Allergy

Article Allergy

Hereditary alpha tryptasemia is not associated with specific clinical phenotypes

Madeleine B. Chollet, Cem Akin

Summary: This study found that the prevalence of H alpha T in a random biorepository population was 7.5% and in patients with mastocytosis was 18%. There were no differences in clinical symptomology or medical history between individuals with H alpha T and controls. Elevated baseline serum tryptase was the only consistent phenotypic marker for H alpha T in this study.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis

Vadim Pivniouk, Joao A. Gimenes-Junior, Peace Ezeh, Ashley Michael, Oksana Pivniouk, Seongmin Hahn, Sydney R. VanLinden, Sean P. Malone, Amir Abidov, Dayna Anderson, Justyna Gozdz, Avery DeVries, Fernando D. Martinez, Christian Pasquali, Donata Vercelli

Summary: This study demonstrates that direct administration of OM-85 to the airway compartment can protect against experimental allergic asthma by engaging multiple immune pathways. The efficacy of intranasal OM-85 administration may be due to its direct access to the airway mucosal networks controlling the initiation and development of allergic asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome

Danilo Buonsenso, Michele Piazza, Attilio L. Boner, Joseph A. Bellanti

Summary: Long COVID syndrome is characterized by persistent mild-to-moderate symptoms and medical complications after infection with SARS-CoV-2. This report proposes a model for the pathophysiology of long COVID, suggesting that the persistence of the virus or its molecular components leads to increased production of proinflammatory cytokines. This dysregulated immune response and chronic inflammation are hypothesized to form the basis of the syndrome.

ALLERGY AND ASTHMA PROCEEDINGS (2022)

Review Allergy

Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis

Natsumi Hama, Riichiro Abe, Andrew Gibson, Elizabeth J. Phillips

Summary: Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe delayed T-cell-mediated adverse drug reaction characterized by fever, rash, facial edema, organ involvement, and hematological abnormalities. DIHS/DRESS is associated with the reactivation of chronic persistent human herpesviruses and has a high mortality rate. Identifying potential drug causes and avoiding structurally related drugs is essential. Systemic corticosteroids are the mainstay of treatment with alternative options such as immunosuppressants. HLA class I alleles have been linked to DIHS/DRESS predisposition, providing insights into prevention, risk stratification, and early diagnosis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Article Allergy

Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study

Diego Alvarado, Marcus Maurer, Richard Gedrich, Scott B. Seibel, Michael B. Murphy, Linda Crew, Joel Goldstein, Andrea Crocker, Laura A. Vitale, Pamela A. Morani, Lawrence J. Thomas, Thomas R. Hawthorne, Tibor Keler, Diane Young, Elizabeth Crowley, Martin Kankam, Margo Heath-Chiozzi

Summary: In this study, CDX-0159, an anti-KIT monoclonal antibody, was found to effectively suppress MCs and showed safety and long antibody exposure in healthy volunteers. Importantly, CDX-0159 also demonstrated dose-dependent profound suppression of plasma tryptase, indicating systemic MC suppression or ablation.

ALLERGY (2022)

Review Allergy

Worldwide prevalence of rhinitis in adults: A review of definitions and temporal evolution

Marine Savoure, Jean Bousquet, Jouni J. K. Jaakkola, Maritta S. Jaakkola, Benedicte Jacquemin, Rachel Nadif

Summary: This review summarizes the literature on the prevalence of rhinitis in the general adult population. It found a great heterogeneity in the definitions of rhinitis. Most studies focused on allergic rhinitis, with limited epidemiological data on nonallergic rhinitis. Rhinitis prevalence varied geographically and seemed to increase over time.

