Allergy 类别的文章 - Peeref

Review Allergy

Autoimmune chronic spontaneous urticaria

Pavel Kolkhir, Melba Munoz, Riccardo Asero, Marta Ferrer, Emek Kocaturk, Martin Metz, Yi-Kui Xiang, Marcus Maurer

Summary: Chronic spontaneous urticaria (CSU) is a mast cell-driven disease characterized by recurrent wheals and/or angioedema, with two main autoimmune mechanisms: type I autoallergic CSU and type IIb autoimmune CSU. The latter is less common but more severe, and new targeted therapies are under development for CSU treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

In vitro data suggest that Indian delta variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion

Gilles Augusto, Mona O. Mohsen, Simon Zinkhan, Xuelan Liu, Monique Vogel, Martin F. Bachmann

Summary: The study found that newly emerged SARS-CoV-2 variants have higher affinity for the ACE2 receptor and are able to partially bypass immunity generated against the wild-type virus, resulting in increased transmissibility.

ALLERGY (2022)

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Article Allergy

Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study

Philippe Gevaert, Rebecca Saenz, Jonathan Corren, Joseph K. Han, Joaquim Mullol, Stella E. Lee, Randall A. Ow, Rui Zhao, Monet Howard, Kit Wong, Lutaf Islam, Monica Ligueros-Saylan, Theodore A. Omachi, Claus Bachert

Summary: This study confirms the sustained efficacy and safety of omalizumab treatment for chronic rhinosinusitis with nasal polyps for up to one year, which is of significant importance for patients who do not respond to nasal corticosteroids.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Upadacitinib plus topical corticosteroids in atopic dermatitis: Week 52 AD Up study results

Jonathan Silverberg, Marjolein De Bruin-Weller, Thomas Bieber, Weily Soong, Kenji Kabashima, Antonio Costanzo, David Rosmarin, Charles Lynde, John Liu, Amy Gamelli, Jiewei Zeng, Barry Ladizinski, Alvina D. Chu, Kristian Reich

Summary: The study demonstrated that upadacitinib + TCS had long-term maintenance of efficacy and a favorable safety profile in patients with moderate-to-severe atopic dermatitis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper

Annick Barbaud, Lene Heise Garvey, Alessandra Arcolaci, Knut Brockow, Francesca Mori, Cristobalina Mayorga, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Luis Moral, Giovanna Zanoni, Mauro Pagani, Angele Soria, Maja Jost, Jean-Christoph Caubet, Abreu Carmo, Al-Ahmad Mona, Alberto Alvarez-Perea, Sevim Bavbek, Biagioni Benedetta, M. Beatrice Bilo, Natalia Blanca-Lopez, Herrera Gador Bogas, Alessandro Buonomo, Gianfranco Calogiuri, Giulia Carli, Josefina Cernadas, Gabriele Cortellini, Gulfem Celik, Semra Demir, Inmaculada Dona, Adile Berna Dursun, Bernadette Eberlein, Emilia Faria, Bryan Fernandes, Tomaz Garcez, Ignacio Garcia-Nunez, Radoslaw Gawlik, Asli Gelincik, Eva Gomes, Jimmy H. C. Gooi, Martine Grosber, Theo Gulen, Florence Hacard, Cyrille Hoarau, Christer Janson, Sebastian L. Johnston, Lukas Joerg, Secil Kepil Ozdemir, Ludger Klimek, Mitja Kosnik, Marek L. Kowalski, Semanur Kuyucu, Violeta Kvedariene, Jose Julio Laguna, Carla Lombardo, Susana Marinho, Hans Merk, Elisa Meucci, Martine Morisset, Rosa Munoz-Cano, Francesco Murzilli, Alla Nakonechna, Florin-Dan Popescu, Grzegorz Porebski, Anna Radice, Frederico S. Regateiro, Heike Rockmann, Antonino Romano, Ravishankar Sargur, Joaquin Sastre, Kathrin Scherer Hofmeier, Lenka Sedlackova, Marta Sobotkova, Ingrid Terreehorst, Regina Treudler, Jolanta Walusiak-Skorupa, Bettina Wedi, Stefan Wohrl, Mihael Zidarn, Torsten Zuberbier, Ioana Agache, Maria J. Torres

Summary: Background anaphylaxis after COVID-19 vaccination is rare, and its management is not standardized. The authors propose allergy evaluation and prick test for individuals with specific allergy histories, aiming to improve the understanding and management of anaphylaxis to COVID-19 vaccines and facilitate vaccination for people with allergy history.

