Andrology 类别的文章

Article Andrology

Nrf2 enhances the therapeutic efficiency of adipose-derived stem cells in the treatment of neurogenic erectile dysfunction in a rat model

Shangbin Yang, Wancheng Shi, Qianhui Liu, Yingqiu Song, Jiafeng Fang

Summary: This study found that enhancing the expression of Nrf2 can improve the therapeutic effect of ADSCs in the BCNI model, increasing their survival time, restoring nerve structures, improving erectile function, and reducing penile fibrosis.

BASIC AND CLINICAL ANDROLOGY (2023)

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Article Andrology

Which inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie's disease and are there any implications for a better understanding of its mechanisms?

Felice Crocetto, Ciro Imbimbo, Biagio Barone, Davide Turchino, Umberto Marcello Bracale, Antonio Peluso, Marco Panagrosso, Alfonso Falcone, Benito Fabio Mirto, Luigi De Luca, Enrico Sicignano, Francesco Del Giudice, Gian Maria Busetto, Giuseppe Lucarelli, Gaetano Giampaglia, Celeste Manfredi, Matteo Ferro, Giovanni Tarantino

Summary: Peyronie's disease, affecting up to 9% of men, is characterized by inflammation. The NER has been proposed as a new indicator to evaluate its development. Patients showed a higher prevalence of hypercholesterolemia, hyperglycemia, and hypertension, with significantly higher NER values compared to controls.

BASIC AND CLINICAL ANDROLOGY (2023)

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Article Andrology

Reproductive and obstetric outcomes in TESE-ICSI cycles: A comparison between obstructive and non-obstructive azoospermia

Massimo Romano, Federico Cirillo, Noemi Ravaioli, Emanuela Morenghi, Luciano Negri, Bulbul Ozgur, Elena Albani, Paolo Emanuele Levi-Setti

Summary: Despite impaired spermatogenesis in non-obstructive azoospermia patients, there were no substantial differences in reproductive outcomes compared to patients with obstructive azoospermia, even in terms of obstetric safety and neonatal well-being.

ANDROLOGY (2023)

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Article Andrology

SPP1 mRNA determination based on molecular beacon for the recurrence prognosis of bladder cancer

Zhouliang Wu, Donghuai Wang, Yu Zhang, Zhe Zhang, Chong Shen, Zhongcheng Xin, Yuhong Feng, Hailong Hu

Summary: A molecular beacon (MB) for detecting SPP1 messenger RNA was developed in this study, which could predict the recurrence and prognosis of bladder cancer (BC). The results showed that high expression of SPP1 could predict early tumor recurrence in BC.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

The CXCL10/CXCR3 axis regulates Th1 cell differentiation and migration in experimental autoimmune prostatitis through the PI3K/AKT pathway

Shao-Yu Yue, Di Niu, Wen-Ming Ma, Yu Guan, Qiu-Shi Liu, Xiao-Bin Wang, Yun-Zheng Xiao, Jialin Meng, Ke Ding, Li Zhang, He-Xi Du, Chao-Zhao Liang

Summary: The CXCL10/CXCR3 axis regulates Th1 cell differentiation and migration in CP/CPPS through the PI3K/AKT pathway, providing a new perspective on the immunological mechanisms of the syndrome.

ANDROLOGY (2023)

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Article Andrology

Complete or partial loss of the Y chromosome in an unselected cohort of 865 non-vasectomized, azoospermic men

J. Fedder, C. Fagerberg, M. W. Jorgensen, C. H. Gravholt, A. Berglund, U. B. Knudsen, A. Skakkebaek

Summary: This study aimed to determine the prevalence of loss of Y chromosome material within the spectrum ranging from small microdeletions to complete loss of the Y chromosome in azoospermic men. The results showed that Y chromosome loss ranging from small microdeletions to complete loss of the Y chromosome was found in 6.1% of azoospermic men. Partial AZFb microdeletions may give a milder testicular phenotype compared to complete AZFb microdeletions.

BASIC AND CLINICAL ANDROLOGY (2023)

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Article Andrology

Gene methylation status in focus of advanced prostate cancer diagnostics and improved individual outcomes

Weixun Zhang, Song Zeng, Lian Gong, Di Zhang, Xiaopeng Hu

Summary: In this study, an integrative epigenetic analysis was conducted to explore the epigenetic abnormalities in prostate cancer (PCa). A diagnostic model based on DNA methylation profiles was constructed, which showed high accuracy and reliability. This model has the potential to improve early detection and patient outcomes.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

Novel online comprehensive pelvic floor therapy program following prostatectomy

David E. Rapp, Dylan Hutchison, Marieke K. Jones, Anthony DeNovio, Kirsten L. Greene

