Andrology 类别的文章

Article Andrology

Novel ACTL7A variants in males lead to fertilization failure and male infertility

Meng Wang, Juepu Zhou, Rui Long, Huizi Jin, Limin Gao, Lixia Zhu, Lei Jin

Summary: This study investigates the genetic causes of male-related fertilization failure. Mutations in the ACTL7A gene were found to be responsible for fertilization failure and male infertility.

ANDROLOGY (2023)

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Article Andrology

Value of digital rectal examination in patients with suspected prostate cancer: a prospective cohort analysis study

Yidie Ying, Wei He, Qiao Xiong, Ziwei Wang, Maoyu Wang, Qing Chen, Meimian Hua, Shuxiong Zeng, Chuanliang Xu

Summary: Digital rectal examination (DRE) can be used as an adjunctive method in the detection of prostate cancer (PCa), helping physicians determine the necessity of biopsy and provide preliminary information about tumor location and invasiveness.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

Alterations in testicular positioning after normal descent: acquired cryptorchidism

Carme Grande-Moreillo, Sara Fuentes-Carretero, Jaume Margarit-Mallol, Carlos Perez-Lopez, Alejandro Rodriguez-Molinero

Summary: Acquired cryptorchidism accounts for more than half of cryptorchidism cases requiring surgery in our setting, with a clearly different age of presentation than that for congenital cryptorchidism.

ANDROLOGY (2023)

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Article Andrology

Sleep duration and biomarkers of fecundity in young men: a cross-sectional study from a population-based cohort

Anne Gaml-Sorensen, Maria Kongerslev Frolich, Nis Brix, Andreas Ernst, Jens Peter Ellekilde Bonde, Karin Sorig Hougaard, Sandra Sogaard Tottenborg, Pernille Jul Clemmensen, Gunnar Toft, Cecilia Host Ramlau-Hansen

Summary: This study investigated the association between sleep duration and biomarkers of male fecundity in young men, finding that maintaining a recommended sleep duration may be beneficial for reproductive health in young men.

ANDROLOGY (2023)

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Article Andrology

Is SARS-CoV-2-induced disease a decisive factor influencing testosterone in males? Findings from a case-control ex post facto study

Paolo Capogrosso, Alessandro Bertini, Marina Pontillo, Anna Maria Ferrara, Alice Cotelessa, Cristina Carenzi, Giuseppe A. Ramirez, Cristina Tresoldi, Massimo Locatelli, Antonella Castagna, Francesco De Cobelli, Moreno Tresoldi, Alberto Zangrillo, Giovanni Landoni, Patrizia Rovere-Querini, Fabio Ciceri, Francesco Montorsi, Giacomo Monti, Andrea Salonia

Summary: This study found lower circulating tT levels in male patients with COVID-19 compared to those without COVID-19, despite both groups being admitted to the ICU for severe ARDS.

ANDROLOGY (2023)

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Article Andrology

Retroperitoneoscopic enucleation adrenalectomy: a viable surgical option for small nonsecreting adrenal tumors with low potential of malignancy

Hao Yan, Gan Cao, Xin Cui, Jiang-Tao Wu, Tong-Wen Ou, Qi Wang, Bo Cui, Wei Gao, Chun-Song Jia, Jian-Jun Xu

Summary: This study assessed the clinical outcomes of retroperitoneoscopic adrenal tumor enucleation technique, which was found to be a feasible and safe method for removing adrenal tumors while preserving functional adrenal tissue.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Review Andrology

Novel laser therapies and new technologies in the endoscopic management of upper tract urothelial carcinoma: a narrative review

Amanda A. Myers, Raymond W. Pak

Summary: This article provides an overview of available laser therapies and ureteroscopic technologies for the endoscopic management of UTUC, emphasizing the importance of appropriate patient selection for successful endoscopic management.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

Curcumin Attenuates Ferroptosis and Ameliorates Erectile Function in Diabetic Rats by Activating Nrf2/HO-1 Pathway

Yuehui Jiang, Siyan Xing, Dawei Ni, Baibing Yang, Jun Kai, Tong Wang, Wen Yu, Yutian Dai

Summary: The study found that curcumin can improve diabetic erectile dysfunction (ED) in rats and related tissue and molecular changes. Curcumin alleviates ferroptosis in penile endothelial cells stimulated by high glucose through Nrf2/HO-1 signaling pathway.

