Andrology

Article Andrology

Fear about adverse effect on fertility is a major cause of COVID-19 vaccine hesitancy in the United States

Parris Diaz, John Zizzo, Navin C. Balaji, Rohit Reddy, Kajal Khodamoradi, Jesse Ory, Ranjith Ramasamy

Summary: The fear of unknown long-term adverse effects and concerns about the impact on reproductive health and fertility are major reasons for vaccine hesitancy among unvaccinated adults. Providing more information and research on the COVID-19 vaccines is seen as the most effective way to encourage vaccine uptake.

ANDROLOGIA (2022)

Article Andrology

Testicular pathology in fatal COVID-19: A descriptive autopsy study

Amaro N. Duarte-Neto, Thiago A. Teixeira, Elia G. Caldini, Cristina T. Kanamura, Michele S. Gomes-Gouvea, Angela B. G. dos Santos, Renata A. A. Monteiro, Joao R. R. Pinho, Thais Mauad, Luiz F. F. da Silva, Paulo H. N. Saldiva, Marisa Dolhnikoff, Katia R. M. Leite, Jorge Hallak

Summary: Pathological findings in testes from fatal COVID-19 cases showed a combination of orchitis, vascular changes, basal membrane thickening, Leydig and Sertoli cell scarcity, and reduced spermatogenesis associated with local SARS-CoV-2 infection, which may impair hormonal function and fertility in men.

ANDROLOGY (2022)

Article Andrology

The relationship of serum testosterone levels with the clinical course and prognosis of COVID-19 disease in male patients: A prospective study

Ahmet Emre Cinislioglu, Nazan Cinislioglu, Saban Oguz Demirdogen, Emre Sam, Fatih Akkas, Mehmet Sefa Altay, Mustafa Utlu, Irem Akin Sen, Fatih Yildirim, Seyfi Kartal, Hasan Riza Aydin, Ibrahim Karabulut, Isa Ozbey

Summary: The study found that lower serum total testosterone levels in male COVID-19 patients were associated with poor prognosis and fatal outcomes, indicating a potential role for testosterone in the pathogenesis of the disease. This could help clinicians determine the clinical course of COVID-19.

ANDROLOGY (2022)

Review Andrology

Exploring the role of gut microbiome in male reproduction

Yan Wang, Zuogang Xie

Summary: This article reviews the possible mechanisms and therapeutic opportunities related to the impact of the gut microbiome on male reproduction, and emphasizes the need for further research in the future.

ANDROLOGY (2022)

Article Andrology

Testosterone in males with COVID-19: A 7-month cohort study

Andrea Salonia, Marina Pontillo, Paolo Capogrosso, Silvia Gregori, Cristina Carenzi, Anna Maria Ferrara, Isaline Rowe, Luca Boeri, Alessandro Larcher, Giuseppe A. Ramirez, Cristina Tresoldi, Massimo Locatelli, Giulio Cavalli, Lorenzo Dagna, Antonella Castagna, Alberto Zangrillo, Moreno Tresoldi, Giovanni Landoni, Patrizia Rovere-Querini, Fabio Ciceri, Francesco Montorsi

Summary: Although total testosterone levels increased over time after COVID-19, more than 50% of men who recovered from the disease still had circulating testosterone levels suggestive for a condition of hypogonadism at 7-month follow-up. In as many as 10% of cases, testosterone levels even further decreased. Of clinical relevance, the higher the burden of comorbid conditions at presentation, the lower the probability of testosterone levels recovery over time.

ANDROLOGY (2022)

Review Andrology

Rehabilitation Nutrition and Exercise Therapy for

Shingo Kakehi, Hidetaka Wakabayashi, Hayato Inuma, Tomomi Inose, Moeka Shioya, Yohei Aoyama, Taiki Hara, Kosuke Uchimura, Kazusa Tomita, Mizuki Okamoto, Masato Yoshida, Shohei Yokota, Hayato Suzuki

Summary: Sarcopenia is an age-related loss of skeletal muscle that can be prevented and treated through exercise and nutritional management. Excessive bedrest and mismanagement of nutrition in medical facilities can lead to iatrogenic sarcopenia, while nutrition and exercise therapy can improve treatment effectiveness and patient functional recovery.

