Allergy

Article Allergy

Sublingual immunotherapy with customized allergy drops in routine practice France: Which patients and for what reasons?

I. Bosse, M. Migueres, S. Saf, S. Amet, M. Giraud-Morel, A. Chartier

Summary: This study aimed to investigate the circumstances and reasons for prescribing named-patient products (NPPs) when initiating allergen immunotherapy (AIT) in mainland France. The results showed that a significant proportion of patients in the registry were prescribed AIT for rhinitis, conjunctivitis, and/or associated asthma, with a considerable number of patients exclusively receiving NPPs. The main reasons for choosing NPPs were dosage flexibility, unavailability of tablet form, and indications not being available. Despite allergen tablets being the preferred choice, NPPs continue to play an important role in the treatment of respiratory allergies in France's clinical practice.

REVUE FRANCAISE D ALLERGOLOGIE (2024)

Article Allergy

Grass pollen allergen immunotherapy: Safety and efficacy profile

S. Daboussi, M. Chaabane, S. Mhamdi, A. Saidane, C. Aichaouia, I. E. Ben Dhia, S. Toujani, Z. Moatemri

Summary: Grass pollen allergen immunotherapy is an effective and safe treatment for allergic diseases, improving symptoms and quality of life for patients.

REVUE FRANCAISE D ALLERGOLOGIE (2024)

Article Allergy

Impact of global warming on asthma and allergy in children

F. Amat, A. Labbe

Summary: Global warming has health consequences that are particularly worrying for children, especially during their early growth stages. The loss of biodiversity may be one of the reasons for the increased frequency of allergic diseases. It is important for us to propose solutions to adapt to the changing environment and reverse this trend through reasoned practices.

REVUE FRANCAISE D ALLERGOLOGIE (2024)

Article Allergy

Epicutaneous and sublingual immunotherapy: Efficacy, tolerance and place in the management of food allergy

C. Braun, P. Begin

Summary: Oral immunotherapy (OIT) is the only practical treatment for inducing tolerance in food-allergic patients, but adverse events often lead to treatment refusal or discontinuation. Epicutaneous (EPIT) and sublingual (SLIT) immunotherapies, developed concurrently with OIT, share immunological principles and expose patients to lower allergen doses. EPIT and SLIT are well tolerated and have a lower risk of severe allergic reactions compared to OIT.

REVUE FRANCAISE D ALLERGOLOGIE (2024)

Article Allergy

Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy

Astrid L. Voskamp, Sugandhika Khosa, Tracy Phan, Hannah A. Deberg, Judy Bingham, Mark Hew, William Smith, Jodie Abramovitch, Jennifer M. Rolland, Matthew Moyle, Kari C. Nadeau, Gideon Lack, Mark Larche, Erik Wambre, Robyn E. O'Hehir, Pascal Hickey, Sara R. Prickett

Summary: PVX108, a peptide immunotherapy designed to treat peanut allergy, showed negligible activation of peanut-sensitized basophils and induced a shift in peanut-reactive T-cell phenotype balance to reduce Th2A dominance in a randomized, placebo-controlled Phase 1 clinical trial in peanut-allergic adults.

ALLERGY (2023)

Article Allergy

Gender differences in allergic contact dermatitis to common allergens

Waranya Boonchai, Surachanee Likittanasombat, Noldtawat Viriyaskultorn, Silada Kanokrungsee

Summary: The study found that females had a higher positive patch test rate than males, but males were more likely to develop occupationally related allergic contact dermatitis. Gender plays a pivotal role in contact dermatitis.

CONTACT DERMATITIS (2023)

Letter Allergy

Hypersensitivity reactions to human albumin-A case series and diagnostic algorithm

Millie Nguyen Basu, Birgitte Bech Melchiors, Charlotte G. Mortz, Lene H. Garvey

ALLERGY (2023)

Letter Allergy

Children with asthma and eczema carrying filaggrin loss-of-function mutations have increased antibiotic use through to adulthood

Ciara Holden, Patricia Soares, Katy Fidler, Roger Tavendale, Jessie Felton, Somnath Mukhopadhyay

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

Article Allergy

Contact allergy to acrylate-containing nail cosmetics: A retrospective 8-year study

Iemke M. Steunebrink, Anton de Groot, Thomas Rustemeyer

Summary: The study investigated the frequency and clinical features of allergic contact dermatitis (ACD) caused by acrylate-containing nail cosmetics in a university hospital in Amsterdam, The Netherlands. The results showed that this condition is common in women, with most individuals being allergic to 2-hydroxyethyl methacrylate (HEMA), and avoidance of acrylate-containing products can effectively relieve the symptoms.