CLINICAL AND TRANSLATIONAL ALLERGY (2022)

Review Allergy

Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes

Peter Valent, Amy D. Klion, Florence Roufosse, Dagmar Simon, Georgia Metzgeroth, Kristin M. Leiferman, Juliana Schwaab, Joseph H. Butterfield, Wolfgang R. Sperr, Karl Sotlar, Peter Vandenberghe, Gregor Hoermann, Torsten Haferlach, Richard Moriggl, Tracy George, Cem Akin, Bruce S. Bochner, Jason Gotlib, Andreas Reiter, Hans-Peter Horny, Michel Arock, Hans-Uwe Simon, Gerald J. Gleich

Summary: Eosinophilia and eosinophil activation are common in various diseases. They can lead to hypereosinophilia and hypereosinophilic syndrome, which can cause organ damage. The classification and criteria for these conditions have been widely accepted and regarded as standard since 2012. However, new developments in the field have created a need to update these criteria. A recent working conference on eosinophil disorders discussed new markers and concepts, aiming to improve the diagnosis and management of patients with hypereosinophilia and hypereosinophilic syndrome.

ALLERGY (2023)

Review Allergy

Emollients in infancy to prevent atopic dermatitis: A systematic review and meta-analysis

Youjia Zhong, Miny Samuel, Hugo van Bever, Elizabeth Huiwen Tham

Summary: Prophylactic use of emollients initiated in early infancy may prevent AD, especially in high-risk populations and when used continuously. However, emollients may delay rather than prevent the development of AD. No protective effects on FA were found.

ALLERGY (2022)

Article Allergy

Adverse COVID-19 outcomes in immune deficiencies: Inequality exists between subclasses

Elif Karakoc Aydiner, Sevgi Bilgic Eltan, Royale Babayeva, Omer Aydiner, Eda Kepenekli, Burcu Kolukisa, Asena Pinar Sefer, Ezgi Yalcin Gungoren, Esra Karabiber, Esra Ozek Yucel, Oner Ozdemir, Ayca Kiykim, Hasibe Artac, Nalan Yakici, Koray Yalcin, Haluk Cokugras, Tulin Tiraje Celkan, Fazil Orhan, Mehmet Akif Yesilipek, Safa Baris, Ahmet Ozen

Summary: In this study, 34 IEI patients were evaluated for SARS-CoV-2 infection outcomes, with combined immune deficiency (CID) and immune dysregulation (ID) patients being more susceptible to COVID-19 mortality. Laboratory markers at admission, such as high CRP and low lymphocyte count, were found to predict patients' risk of death.

ALLERGY (2022)

Article Allergy

Humoral immune response of Sinopharm/BBIBP COVID-19 vaccination before and after the booster immunization

Zhangkai J. Cheng, Huimin Huang, Peiyan Zheng, Mingshan Xue, Jing Ma, Zhiqing Zhan, Hui Gan, Yifeng Zeng, Runpei Lin, Shiyun Li, Ruifen Zhong, Siping Li, Hongman Wang, Baoqing Sun

Summary: This study reports on the kinetics, durability, and neutralizing ability of the Sinopharm/BBIBP COVID-19 vaccine-induced immunity, as well as the intensified antibody response elicited by the booster dose. The findings indicate that while antibody levels decline over time, the booster dose leads to a significant increase in antibody levels, indicating enhanced immune protection.

ALLERGY (2022)

Article Allergy

Managing food allergy: GA2LEN guideline 2022

Antonella Muraro, Debra de Silva, Susanne Halken, Margitta Worm, Ekaterina Khaleva, Stefania Arasi, Audrey Dunn-Galvin, Bright Nwaru, Nicolette W. De Jong, Pablo Rodriguez Del Rio, Paul J. Turner, Pete Smith, Philippe Begin, Elizabeth Angier, Hasan Arshad, Barbara Ballmer-Weber, Kirsten Beyer, Carsten Bindslev-Jensen, Antonella Cianferoni, Celine Demoulin, Antoine Deschildre, Motohiro Ebisawa, Maria Montserrat Fernandez-Rivas, Alessandro Fiocchi, Bertine Flokstra-de Blok, Jennifer Gerdts, Josefine Gradman, Kate Grimshaw, Carla Jones, Susanne Lau, Richard Loh, Montserrat Alvaro Lozano, Mika Makela, Mary Jane Marchisotto, Rosan Meyer, Clare Mills, Caroline Nilsson, Anna Nowak-Wegrzyn, Ulugbek Nurmatov, Giovanni Pajno, Marcia Podesta, Lars K. Poulsen, Hugh A. Sampson, Angel Sanchez, Sabine Schnadt, Hania Szajewska, Ronald Van Ree, Carina Venter, Berber Vlieg-Boerstra, Amena Warner, Gary Wong, Robert Wood, Torsten Zuberbier, Graham Roberts

