Article
Biochemistry & Molecular Biology
Hebah Fatafta, Batuhan Kav, Bastian F. Bundschuh, Jennifer Loschwitz, Birgit Strodel
Summary: There is increasing evidence linking Alzheimer's disease progression and severity to neuronal membrane damage caused by aggregates of the amyloid-β (Aβ) peptide. The lipid-chaperone hypothesis suggests that complexes between Aβ and free lipids allow for easy insertion into membranes. However, experiments show that 1:1 complexes do not insert into membranes but rather adsorb to the membrane surface, with significant structural changes occurring when Aβ forms a complex with a cluster of lipid molecules.
BIOPHYSICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Min Li, Zhimin Zhang, Boyi Liu, Li Chen, Menghe Wang
Summary: Research has shown that GAS5 can upregulate the expression of miR-214 through methylation pathway, thereby inhibiting cardiomyocyte apoptosis in sepsis.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biophysics
Bruno Gil Rosa, Oluwatomi E. Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A. Crone, Loren P. Cameron, Paul Freemont, Kwang-Leong Choy, Firat Guder, Eric Yeatman, David J. Sharp, Bing Li
Summary: Accurate and cost-effective multiplexed immunosensors are important for early diagnosis and monitoring of progressive diseases. This review compares different techniques for the development of multiplexed immunosensors and discusses the barriers and potential solutions for translating this strategy into clinical practice.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Ayman Abo Elmaaty, Khaled M. Darwish, Muhammad Khattab, Sameh S. Elhady, Mohammed Salah, Mohammed I. A. Hamed, Ahmed A. Al-Karmalawy, Moustafa M. Saleh
Summary: The global prevalence of COVID-19 has driven the search for new effective drugs, with a focus on traditional Chinese medicinal plant compounds such as Salvianolic acid B (Sal-B) showing promising inhibitory effects against SARS-CoV-2 target proteins.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Cuneyt Turkes, Yeliz Demir, Sukru Beydemir
Summary: This study aims to investigate the interaction between certain calcium channel blockers (CCBs) and the enzyme PON1. The results indicate that these drugs inhibit PON1 enzyme activity, with cinnarizine competitively binding to PON1. Further research, including gene expression and in vivo experiments, is needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biophysics
Danaya Phothisarattana, Phanwipa Wongphan, Khwanchat Promhuad, Juthathip Promsorn, Nathdanai Harnkarnsujarit
Summary: The addition of zinc oxide nanoparticles improves the functional properties and extends the shelf life of biodegradable packaging for food. The morphology and dispersion of the nanocomposite films play a crucial role in their performance. High concentrations of zinc oxide have significant effects on inhibiting microbial growth. Under refrigerated conditions, the nanocomposite films effectively extend the shelf life of food.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Tongjia Kang, Jingming Lu, Tian Yu, Yi Long, Guozhen Liu
Summary: Achieving superhigh sensitivity is the ultimate goal in modern bio-detection. Nucleic acid amplification technologies (NAATs) are revolutionizing the field, offering novel methods for diagnosis with high efficiency and cost-effectiveness. This review discusses the principles, recent advancements, strengths, and challenges of different NAATs, with a focus on rapid and accurate point-of-care diagnosis. The application of these technologies in the context of the COVID-19 pandemic is also explored, emphasizing the significance of NAATs in combating the disease. Furthermore, the potential for enhancing sensitivity and specificity in biodetection through NAATs is discussed, aiming to fully exploit the capabilities of each technique.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Syed Shams ul Hassan, Wei-Dong Zhang, Hui-zi Jin, Syed Hussain Basha, S. V. S. Sasi Priya
Summary: In this study, a systematic in silico investigation was conducted on five guaiane-type sesquiterpene dimers. Xylopidimer C showed the best anti-inflammatory activity, with strong interactions with COX2 protein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biophysics
Rouqiao Zheng, Junru Guo, Xinyi Cai, Lianjie Bin, Chengyu Lu, Amita Singh, Manoj Trivedi, Abhinav Kumar, Jianqiang Liu
Summary: Manganese-based Metal-organic Frameworks (Mn-MOFs) have significant potential in biomedical applications, especially in imaging, anti-tumor therapy, and antimicrobial applications. The low toxicity, oxidative ability, and biocompatibility of Mn-MOFs make them highly desirable in medical field. Manganese complexes also show promising prospects in drug targeting.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Jian-Hong Zhu, Hongwei Gou, Tiejun Zhao, Li-Ping Mei, Ai-Jun Wang, Jiu-Ju Feng