ALLERGY (2022)

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Article Allergy

Public Health Measures and the Control of COVID-19 in China

Zhangkai Jason Cheng, Zhiqing Zhan, Mingshan Xue, Peiyan Zheng, Jiali Lyu, Jing Ma, Xiaohua Douglas Zhang, Wenting Luo, Huimin Huang, Yong Zhang, Hongman Wang, Nanshan Zhong, Baoqing Sun

Summary: This article summarizes the strategies and measures China has taken in the prevention and control of the COVID-19 pandemic, providing references for other countries in controlling the epidemic. China has implemented aggressive control measures, achieving rapid and effective control of the epidemic and playing a crucial role in promoting the rapid recovery of its economy.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

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Article Allergy

Guidelines for diagnosis, prevention, and treatment of hand eczema

Jacob P. Thyssen, Marie L. A. Schuttelaar, Jose H. Alfonso, Klaus E. Andersen, Irena Angelova-Fischer, Bernd W. M. Arents, Andrea Bauer, Richard Brans, Alicia Cannavo, Wianda A. Christoffers, Marie-Noelle Crepy, Peter Elsner, Manige Fartasch, Francesca Larese Filon, Ana M. Gimenez-Arnau, Margarida Goncalo, Maria G. Guzman-Perera, Carsten R. Hamann, Wolfram Hoetzenecker, Jeanne Duus Johansen, Swen M. John, Amalia C. M. Kunkeler, Suzana Ljubojevic Hadzavdic, Sonja Molin, Rosemary Nixon, Jart A. F. Oosterhaven, Thomas Rustemeyer, Esther Serra-Baldrich, Mili Shah, Dagmar Simon, Christoph Skudlik, Radoslaw Spiewak, Skaidra Valiukeviciene, Angelique N. Voorberg, Elke Weisshaar, Tove Agner

Summary: Hand eczema is a common inflammatory skin disorder. This article aims to update the European Society of Contact Dermatitis guideline on the diagnosis, prevention, and treatment of hand eczema. Consensus was reached for several statements and management strategies through analysis of evidence for therapeutic and preventive interventions using a structured method of developing consensus. The updated guideline should improve the management of hand eczema.

CONTACT DERMATITIS (2022)

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Review Allergy

Mechanisms and pathogenesis of chronic rhinosinusitis

Atsushi Kato, Robert P. Schleimer, Benjamin S. Bleier

Summary: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by inflammation in the upper airways, which can be divided into two main types based on the presence of nasal polyps. The inflammation is characterized by three different endotypes based on the elevation of specific cytokines. The sinonasal epithelium plays a crucial role in the pathogenesis of CRS by acting as a barrier and participating in both innate and adaptive immunity. Further research is needed to fully understand the mechanisms of CRS pathogenesis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes

Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet

Summary: The GINA 2021 report provides evidence-based recommendations for asthma management, emphasizing the benefits of inhaled corticosteroids (ICS) and recommending the use of combination ICS-formoterol in two different tracks. Additional recommendations are provided for adults with moderate-to-severe asthma, with options for add-on therapies such as long-acting muscarinic antagonists and azithromycin. Regular personalized assessment and treatment adjustments are essential across all age groups and severity levels to optimize asthma outcomes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Allergy

An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria

Sabine Altrichter, Petra Staubach, Malika Pasha, Bhupinder Singh, Alan T. Chang, Jonathan A. Bernstein, Henrik S. Rasmussen, Frank Siebenhaar, Marcus Maurer

Summary: This study aimed to evaluate the safety and efficacy of Lirentelimab in patients with chronic urticaria. The results showed that Lirentelimab could improve symptoms and reduce disease activity, demonstrating good clinical efficacy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Montelukast in hospitalized patients diagnosed with COVID-19

Ahsan R. Khan, Christian Misdary, Nikhil Yegya-Raman, Sinae Kim, Navaneeth Narayanan, Sheraz Siddiqui, Padmini Salgame, Jared Radbel, Frank De Groote, Carl Michel, Janice Mehnert, Caleb Hernandez, Thomas Braciale, Jyoti Malhotra, Michael A. Gentile, Salma K. Jabbour

Summary: A retrospective analysis showed that COVID-19 patients treated with montelukast had fewer events of clinical deterioration, suggesting potential clinical activity. Further prospective studies are needed to validate these findings and explore the efficacy of montelukast in treating COVID-19.

JOURNAL OF ASTHMA (2022)

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Article Allergy

Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients

Emma Guttman-Yassky, Yael Renert-Yuval, Jennifer Bares, Margot Chima, Jason E. Hawkes, Patricia Gilleaudeau, Mary Sullivan-Whalen, Giselle K. Singer, Sandra Garcet, Ana B. Pavel, Mark G. Lebwohl, James G. Krueger

Summary: The study findings suggest that treatment of alopecia areata patients with Dupilumab can result in significant improvement, especially for patients with atopic dermatitis and high baseline IgE levels. Patient selection based on baseline serum IgE levels may enhance treatment outcomes.

ALLERGY (2022)

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Review Allergy

Innovation in the treatment of atopic dermatitis: Emerging topical and oral Janus kinase inhibitors

Chisa Nakashima, Shigeto Yanagihara, Atsushi Otsuka

Summary: Atopic dermatitis is a chronic, eczematous skin condition characterized by severe itchiness. Th2 cell-mediated immunity, skin barrier dysfunction, and pruritus contribute to the development of atopic dermatitis. The JAK/STAT pathway is involved in various inflammatory diseases, including atopic dermatitis. JAK inhibitors show promise as potential treatments for severe atopic dermatitis.