Summary: This article presents guidelines from the Global Allergy and Asthma European Network (GA(2)LEN) for managing food allergy. The guidelines were developed by an international task force using the latest evidence and evaluation methods, and include recommendations such as avoiding allergens, using hypoallergenic formulas, and oral immunotherapy. However, there are still gaps in evidence regarding the safety and effectiveness of these strategies.

WORLD ALLERGY ORGANIZATION JOURNAL (2022)

Article Allergy

S3 guideline Allergy Prevention

M. Kopp, C. Muche-Borowski, M. Abou-Dakn, B. Ahrens, K. Beyer, K. Blumchen, P. Bubel, A. Chaker, M. Cremer, R. Ensenauer, M. Gerstlauer, U. Gieler, I. M. Hubner, F. Horak, L. Klimek, B. Koletzko, S. Koletzko, S. Lau, T. Lob-Corzilius, K. Nemat, E. M. J. Peters, A. Pizzulli, I Reese, C. Rolinck-Werninghaus, E. Rouw, B. Schaub, S. Schmidt, J. O. Steiss, A. K. Striegel, Z. Szepfalusi, D. Schlembach, T. Spindler, C. Taube, V Trendelenburg, R. Treudler, U. Umpfenbach, C. Vogelberg, M. Wagenmann, A. Weissenborn, T. Werfel, M. Worm, H. Sitter, E. Hamelmann

Summary: This article discusses the importance of evidence-based recommendations for primary prevention of allergic diseases. The recommendations from the updated S3 guideline Allergy Prevention are based on extensive research and consultation with experts. The guideline emphasizes the role of maternal and infant nutrition, as well as the avoidance of certain foods and exposure to allergens. It also highlights the importance of reducing air pollution and vaccinating children.

ALLERGOLOGIE (2022)

Article Allergy

Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis

Allyson Mateja, Qinlu Wang, Jack Chovanec, Jiwon Kim, Kenneth J. Wilson, Lawrence B. Schwartz, Sarah C. Glover, Melody C. Carter, Dean D. Metcalfe, Erica Brittain, Jonathan J. Lyons

Summary: Based on the variability of BST, an acute tryptase/BST ratio exceeding 1.685 is the optimized diagnostic rule for distinguishing baseline variability from anaphylaxis, improving specificity among individuals with H alpha T and ISM while maintaining high sensitivity.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma

Antonie Lechner, Fiona D. R. Henkel, Franziska Hartung, Sina Bohnacker, Francesca Alessandrini, Ekaterina O. Gubernatorova, Marina S. Drutskaya, Carlo Angioni, Yannick Schreiber, Pascal Haimerl, Yan Ge, Dominique Thomas, Agnieszka M. Kabat, Edward J. Pearce, Caspar Ohnmacht, Sergei A. Nedospasov, Peter J. Murray, Adam M. Chaker, Carsten B. Schmidt-Weber, Julia Esser-von Bieren

Summary: This study reveals the existence of macrophage-trained immunity in allergic asthma, characterized by inflammatory transcriptional reprogramming and excessive mediator responses. Allergen-triggered inflammation drives a TNF-dependent innate memory, which may perpetuate and exacerbate chronic type 2 airway inflammation and thus represents a target for asthma therapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria

Marcus Maurer, William Berger, Ana Gimenez-Arnau, Koremasa Hayama, Vipul Jain, Adam Reich, Sibylle Haemmerle, Karine Lheritier, Pauline Walsh, Summer Xia, Julian Storim

