscle regeneration. The findings suggest that with the progression of differentiation, VGSC expression and intracellular sodium concentration increase, and VGSC dynamics change, potentially contributing to muscle contraction.

CELLULAR SIGNALLING (2024)

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Article Biochemistry & Molecular Biology

Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/ 2-dependent genes to promote the occurrence of atrophic nonunion

Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan

Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.

CYTOKINE (2024)

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