ANDROLOGIA (2023)

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Article Andrology

Construction of the prognostic model in non-metastatic renal cancer patients with venous tumor thrombus

Baohua Zhu, Yiren Yang, Huangfu Zhao, Wei Zhang, Aimin Jiang, Linhui Wang

Summary: This study aimed to investigate the efficacy and prognostic factors of surgical treatment in non-metastatic renal cancer patients with venous tumor thrombus (VTT). The results showed that surgical treatment improved the prognosis of patients. Kidney tumor diameter, preoperative lactate dehydrogenase (LDH), and preoperative neutrophils were identified as independent risk factors.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Review Andrology

Host defense amyloids: Biosensors of the immune system?

Caitlyn Myers, Gail A. Cornwall

Summary: There is significant evidence that amyloids, highly ordered aggregate structures, play crucial biological roles in various species, including bacteria and humans. Antimicrobial peptides/proteins often form amyloids to carry out host defense functions, indicating their preservation across different organisms. This review focuses on the epididymal amyloid matrix and discusses the common properties of host defense amyloids, including their unique traits as powerful biosensors of the immune system.

ANDROLOGY (2023)

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Article Andrology

Pharmacological investigation of vitamin E with combined oral contraceptives on INHBA gene against PCOS that intricate through melatonin PKC pathway

Rukaiah Fatma Begum, Sumithra Mohan

Summary: The study aimed to assess the effect of vitamin E in combination with a combined oral contraceptive on continuous light-induced polycystic ovary syndrome (PCOS). The results showed that the combination of vitamin E and the contraceptive modulated hormone levels, reduced oxidative stress, and influenced circadian rhythm through the melatonin PKC pathway, thereby combating PCOS.

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2023)

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Article Andrology

Analysis of prognostic factors in patients diagnosed with bladder cancer complicated by hemorrhage treated by drug-eluting bead embolization

Jianyang Peng, Zhicheng Weng, Chunsheng Zhang, Guohui Zhou, Yuanzhen Lin, Damian Kolat, Juan Chipollini, Weida Wu

Summary: This retrospective study evaluated the effect and prognostic factors of transcatheter drug-eluting bead (DEB) embolization in patients with advanced bladder cancer. The results showed that most patients achieved complete hemostasis within 5 days after the first intervention, and the total effective rate was 64.1%, with a disease benefit rate of 79.5%. Logistic regression analysis indicated that the type of blood supply in bladder cancer may influence the efficacy of the intervention, and hematuria recurrence was significantly associated with the total number of tumors and the type of blood supply.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Review Andrology

Male contraception: narrative review of ongoing research

Eli J. Louwagie, Garrett F. L. Quinn, Kristi L. Pond, Keith A. Hansen

Summary: This article discusses novel strategies and targets for male contraception, with two hormonal methods undergoing phase II clinical trials for safety and efficacy. There are also several non-hormonal methods showing strong potential in preclinical stages of development.

BASIC AND CLINICAL ANDROLOGY (2023)

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Review Andrology

Single instillation intravesical chemotherapy after radical nephroureterectomy for upper tract urothelial carcinoma: current evidence and future directions

Justin Refugia, Matvey Tsivian

Summary: Upper urinary tract urothelial carcinoma (UTUC) is a rare type of urothelial carcinoma, accounting for approximately 5% to 10% of cases. Radical nephroureterectomy (RNU) is currently considered the gold standard treatment for high-grade UTUC. However, despite treatment, bladder recurrence still occurs in 22% to 47% of cases. To decrease bladder recurrences, current guidelines recommend single dose, postoperative intravesical chemotherapy (pIVC) following RNU. Despite level 1 evidence supporting these guidelines, the utilization of pIVC remains low, with barriers to implementation.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

Spatial-Temporal Characteristics of Semen Quality in Infertile Men in Wenzhou, China during 2010-2018

Xuchao Dai, Mengqi Zhang, Gang Chen, Chengshuang Pan, Jiujia Zheng, Qianjin Fei, Hong Huang, Zhigang Wu

Summary: This study aimed to explore the spatial-temporal characteristics of semen quality in infertile men in Wenzhou from 2010 to 2018. The results showed that there was a linear increase in total sperm number and semen volume, while total sperm motility showed a linear decrease. The main urban area was found to have a more severe decline in semen quality, while the island areas had better semen quality.