WORLD JOURNAL OF MENS HEALTH (2022)

Article Andrology

Prospective two-arm study of the testicular function in patients with COVID-19

Dmitry Enikeev, Mark Taratkin, Andrey Morozov, Vladislav Petov, Dmitry Korolev, Anastasia Shpikina, Leonid Spivak, Svetlana Kharlamova, Irina Shchedrina, Oleg Mestnikov, Dmitry Fiev, Timur Ganzha, Marina Geladze, Aichurok Mambetova, Evgenia Kogan, Nikolay Zharkov, Gregory Demyashkin, Shahrokh F. Shariat, Petr Glybochko

Summary: This study aimed to investigate the effects of COVID-19 on the male reproductive system. The results showed that COVID-19 significantly affected male hormone levels and sperm quality during the onset of the disease. However, these effects returned to normal within 3 months.

ANDROLOGY (2022)

Article Andrology

YouTube as a source of information on penile prosthesis

Marco Capece, Angelo Di Giovanni, Lorenzo Cirigliano, Luigi Napolitano, Roberto La Rocca, Massimiliano Creta, Gianluigi Califano, Felice Crocetto, Claudia Colla Ruvolo, Giuseppe Celentano, Alessandro Palmieri

Summary: The study found that the quality of information on YouTube regarding penile prosthesis is generally poor, with most videos failing to provide complete patient information and containing misinformation. The majority of videos (68%) were non-surgical, while 32% included surgical procedures, and most were uploaded by private companies.

ANDROLOGIA (2022)

Article Andrology

Are sperm parameters able to predict the success of assisted reproductive technology? A retrospective analysis of over 22,000 assisted reproductive technology cycles

Maria Teresa Villani, Daria Morini, Giorgia Spaggiari, Angela Immacolata Falbo, Beatrice Melli, Giovanni Battista La Sala, Marilina Romeo, Manuela Simoni, Lorenzo Aguzzoli, Daniele Santi

Summary: The study found that sperm motility and morphology play important roles in predicting fertilization rate, pregnancy rate, and live birth rate in assisted reproductive technology. These parameters can be considered reliable tools to measure the male role in ART outcomes, potentially impacting the clinical management of infertile couples.

ANDROLOGY (2022)

Article Andrology

Minocycline can reduce testicular apoptosis related to varicocele in male rats

Majid Shokoohi, Arash Khaki, Ayda Roudi Rasht Abadi, Linda MohammadZadeh Boukani, Sepideh Hassanpour Khodaie, Hossein Kalarestaghi, Amir Afshin Khaki, Maryam Moghimian, Hamid Reza Niazkar, Hamed Shoorei

Summary: The current study aimed to assess the effects of Minocycline on testicular injury caused by varicocele, focusing on apoptotic-related genes and oxidative stress. The results demonstrated that Minocycline administration improved testicular injury and reduced apoptosis rate, possibly through its antioxidant activity.

ANDROLOGIA (2022)

Article Andrology

Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors

Itai Gat, Alon Kedem, Michal Dviri, Ana Umanski, Matan Levi, Ariel Hourvitz, Micha Baum

Summary: This study investigates the impact of the covid-19 vaccine on semen parameters and finds a temporary decline in sperm concentration and total motile count in the short term, but long-term recovery is expected.

ANDROLOGY (2022)

Review Andrology

Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

Ashok Agarwal, Ala'a Farkouh, Neel Parekh, Armand Zini, Mohamed Arafa, Hussein Kandil, Nick Tadros, Gian Maria Busetto, Rafael Ambar, Sijo Parekattil, Florence Boitrelle, Hassan Sallam, Sunil Jindal, Edmund Ko, Mara Simopoulou, Hyun Jun Park, Mohammad Ali Sadighi, Ramadan Saleh, Jonathan Ramsay, Marlon Martinez, Haitham Elbardisi, Juan Alvarez, Giovanni Colpi, Jaime Gosalvez, Donald Evenson, Rupin Shah

Summary: This article evaluates and compares two clinical practice guidelines on sperm DNA fragmentation, finding similar recommendations and highlighting differences between them. The best practice recommendations from both guidelines are summarized and combined.