Summary: In this study, a novel aptasensor was designed for ultra-sensitive detection of telomerase activity by utilizing Au nanoparticles and Cu2+-modified boron nitride nanosheets as nanozyme. By using Ag2S/Ag nanoparticles decorated ZnIn2S4/C3N4 Z-scheme heterostructures and PEC signal amplification strategy, an aptasensor with a wide linear range and low detection limit was successfully developed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Jiawei Gong, Tongtong Zhang, Tao Luo, Xuan Luo, Fei Yan, Weizhong Tang, Jiyang Liu
Summary: In this study, a novel solid-state electrochemiluminescence (ECL) platform was developed for rapid and ultra-sensitive detection of SARS-CoV-2 antibody. The platform utilizes bipolar silica nanochannel array to stably confine the ECL probe and achieve reliable detection of SARS-CoV-2 IgG.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Valerii Myndrul, Emerson Coy, Nataliya Babayevska, Veronika Zahorodna, Vitalii Balitskyi, Ivan Baginskiy, Oleksiy Gogotsi, Mikhael Bechelany, Maria Teresa Giardi, Igor Iatsunskyi
Summary: In this study, a skin-attachable and stretchable electrochemical enzymatic sensor based on ZnO tetrapods and MXene was developed for continuous glucose detection in sweat. The sensor showed enhanced sensitivity, low limit of detection, and a broad linear detection range, making it suitable for glucose detection in human sweat. The sensor also demonstrated good mechanical stability.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Cong Han, Wenjin Li, Qian Li, Wenping Xing, Hang Luo, Haishuo Ji, Xiaona Fang, Zhaofeng Luo, Liyun Zhang
Summary: In this study, a CRISPR/Cas12a-derived electrochemical aptasensor for fast and ultrasensitive detection of COVID-19 nucleocapsid protein (Np) was developed. The sensor exhibited high selectivity to Np and could complete a test within 30 minutes. It showed great potential in early diagnosis of COVID-19, environmental surveillance, and food security.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Ulviye Acar Cevik, Ismail Celik, Aysen Isik, Iqrar Ahmad, Harun Patel, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: Breast cancer is a common female cancer worldwide. In this study, a series of benzimidazole-1,3,4-oxadiazole derivatives were synthesized and compound 5a exhibited potent anticancer activity against breast cancer cell lines.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Patrick C. F. Buchholz, Golo Feuerriegel, Hongli Zhang, Pablo Perez-Garcia, Lena-Luisa Nover, Jennifer Chow, Wolfgang R. Streit, Juergen Pleiss
Summary: This article summarizes the current known enzymes that act on PET and PUR plastics, and integrates their activity data into a comprehensive database. Through analysis of homologs and conservation, common features of these active enzymes are identified.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Article
Biophysics
Xiaojuan Liu, Hao Cheng, Yuecan Zhao, Yue Wang, Feng Li
Summary: Developing portable, quantitative, and user-friendly analytical tools for sensitive pesticide assay is crucial for ensuring food safety. In this study, a novel electrochemical biosensor was developed for rapid detection of organophosphorus pesticide residues. The biosensor exhibited excellent analytical performance and was useful for evaluating pesticide levels in vegetables.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Louise Finlayson, Isla R. M. Barnard, Lewis McMillan, Sally H. Ibbotson, C. Tom A. Brown, Ewan Eadie, Kenneth Wood
Summary: Research using MCRT to simulate light propagation through skin found that penetration depth of light varies with wavelength and is influenced by the optical properties of skin. The penetration depth of ultraviolet radiation increased when the stratum corneum was thinner. These findings contribute to optimizing light-based diagnostic and therapeutic approaches for skin diseases.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Debanjan Sen, Pradip Debnath, Bimal Debnath, Samhita Bhaumik, Sudhan Debnath
Summary: This study identifies potential inhibitors of the main protease and spike receptor of SARS-CoV-2 from 10 readily available spices. These compounds, found in onion, garlic, ginger, peppermint, chili, and fenugreek, show stability and drug-like properties through molecular docking and dynamic simulation. These findings suggest that these edible spices could be used as home remedies against COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Biochemistry & Molecular Biology
Xueli Tian, Tingxuan Gu, Mee-Hyun Lee, Zigang Dong
Summary: Lung cancer is the most deadly cancer worldwide, with non-small cell lung cancer (NSCLC) being the main type and EGFR as a key driver gene. Despite the effectiveness of EGFR-tyrosine kinase inhibitors in targeted therapy, acquired resistance remains a significant challenge, prompting the exploration of combination treatment options.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