ANDROLOGIA (2023)

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Review Andrology

The effect of penile traction device in men with Peyronie's disease on penile curvature, penile length, and erectile dysfunction: a systematic review and meta-analysis

Nazal A. Almsaoud, Omar Safar, Saad Thamer Alshahrani, Raed Alwadai, Sulaiman M. Alkhaldi, Muath Almurayyi, Hana Hazi Alrweili, Hassan M. Assiri, Abdulkareem Al Jubran, Basel Hakami, Meshari A. Alzahrani

Summary: This study systematically reviewed and analyzed the literature on the use of penile traction devices for the treatment of Peyronie's disease. The results suggest that this treatment option can safely and effectively reduce penile curvature.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

Nose Size Predicts Adult Erectile Penile Length

Chunlu Xu, Tao Song, Yutian Dai, Guohai Sun

Summary: Research has found a strong correlation between nose size and both erectile and flaccid penile length, suggesting that nose size may be an independent predictor of penile length and this correlation may develop during fetal development.

ANDROLOGIA (2023)

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Article Andrology

Paternal preconception exposure to non-steroid anti-inflammatory drugs or opioids and adverse birth outcomes: A nationwide registry-based cohort study

Ken Lund, Olav Sivertsen Garvik, Signe Marie Aagaard, Line Riis Jolving, Michael Due Larsen, Per Damkier, Bente Mertz Norgard

Summary: The study investigated the association between paternal use of non-steroid anti-inflammatory drugs and opioids before conception and adverse birth outcomes. Weak associations were found for paternal exposure to these medications and preterm birth/small for gestational age, but not for low Apgar score or major congenital malformations. The effect sizes were small and less likely to be clinically relevant.

ANDROLOGY (2023)

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Review Andrology

Artificial urinary sphincter and female stress urinary incontinence over the past 50 years: a narrative review

Mariana Madanelo, Emmanuel Chartier-Kastler, Tamsin Greenwell, Gary Gray, Rose Khavari, Gommert A. Van Koeveringe, Frank Van Der Aa, Benoit Peyronnet

Summary: The artificial urinary sphincter (AUS) has been used for the treatment of stress urinary incontinence (SUI) in adult females for the past 50 years. Though its application varies across different regions, existing literature demonstrates satisfactory functional outcomes in female SUI patients, and future advancements may expand its role further.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Review Andrology

Assessing psychiatric risk with a focus on optimizing patient satisfaction with penile prosthesis placement-a narrative review

Sevann Helo, Hannah K. Betcher, Matthew Ziegelmann

Summary: Treatment for medication-refractory erectile dysfunction with penile prosthesis placement shows high patient satisfaction rates, but requires appropriate psychological evaluation and patient selection to minimize complications and patient dissatisfaction.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Andrology

Novel ACTL7A variants in males lead to fertilization failure and male infertility

Value of digital rectal examination in patients with suspected prostate cancer: a prospective cohort analysis study

Alterations in testicular positioning after normal descent: acquired cryptorchidism

Sleep duration and biomarkers of fecundity in young men: a cross-sectional study from a population-based cohort

Is SARS-CoV-2-induced disease a decisive factor influencing testosterone in males? Findings from a case-control ex post facto study

Retroperitoneoscopic enucleation adrenalectomy: a viable surgical option for small nonsecreting adrenal tumors with low potential of malignancy

Novel laser therapies and new technologies in the endoscopic management of upper tract urothelial carcinoma: a narrative review

Curcumin Attenuates Ferroptosis and Ameliorates Erectile Function in Diabetic Rats by Activating Nrf2/HO-1 Pathway

Construction of the prognostic model in non-metastatic renal cancer patients with venous tumor thrombus

Host defense amyloids: Biosensors of the immune system?

Pharmacological investigation of vitamin E with combined oral contraceptives on INHBA gene against PCOS that intricate through melatonin PKC pathway

Analysis of prognostic factors in patients diagnosed with bladder cancer complicated by hemorrhage treated by drug-eluting bead embolization

Male contraception: narrative review of ongoing research

Single instillation intravesical chemotherapy after radical nephroureterectomy for upper tract urothelial carcinoma: current evidence and future directions

Spatial-Temporal Characteristics of Semen Quality in Infertile Men in Wenzhou, China during 2010-2018

The effect of penile traction device in men with Peyronie's disease on penile curvature, penile length, and erectile dysfunction: a systematic review and meta-analysis

Nose Size Predicts Adult Erectile Penile Length

Paternal preconception exposure to non-steroid anti-inflammatory drugs or opioids and adverse birth outcomes: A nationwide registry-based cohort study

Artificial urinary sphincter and female stress urinary incontinence over the past 50 years: a narrative review

Assessing psychiatric risk with a focus on optimizing patient satisfaction with penile prosthesis placement-a narrative review

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