WORLD JOURNAL OF MENS HEALTH (2022)

Review Andrology

The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes

Teresa Vezza, Pedro Diaz-Pozo, Francisco Canet, Aranzazu M. de Maranon, Zaida Abad-Jimenez, Celia Garcia-Gargallo, Ildefonso Roldan, Eva Sola, Celia Banuls, Sandra Lopez-Domenech, Milagros Rocha, Victor M. Victor

Summary: This review explores the molecular mechanisms of mitochondrial fusion and fission processes, their role in type 2 diabetes, and the therapeutic potential of targeting mitochondrial dynamics in this complex metabolic disorder.

WORLD JOURNAL OF MENS HEALTH (2022)

Article Andrology

Evaluation of mid- and long-term impact of COVID-19 on male fertility through evaluating semen parameters

Bintao Hu, Kang Liu, Yajun Ruan, Xian Wei, Yue Wu, Huan Feng, Zhiyao Deng, Jihong Liu, Tao Wang

Summary: In the later stages of the pandemic, sperm quality of COVID-19 recovered patients improved, while the total sperm number started to improve after about 150 days. Close monitoring during the recovery period and providing medical interventions if necessary may help enhance fertility in male patients as soon as possible.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2022)

Article Andrology

COVID-19 vaccination is associated with a decreased risk of orchitis and/or epididymitis in men

Chase Carto, Sirpi Nackeeran, Ranjith Ramasamy

Summary: The study found that receiving at least 1 COVID-19 vaccine is associated with a decreased risk of developing orchitis and/or epididymitis after balancing for confounding variables.

ANDROLOGIA (2022)

Article Andrology

Erectile and sexual dysfunction in male and female patients with celiac disease: A cross-sectional observational study

Lorenzo Romano, Raffaele Pellegrino, Carmine Sciorio, Biagio Barone, Antonietta Gerarda Gravina, Antonio Santonastaso, Caterina Mucherino, Silvia Astretto, Luigi Napolitano, Achille Aveta, Savio Domenico Pandolfo, Davide Loizzo, Francesco Del Giudice, Matteo Ferro, Ciro Imbimbo, Marco Romano, Felice Crocetto

Summary: The study found that sexual dysfunction is prevalent in celiac disease patients. Early age at diagnosis and high body mass index appear to be predictors of sexual dysfunction. The assessment of sexual function should be included in the initial evaluation of celiac disease patients for prompt diagnosis and treatment.

ANDROLOGY (2022)

Article Andrology

4BNT162b2 mRNA COVID-19 vaccine and semen: What do we know?

Soraya Olana, Rossella Mazzilli, Gerardo Salerno, Virginia Zamponi, Maria Grazia Tarsitano, Maurizio Simmaco, Donatella Paoli, Antongiulio Faggiano

Summary: This study found no significant differences in spermatozoa parameters before and after mRNA COVID-19 vaccine inoculations, suggesting that the vaccine is safe for male semen quality.

ANDROLOGY (2022)

Review Andrology

Human semen quality as affected by SARS-CoV-2 infection: An up-to-date review

Saleem Ali Banihani

Summary: This study reviewed the impact of SARS-CoV-2 infection on human semen quality and found no evidence of viral shedding in semen at different stages of infection, but a negative impact on sperm count and motility was observed. Long-term comparative studies post-recovery are deemed important in this setting.

ANDROLOGIA (2022)

Review Andrology

The Effect of Metformin on Male Reproductive Function and Prostate: An Updated Review

Chin-Hsiao Tseng

Summary: Metformin has various effects on men's health, with potential impacts on erectile dysfunction, steroidogenesis, spermatogenesis, prostate specific antigen, prostatitis, benign prostate hyperplasia, and prostate cancer. Studies on metformin's effects on these conditions are ongoing, with conflicting results on its effectiveness.

WORLD JOURNAL OF MENS HEALTH (2022)

Article Andrology

The association of free testosterone levels with coronavirus disease 2019

Tugce Apaydin, Saida Dashdamirova, Ceyda Dincer Yazan, Onur Elbasan, Can Ilgin, Huseyin Bilgin, Haydar Kamil Cam, Gunel Bahramzada, Aleyna Kucuk, Goncagul Haklar, Hulya Iliksu Gozu

Summary: Coronavirus disease 2019 can have acute and chronic effects on gonadal functions, leading to decreased testosterone levels. Low testosterone levels are associated with increased inflammatory response and worsened clinical conditions. The study revealed a high prevalence of hypogonadism, with a significant portion of patients still experiencing hypogonadism during long-term follow-up.

ANDROLOGY (2022)