Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Anton Popov, Raminta Vaiciuleviciute, Gailute Kirdaite, Eiva Bernotiene, Almira Ramanaviciene
Summary: This review discusses the application of polypyrrole (Ppy), an electroconductive polymer, in cell culture experiments with electrical stimulation (ES) and its potential for tissue regeneration. Ppy can direct ES to cells and stimulate differentiation towards different cell lineages. Different types of Ppy materials and their combination with active molecules are explored.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Weiwei Zhang, Wenwen Wang, Yueyue Yu
Summary: A multi-amplified electro-chemiluminescence aptasensor was developed for efficient recognition of the tumor marker CA125 in ovarian cancer. The sensor utilizes a tetrahedral DNA nanostructure and gold nanoparticles/Ru(bpy)32+/metal-organic framework signal probe for enhanced detection. The aptasensor shows high sensitivity and reliability, making it suitable for clinical analysis of CA125 detection.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Joelle Saulnier, Catherine Jose, Florence Lagarde
Summary: This review provides an overview of the currently available electrochemical techniques, particularly impedimetric and voltamperometric methods, highlighting their recent advances in antibiotic susceptibility testing and microbial biofilm monitoring.
BIOELECTROCHEMISTRY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Alba Montero-Jodra, Miguel Angel de la Fuente, Dino Gobelli, Marta Martin-Fernandez, Jesus Villar, Eduardo Tamayo, Maria Simarro
Summary: Sepsis is the leading cause of infection-related death worldwide, and there is currently no specific treatment available. This review provides an overview of the important role of endothelial cell activation and dysfunction in sepsis development, as well as the involvement of mitochondria as potential targets in experimental models.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chenyi Zhuo, Dehong Yu, Jiuying Cui, Zichun Song, Qianli Tang, Xianjiu Liao, Zhao Liu, Ning Xin, Lu Lou, Fenglei Gao
Summary: A label-free detection strategy for quantification of Apolipoprotein A4 (Apo-A4) has been developed based on rolling circle amplification (RCA) and proximity hybridization-induced DNAzyme-driven bipedal DNA walker. This method shows high sensitivity and selectivity for a wide range of protein targets.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiaopeng Hou, Qiongyi Cheng, Hui Wang
Summary: A self-cleaning paper-based microfluidic biosensor was developed using hydrophobic paper decorated with polymeric octadecyl trichlorosilane. The biosensor showed improved performance and could effectively measure the concentration of copper ions in livestock feed and manure.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Cong Guan, Wei Li, Guoliang Wang, Ruimei Yang, Jinglei Zhang, Jinhong Zhang, Bo Wu, Run Gao, Chunlin Jia
Summary: This study characterized the expression profiles of mRNAs and ncRNAs in switchgrass under drought stress. The up-regulated mRNAs were enriched in starch and sucrose metabolism pathway, while the differentially expressed lncRNAs potentially regulated protein-coding genes. The study also constructed regulatory networks and validated the functionality of the target gene PvSS4 in enhancing drought tolerance.
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Doha M. Beltagy, Nagat F. Nawar, Tarek M. Mohamed, Ehab Tousson, Mai M. El-Keey
Summary: This study aimed to evaluate the protective role of nanocurcumin as an antioxidant and anti-inflammatory agent, and its synergistic effects with Donepezil in the treatment of Alzheimer's disease in rats. The results showed that treatment with nanocurcumin improved memory, locomotion, and neuronal differentiation by activating the PI3K/AKT/GSK-3 beta pathway.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2024)
Article
Biochemistry & Molecular Biology
David Alejandro Miranda Mercado, Erika Viviana Godoy Alarcon, Ely Dannier V-Nino
Summary: This research work investigates the time evolution of electrical properties of gram-positive and gram-negative bacteria in the presence of methyl violet and Lugol. The results show that the impedance magnitude decreases with an increasing bacterial population for both strains, but the rate of impedance magnitude variation over time is different between gram-positive and gram-negative bacteria. These findings suggest that the time evolution of electrical impedance spectra can be used to differentiate Staphylococcus aureus from Escherichia coli bacteria.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Artavazd Badalyan, Zhi-Yong Yang, Lance C. Seefeldt
Summary: The molybdenum-iron protein (MoFeP) is a component of the enzyme nitrogenase and can catalyze the reduction of various small molecules. However, it has been found that increasing the driving force alone cannot achieve efficient electrochemical activation of MoFeP.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Zan Cebron, Mihajlo Djokic, Miha Petric, Maja Cemazar, Masa Bosnjak, Gregor Sersa, Blaz Trotovsek
Summary: This study presents a novel treatment approach for pancreatic cancer combining surgical resection and intraoperative electrochemotherapy. Preliminary results suggest that this hybrid approach is safe and feasible.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Emadoddin Amin Sadrabadi, Ali Benvidi, Mostafa Azimzadeh, Leila Asgharnejad, Amin Shiralizadeh Dezfuli, Patricia Khashayar
Summary: In this study, a novel microRNA biosensor based on magnetic rod carbon paste electrodes was developed for breast cancer detection using a relatively new MOF structure as a substrate. The biosensor showed a very low detection limit and a wide dynamic range, indicating its potential for clinical diagnostics.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