Summary: Remibrutinib is highly effective in the treatment of CSU, with rapid onset of action and a favorable safety profile.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study

Philippe Gevaert, Jarno De Craemer, Natalie De Ruyck, Sylvie Rottey, Jan de Hoon, Peter W. Hellings, Bram Volckaert, Kristof Lesneuck, Jamie M. Orengo, Amanda Atanasio, Mohamed A. Kamal, Hisham Abdallah, Vishal Kamat, Robert Dingman, Michelle DeVeaux, Divya Ramesh, Lorah Perlee, Claire Q. Wang, David M. Weinreich, Gary Herman, George D. Yancopoulos, Meagan P. O'Brien

Summary: This study tested the efficacy of a Bet v 1-specific antibody cocktail in birch-allergic subjects. The results showed that a single dose of REGN5713/14/15 significantly reduced nasal symptom scores caused by birch allergen challenge, and the reduction was sustained for up to 2 months. In addition, REGN5713/14/15 decreased basophil responsiveness to birch-related allergens.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Use of Dupilumab in 543 Adult Patients With Moderate-to-Severe Atopic Dermatitis: A Multicenter, Retrospective Study

E. Nettis, S. M. Ferrucci, M. Ortoncelli, G. Pellacani, C. Foti, E. Di Leo, C. Patruno, F. Rongioletti, G. Argenziano, L. Macchia, S. Tavecchio, M. Napolitano, S. Ribero, L. Bonzano, P. Romita, D. Di Bona, S. P. Nistico, V Piras, G. Calabrese, C. Detoraki, M. Carbonara, G. Fabbrocini

Summary: This study is the broadest real-life study to date on patients with AD treated with dupilumab. We observed more significant improvements induced by dupilumab in adult patients with moderate-to-severe AD than those reported in clinical trials.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Hypersensitivity Reactions to Platinum Agents and Taxanes

Lulu R. Tsao, Fernanda D. Young, Iris M. Otani, Mariana C. Castells

Summary: Hypersensitivity reactions to chemotherapy agents pose a serious challenge in treating patients with preferred or first-line therapies. Allergic reactions through an immunologic mechanism have been established for platinum and taxane agents, and drug desensitization has been proven to be an effective method for safe reintroduction of both chemotherapeutic agents.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

Article Allergy

A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2

Mona O. Mohsen, Ina Balke, Simon Zinkhan, Villija Zeltina, Xuelan Liu, Xinyue Chang, Pascal S. Krenger, Kevin Plattner, Zahra Gharailoo, Anne-Cathrine S. Vogt, Gilles Augusto, Marianne Zwicker, Salony Roongta, Dominik A. Rothen, Romano Josi, Joana J. da Costa, Jan M. Sobczak, Aleksandra Nonic, Lee-Anne Brand, Katja Nuss, Byron Martina, Daniel E. Speiser, Thomas Kuendig, Gary T. Jennings, Senta M. Walton, Monique Vogel, Andris Zeltins, Martin F. Bachmann

Summary: CuMVTT-RBM vaccine candidate is highly immunogenic, inducing high avidity antibodies that show broad cross-reactivity to mutant receptor-binding domains of variants of concern. The production process is simple and the candidate vaccine remains stable for at least 14 months at 4 degrees Celsius.

ALLERGY (2022)

Review Allergy

Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis

Berber Vlieg-Boerstra, Nicolette de Jong, Rosan Meyer, Carlo Agostoni, Valentina De Cosmi, Kate Grimshaw, Gregorio Paolo Milani, Antonella Muraro, Hanneke Oude Elberink, Isabella Pali-Scholl, Caroline Roduit, Mari Sasaki, Isabel Skypala, Milena Sokolowska, Marloes van Splunter, Eva Untersmayr, Carina Venter, Liam O'Mahony, Bright Nwaru

Summary: Nutrient supplementation for the general population appears to have limited effectiveness in preventing respiratory tract infections, with zinc supplementation showing potential protective effects in children in Asia and vitamin D supplementation reducing the incidence of RTIs in adults in North America.

ALLERGY (2022)