Article
Biochemistry & Molecular Biology
Cuneyt Turkes, Suleyman Akocak, Mesut Isik, Nebih Lolak, Parham Taslimi, Mustafa Durgun, Ilhami Gulcin, Yakup Budak, Sukru Beydemir
Summary: A series of novel ureido-substituted derivatives with sulfamethazine backbone were investigated for the inhibition of AChE, BChE, and alpha-GLY. Among these derivatives, compound 2c showed the most potent inhibition profile towards AChE and BChE. The study suggests the potential use of inhibitors with sulfamethazine backbone as innovative anticholinergic and antidiabetic agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biophysics
Xiaofeng Jin, Guanhua Li, Tailin Xu, Lei Su, Dan Yan, Xueji Zhang
Summary: Continuous glucose monitoring platform with optimized linear range and long-term stability was developed using a biocompatible conjugated polymer. The system included a small design with signal conditioning, programmable electrochemical chip, and wireless connection. Biocompatibility tests and animal experiments confirmed successful in vivo blood glucose monitoring.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biochemistry & Molecular Biology
Fatemeh BourBour, Samaneh Mirzaei Dahka, Maryam Gholamalizadeh, Mohammad Esmail Akbari, Mahdi Shadnoush, Mohammad Haghighi, Hamidreza Taghvaye-Masoumi, Narjes Ashoori, Saied Doaei
Summary: This paper systematically reviews the impact of nutrients on the immune system and their potential role in the prevention, treatment, and management of COVID-19 in adults. The findings suggest that certain nutrients play an active role in enhancing the functioning of the immune system against viral infections, and supplementation with these nutrients may improve the health status of patients with viral infections.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biophysics
Jianwen Zhuang, Zhiying Zhao, Kai Lian, Lijuan Yin, Jiajing Wang, Shuli Man, Guozhen Liu, Long Ma
Summary: In this study, a RPA-Cas12a-mu PAD was designed using CRISPR/Cas12a and SERS technology for highly sensitive bacterial detection. The concentration of S.typhi was determined by the aggregation level of SERS nanoprobes, enabling fast and accurate testing of food samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Mohamed A. Helal, Shaimaa Shouman, Ahmad Abdelwaly, Ahmed O. Elmehrath, Mohamed Essawy, Shireen M. Sayed, Amr H. Saleh, Nagwa El-Badri
Summary: Lymphopenia is a characteristic feature of COVID-19, possibly due to the entry of SARS-CoV-2 into T cells through the CD147 receptor. Research shows that the viral spike protein binds to CD147 via electrostatic interactions, providing insights for potential treatment strategies against the virus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biophysics
Abdelmonaim Azzouz, Lamia Hejji, Ki-Hyun Kim, Deepak Kukkar, Badredine Souhail, Neha Bhardwaj, Richard J. C. Brown, Wei Zhang
Summary: Surface plasmon resonance (SPR) technology is a valuable tool for the detection of cancer biomarkers, offering advantages such as low cost fabrication, sensitivity, label-free detection, and accuracy. Recent research has focused on utilizing SPR biosensing technology for diagnosing various cancer types, evaluating the performance of SPR biosensors in terms of quality assurance criteria. The limitations and future challenges associated with SPR biosensors for cancer biomarker detection are also discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Huiqing Zhang, Rongyan He, Yan Niu, Fei Han, Jing Li, Xiongwen Zhang, Feng Xu
Summary: This paper reviews the recent advances in the development and modification of graphene-based materials for fabricating advanced wearable sensors, summarizing the design guidelines, sensing mechanisms, applications and evolution. The challenges and future prospects in this field are also discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Quynh Anh Phan, Linh B. Truong, David Medina-Cruz, Can Dincer, Ebrahim Mostafavi
Summary: CRISPR-Dx offers broad enhancements compared to traditional nanobiosensors by utilizing the trans-cleavage activity of the CRISPR/Cas systems. However, the current singlestranded DNA/RNA reporters of CRISPR-Dx have poor stability and limited sensitivity. Research is shifting towards using the trans-cleavage activity of CRISPR/Cas effectors on metal nanoparticles to develop novel nanobiosensors with high accuracy, sensitivity, selectivity, and versatility.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Tahir Rasheed, Komal Rizwan
Summary: This paper systematically summarizes recent breakthroughs in MOFs and their derivatives in enhanced electrochemical sensing applications. The overview part provides insights into the future prospects and directions of MOFs and their derivatives, aiming to overcome present limitations.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Xiancheng Liu, Shuang Zhao, Lili Tan, Yu Tan, Yi Wang, Zhiyi Ye, Changjun Hou, Yan Xu, Shan Liu, Guixue Wang
Summary: This review article provides a comprehensive retrospective analysis of the development, research hotspots, and future trends of electrochemiluminescence (ECL) technology in the past 20 years through quantitative analysis and visual review. It also includes a detailed review and analysis of selected highly cited articles. The article particularly emphasizes the development needs of ECL technology in terms of improving sensor performance, developing materials with excellent ECL performance, innovating and cooperating with other devices, and developing high-speed and high-throughput sensors.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Ruohong Yan, Na Lu, Suping Han, Zhanglu Lu, Yang Xiao, Zhihang Zhao, Min Zhang