ALLERGOLOGY INTERNATIONAL (2022)

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Article Allergy

Applying Artificial Intelligence to Identify Common Targets for Treatment of Asthma, Eczema, and Food Allergy

Hei Man Liu, Andre Rayner, Andrew R. Mendelsohn, Anastasia Shneyderman, Michelle Chen, Frank W. Pun

Summary: The study dissects the shared pathophysiology of allergic disorders and demonstrates the power of artificial intelligence in exploring novel therapeutic targets.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2023)

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Review Allergy

Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis

Paul J. Turner, Stefania Arasi, Barbara Ballmer-Weber, Alessia Baseggio Conrado, Antoine Deschildre, Jennifer Gerdts, Susanne Halken, Antonella Muraro, Nandinee Patel, Ronald Van Ree, Debra de Silva, Margitta Worm, Torsten Zuberbier, Graham Roberts

Summary: This study summarizes the latest evidence on risk factors for severe food-induced allergic reactions. The study found significant uncertainties in predicting severe reactions and identified some molecular allergology markers that may be helpful. Age was identified as an important factor in severe reactions, but the contribution of risk-taking behavior remains unclear.

ALLERGY (2022)

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Review Allergy

Allergen immunotherapy and/or biologicals for IgE-mediated food allergy: A systematic review and meta-analysis

Debra de Silva, Pablo Rodriguez del Rio, Nicolette W. de Jong, Ekaterina Khaleva, Chris Singh, Anna Nowak-Wegrzyn, Antonella Muraro, Philippe Begin, Giovanni Pajno, Alessandro Fiocchi, Angel Sanchez, Carla Jones, Caroline Nilsson, Carsten Bindslev-Jensen, Gary Wong, Hugh Sampson, Kirsten Beyer, Mary-Jane Marchisotto, Montserrat Fernandez Rivas, Rosan Meyer, Susanne Lau, Ulugbek Nurmatov, Graham Roberts

Summary: Oral immunotherapy improves tolerance in patients with peanut, cow's milk, and hen's egg allergy during therapy and is likely safe. The effects of other allergies and administration routes are inconclusive and require further research.

ALLERGY (2022)

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Article Allergy

Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status

Shigeharu Fujieda, Shoji Matsune, Sachio Takeno, Nobuo Ohta, Mikiya Asako, Claus Bachert, Tomoyuki Inoue, Yoshinori Takahashi, Hiroyuki Fujita, Yamo Deniz, Paul Rowe, Benjamin Ortiz, Yongtao Li, Leda P. Mannent

Summary: Dupilumab consistently improved symptoms of severe CRSwNP in all ECRS subgroups, regardless of ECRS status. Blood eosinophil level may not be a suitable biomarker for dupilumab efficacy in CRSwNP.

ALLERGY (2022)

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Article Allergy

Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19

Lauren E. Eggert, Ziyuan He, William Collins, Alexandra S. Lee, Gopal Dhondalay, Shirley Y. Jiang, Jessica Fitzpatrick, Theo T. Snow, Benjamin A. Pinsky, Maja Artandi, Linda Barman, Rajan Puri, Richard Wittman, Neera Ahuja, Andra Blomkalns, Ruth O'Hara, Shu Cao, Manisha Desai, Sayantani B. Sindher, Kari Nadeau, R. Sharon Chinthrajah

Summary: The study found that asthma is not a risk factor for more severe COVID-19 disease, with allergic asthmatics having a lower risk of hospitalization compared with non-allergic asthmatics. Lower levels of eosinophil counts were associated with a more severe COVID-19 disease trajectory. Recovery time was similar among asthmatics and non-asthmatics, with over 50% of patients reporting ongoing lower respiratory symptoms three months post-infection.

ALLERGY (2022)

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Article Allergy

Hypersensitivity reactions to chemotherapy: an EAACI Position Paper

Mauro Pagani, Sevim Bavbek, Emilio Alvarez-Cuesta, Adile Berna Dursun, Patrizia Bonadonna, Mariana Castells, Josefina Cernadas, Anca Chiriac, Hamadi Sahar, Ricardo Madrigal-Burgaleta, Soledad Sanchez Sanchez

Summary: Chemotherapeutic drugs can induce hypersensitivity reactions, being the third leading cause of fatal drug-induced anaphylaxis. Deaths related to chemotherapy have been reported in Europe and the United States. The European Network on Drug Allergy organized a task force to provide data and recommendations regarding allergological work-up in this field.

ALLERGY (2022)

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Article Allergy

Effect of Dupilumab on Blood Eosinophil Counts in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis, or Eosinophilic Esophagitis

Michael E. Wechsler, Amy D. Klion, Pierluigi Paggiaro, Parameswaran Nair, Delphine Staumont-Salle, Amr Radwan, Robert R. Johnson, Upender Kapoor, Faisal A. Khokhar, Nadia Daizadeh, Zhen Chen, Elizabeth Laws, Benjamin Ortiz, Juby A. Jacob-Nara, Leda P. Mannent, Paul J. Rowe, Yamo Deniz

Summary: Transient increases in eosinophil counts have been observed in dupilumab clinical trials, but they do not affect efficacy and are rarely associated with clinical consequences.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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