Summary: This study presents a prospective interim analysis of an online pelvic floor muscle training (PFMT) and pelvic floor education (PFE) program for post-prostatectomy incontinence (PPI). The results show significant improvements in incontinence and quality of life measures, indicating the effectiveness and satisfaction of the online program.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2023)

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Article Andrology

Daily intake of 30 mg duloxetine is effective in decreasing premature ejaculation severity: a prospective randomized placebo-controlled cross over clinical trial

Adham Zaazaa, Mohamed Nasr Eldin, Sameh Fayek GamalEl Din, Ashraf Zeidan, Mohamed Yassin Mohamed Saleh, Ahmed Adel, Mohamed Shokr

Summary: The study demonstrated that duloxetine is effective in treating patients with lifelong premature ejaculation and acquired premature ejaculation. Larger studies are needed to compare duloxetine with other therapeutic modalities for premature ejaculation.

BASIC AND CLINICAL ANDROLOGY (2023)

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Article Andrology

Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction

Alexis N. Roach, Sanat S. Bhadsavle, Samantha L. Higgins, Destani D. Derrico, Alison Basel, Kara N. Thomas, Michael C. Golding

Summary: Chronic paternal alcohol use alters the sperm epigenome, and some epigenetic errors and changes in sperm noncoding RNA content still persist after alcohol withdrawal.

ANDROLOGY (2023)

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Article Andrology

Aging of stallion spermatozoa stored in vitro is delayed at 22°C using a 67 mm glucose-10 mm pyruvate-based media

Laura Becerro-Rey, Francisco Eduardo Martin-Cano, Cristina Ortega Ferrusola, Heriberto Rodriguez-Martinez, Gemma Gaitskell-Phillips, Eva da Silva-Alvarez, Antonio Silva-Rodriguez, Maria Cruz Gil, Fernando J. Pena

Summary: This study investigated the effect of adding pyruvate to glucose extender and storing the seminal doses at 22 degrees C instead of the usual 5 degrees C. The results showed that pyruvate-based media with the addition of itaconate at an appropriate concentration could maintain the motility of sperm samples after 96 hours of storage, which is important for commercialization.

ANDROLOGY (2023)

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Article Andrology

Sperm chromatin structure assay (SCSA®) and flow cytometry-assisted TUNEL assay provide a concordant assessment of sperm DNA fragmentation as a function of age in a large cohort of approximately 10,000 patients

Paria Behdarvandian, Ali Nasr-Esfahani, Marziyeh Tavalaee, Kosar Pashaei, Nushin Naderi, Zahra Darmishonnejad, Jorge Hallak, Robert J. Aitken, Parviz Gharagozloo, Joel R. Drevet, Mohammad Hossein Nasr-Esfahani

Summary: Sperm DNA integrity is crucial for reproductive success, but not yet a routine examination for infertile or fertile men. SDF increases linearly with age, while traditional sperm parameters show minimal changes with aging and are inadequate for assessing fertility potential.

BASIC AND CLINICAL ANDROLOGY (2023)

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Article Andrology

Low human sperm motility coexists with sperm nuclear DNA damage and oxidative stress in semen

Kamil Gill, Tomasz Machalowski, Patryk Harasny, Marta Grabowska, Ewa Duchnik, Malgorzata Piasecka

Summary: This study aimed to investigate the distribution and risk of sperm DNA fragmentation (SDF) and oxidative stress in semen in asthenozoospermic men. The results showed that asthenozoospermic men had lower basic semen parameters compared to the control and nonasthenozoospermic groups. The prevalence and risk of high levels of DNA damage and oxidative stress were significantly higher in men with poor sperm motility. The risk of sperm DNA damage and oxidative stress in asthenozoospermic men was much higher than that in control subjects and nonasthenozoospermic men.

ANDROLOGY (2023)

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Article Andrology

External quality assessment scheme for sperm DNA fragmentation: a pilot study in China

Yan Zheng, Ying-Bi Wu, Ye-Lin Jia, Li-Juan Ying, Ting-Ting Yang, Qing-Yuan Cheng, Jiao Qin, Chen Luo, Lin Yu, Fu-Ping Li

Summary: This article aims to establish an external quality assessment scheme for sperm DNA fragmentation detection and assess the feasibility of the scheme. The results show that there is a large variation among the laboratories participating in the EQA program, and the samples with high SDF values have lower coefficients of variation.

BASIC AND CLINICAL ANDROLOGY (2023)

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Review Andrology

Understanding seminal plasma in male infertility: emerging markers and their implications

Ashutosh Vashisht, Gagandeep Kaur Gahlay

Summary: Infertility is a significant issue for reproductive-aged individuals, with male factors contributing to over 50% of cases. However, current diagnostic tools underestimate the true prevalence of male infertility. Seminal plasma, the carrier of molecules from male reproductive glands, plays a crucial role in reproduction. Researching molecular targets in seminal plasma is important for understanding and diagnosing male infertility.