Summary: The study introduces an electrochemical aptasensor using MoS2 nanostructuring and SiO2 nano-signal amplification for simultaneous detection of PSA and sarcosine in prostate cancer. This approach allows for ultrasensitive detection, differentiation of cancer patients from healthy individuals, and provides a single-step analysis for accurate diagnosis and early detection of cancer in clinical settings.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Gideon A. Gyebi, Adegbenro P. Adegunloye, Ibrahim M. Ibrahim, Oludare M. Ogunyemi, Saheed O. Afolabi, Olalekan B. Ogunro
Summary: In silico studies were conducted to evaluate 97 alkaloids from African medicinal plants for their interactions with SARS-CoV-2 related proteins. Results showed that more than 15 alkaloids exhibited strong interactions with these proteins, suggesting their potential in altering the virus's ability to enter host cells. Further experimental evaluations are proposed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biophysics
Vishal Chaudhary, Virat Khanna, Hafiz Taimoor Ahmed Awan, Kamaljit Singh, Mohammad Khalid, Yogendra Kumar Mishra, Shekhar Bhansali, Chen-Zhong Li, Ajeet Kaushik
Summary: This article introduces the fifth-generation portable intelligent and multifunctional biosensors embedded on a single chip, which are used for current public health emergencies. The article discusses in detail the advancements in MXene fabrication, physicochemical properties, and the application prospects of MXene-based biosensors in the medical field, as well as the sustainability and challenges associated with these technologies.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Brij Mohan, Sandeep Kumar, Hui Xi, Shixuan Ma, Zhiyu Tao, Tiantian Xing, Hengzhi You, Yang Zhang, Peng Ren
Summary: The study focuses on the application of sensors made of porous metal-organic frameworks (MOFs) in cancer biomarker detection, analyzing factors such as fabrication strategies and structural properties that influence sensing performance, and proposes an innovative technique for detecting cancer biomarkers using luminescence and electrochemical sensors.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Ashkan Bahadoran, Nooshin Bahadoran Baghbadorani, Jeffrey Roshan De Lile, Saeid Masudy-Panah, Behzad Sadeghi, Jinghan Li, Seeram Ramakrishna, Qinglei Liu, Baadal Jushi Janani, Ali Fakhri
Summary: This project investigates Ag doped Sn3O4 nanostructure immobilized on hyperbranched polypyrrole. The product is synthesized by hydrothermal synthesis method. The surface and structural characteristics are studied through instrumental analysis. The nanocomposite exhibits excellent photocatalytic activity under visible light.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biophysics
Tian Tian, Zhiqiang Qiu, Yongzhong Jiang, Debin Zhu, Xiaoming Zhou
Summary: This study introduces a highly efficient dual-gene detection technique based on the orthogonal DNA/RNA collateral cleavage mechanism of the Cas12a/Cas13a system. The technique allows simultaneous detection of multiple amplified products and can be implemented on a portable device for accurate infectious disease screening in resource-limited settings.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Vipul Kumar, Jaspreet Kaur Dhanjal, Priyanshu Bhargava, Ashish Kaul, Jia Wang, Huayue Zhang, Sunil C. Kaul, Renu Wadhwa, Durai Sundar
Summary: A study examined the binding potential of natural compounds Withaferin-A, Withanone, and caffeic acid phenethyl ester to the cell surface receptor TMPRSS2 using molecular docking and molecular dynamics simulations. The results showed that Withanone had stronger interactions with TMPRSS2 and was able to induce changes in its allosteric site. Furthermore, Withanone downregulated TMPRSS2 mRNA expression, suggesting its potential dual action in blocking SARS-CoV-2 entry into host cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Rahul Singh, Vijay Kumar Bhardwaj, Jatin Sharma, Pralay Das, Rituraj Purohit
Summary: The study focuses on the overexpression of CDK2 in relation to cancer, aiming to design new inhibitors to suppress cancer cell proliferation. Comparison with standard inhibitors showed Ligand2 as a potential selective inhibitor for CDK2, with low side effects, based on ligand efficiency and binding affinity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biophysics
Mahmoud Amouzadeh Tabrizi, Juan P. Fernandez-Blazquez, Dahiana Mojena Medina, Pablo Acedo
Summary: A novel molecularly imprinted polymer-based electrochemical sensor has been developed for the determination of SARS-CoV-2-RBD. The fabricated sensor showed high selectivity, sensitivity, and stability in detecting SARS-CoV-2-RBD in saliva samples. The sensor exhibited a good response in a concentration range of 2.0 to 40.0 pg mL(-1) with a low detection limit of 0.7 pg mL(-1).
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Raimundo de A. M. Neto, Cleydson B. R. Santos, Shayanne V. C. Henriques, Leticia de O. Machado, Jorddy N. Cruz, Carlos H. T. de P. da Silva, Leonardo B. Federico, Edivaldo H. C. de Oliveira, Michel P. C. de Souza, Patricia N. B. da Silva, Carlton A. Taft, Irlon M. Ferreira, Madson R. F. Gomes
Summary: This study evaluated the antineoplastic activity of synthetic chalcones in glioblastoma models, showing that these compounds can significantly reduce the viability of tumor cells and interact with serine and lysine amino acids, suggesting potential for inhibiting tumor growth. Molecular dynamics studies were also conducted to investigate the binding mechanism of these compounds with tubulin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