ANDROLOGY (2023)

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Article Andrology

Association between sleep quality and nocturnal erection monitor by RigiScan in erectile dysfunction patients: a prospective study using fitbit charge 2

Yuyang Zhang, Wei Zhang, Xingliang Feng, Guodong Liu, Xu Wu, Hui Jiang, Xiansheng Zhang

Summary: This study investigated the association between sleep quality and nocturnal erection and found a close relationship between sleep parameters and NPTR parameters. The results emphasize the importance of incorporating sleep monitoring when conducting nocturnal erection monitoring to enhance the reliability of NPTR results.

BASIC AND CLINICAL ANDROLOGY (2023)

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Article Andrology

In Vitro Coexposure of Silymarin with Lithium Chloride Preserves Human Sperm Quality: A Useful Approach to Reduce Oxidative Damages

Zahra Nasimi, Hamid Reza Momeni, Tahereh Etemadi, Niloufar Darbandi

Summary: This study evaluated the effects of silymarin, a potent antioxidant, on human spermatozoa treated with lithium. The results showed that lithium treatment significantly decreased sperm motility and viability, increased oxidative stress levels, and decreased antioxidant enzyme activity. However, coapplication of silymarin with lithium reversed these adverse effects and protected human sperm against oxidative stress-induced damage.

ANDROLOGIA (2023)

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Correction Andrology

ASA Meeting Abstracts 2023 (vol 11, pg 1, 2023)

Roberto Castiglione, Saveria Aquila, Rosario D'Agata

ANDROLOGY (2023)

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Article Andrology

Increased serum creatinine associated with testicular microlithiasis in adult Japanese men: A retrospective cohort study

Jun Hagiuda, Kiyoshi Takamatsu, Ken Nakagawa

Summary: Testicular microlithiasis is associated with a history of testicular tumors and elevated serum creatinine levels. The prevalence of testicular microlithiasis increases with age and patients with testicular microlithiasis tend to have a higher body weight and a higher prevalence of epididymitis.

ANDROLOGY (2023)

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Article Andrology

Dnali1 is required for sperm motility and male fertility in mice

Yiling Zhou, Yaling Wang, Jingwen Chen, Bangguo Wu, Shuyan Tang, Feng Zhang, Chunyu Liu, Lingbo Wang

Summary: This study uncovers the role of the Dnali1 gene in sperm motility and male fertility in mice. It also demonstrates that ICSI can overcome male infertility associated with Dnali1 mutations, providing guidance for the diagnosis and genetic counseling of DNALI1-associated human infertility.

BASIC AND CLINICAL ANDROLOGY (2023)

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Andrology

Nrf2 enhances the therapeutic efficiency of adipose-derived stem cells in the treatment of neurogenic erectile dysfunction in a rat model

Which inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie's disease and are there any implications for a better understanding of its mechanisms?

Reproductive and obstetric outcomes in TESE-ICSI cycles: A comparison between obstructive and non-obstructive azoospermia

SPP1 mRNA determination based on molecular beacon for the recurrence prognosis of bladder cancer

The CXCL10/CXCR3 axis regulates Th1 cell differentiation and migration in experimental autoimmune prostatitis through the PI3K/AKT pathway

Complete or partial loss of the Y chromosome in an unselected cohort of 865 non-vasectomized, azoospermic men

Gene methylation status in focus of advanced prostate cancer diagnostics and improved individual outcomes

Novel online comprehensive pelvic floor therapy program following prostatectomy

Daily intake of 30 mg duloxetine is effective in decreasing premature ejaculation severity: a prospective randomized placebo-controlled cross over clinical trial

Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction

Aging of stallion spermatozoa stored in vitro is delayed at 22°C using a 67 mm glucose-10 mm pyruvate-based media

Sperm chromatin structure assay (SCSA®) and flow cytometry-assisted TUNEL assay provide a concordant assessment of sperm DNA fragmentation as a function of age in a large cohort of approximately 10,000 patients

Low human sperm motility coexists with sperm nuclear DNA damage and oxidative stress in semen

External quality assessment scheme for sperm DNA fragmentation: a pilot study in China

Understanding seminal plasma in male infertility: emerging markers and their implications

Association between sleep quality and nocturnal erection monitor by RigiScan in erectile dysfunction patients: a prospective study using fitbit charge 2

In Vitro Coexposure of Silymarin with Lithium Chloride Preserves Human Sperm Quality: A Useful Approach to Reduce Oxidative Damages

ASA Meeting Abstracts 2023 (vol 11, pg 1, 2023)

Increased serum creatinine associated with testicular microlithiasis in adult Japanese men: A retrospective cohort study

Dnali1 is required for sperm motility and male fertility in mice

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