CONTACT DERMATITIS (2023)

Article Allergy

Understandability and Actionability of Audiovisual Patient Education on Epinephrine Auto-Injector

Gurgun Tugce Vural Solak, Merve Erkoc, Yavuzalp Solak

Summary: The internet and social media are important platforms for obtaining health information, but the reliability and quality of the videos on Youtube regarding the use of epinephrine auto-injectors need improvement.

ASTHMA ALLERGY IMMUNOLOGY (2023)

Letter Allergy

Reply to correspondence to 'association between chronic rhinosinusitis and new onset asthma implications for prevention'

Brian S. Schwartz, Annemarie G. Hirsch, Karen Bandeen-Roche, Atsushi Kato, Robert Schleimer

ALLERGY (2023)

Article Allergy

Re-Administration Experience Following Allergic Reaction After Vaccination with BNT162b2 mRNA COVID-19

Buket Basa Akdogan, Hasibe Aytac, Saltuk Bugra Kaya

Summary: This study aimed to establish a successful re-administration protocol for patients who experienced allergic reactions to the first dose of the vaccine and safely vaccinate as many people as possible. By evaluating nine patients and conducting allergy skin tests, it was found that gradual dose increase/desensitization was effective in re-administering the vaccine.

ASTHMA ALLERGY IMMUNOLOGY (2023)

Article Allergy

Acrylates in artificial nails-Results of product analyses and glove penetration studies

Katri Suuronen, Katriina Ylinen, Jaakko Heikkila, Erja Makela, Raija Vastapuu, Kristiina Aalto-Korte, Maria Pesonen

Summary: This study chemically analyzed the (meth)acrylate content in 31 gel nail products and 6 acrylic nail products, and compared the results with the information on product labels. The penetration of artificial nail materials through disposable gloves was also tested. The labeling of most artificial nail products was found to be incorrect, and disposable gloves were not effective in protecting against acrylic nail liquids.

CONTACT DERMATITIS (2023)

Article Allergy

Occupational anaphylaxis-Data from the anaphylaxis registry

Margitta Worm, Veronika Hoefer, Sabine Doelle-Bierke, Maria Beatrice Bilo, Karin Hartmann, Dominique Sabouraud-Leclerc, Regina Treudler

Summary: Epidemiologic data on occupational anaphylaxis is scarce, but this study provides valuable insights into the elicitors, demographics, severity, and management of occupational anaphylactic episodes. The majority of cases were caused by insects, followed by food and drugs. Beekeepers, gardeners, farmers, and individuals working in food-related professions were most frequently affected. More research is needed to determine risk factors associated with occupational anaphylaxis.

ALLERGY (2023)

Letter Allergy

Switching from omalizumab to mepolizumab in severe asthmatics: A post hoc analysis of the RELight study

Maria Kallieri, Andriana I. Papaioannou, Eleftherios Zervas, Evangelia Fouka, Konstantinos Porpodis, Marija Hadji Mitrova, Eleni Tzortzaki, Michael Makris, Maria Ntakoula, Panagiotis Lyberopoulos, Katerina Dimakou, Sofia Koukidou, Sevasti Ampelioti, Anastasia Papaporfyriou, Konstantinos Katsoulis, Maria Kipourou, Nikoletta Rovina, Katerina Antoniou, Stylianos Vittorakis, Petros Bakakos, Paschalis Steiropoulos, Katerina Markopoulou, Panteleimon Avarlis, Ilias C. Papanikolaou, Miltiadis Markatos, Eleni Gaki, Konstantinos Samitas, Konstantinos Glynos, Spyros A. Papiris, Despoina Papakosta, Nikolaos Tzanakis, Mina Gaga, Konstantinos Kostikas, Stelios Loukides

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

Article Allergy

Effect-modifying impact of age on sex-based differences during oral immunotherapy

Charles Elbany, Camille Braun, Selma Lazizi, Louis Paradis, Anne Des Roches, Kathryn Samaan, Roxane Labrosse, Francois Graham, Philippe Begin

ALLERGY (2023)

Review Allergy

The T-Cell Growth Factor Interleukin-2, Which Is Occasionally Targeted by Autoantibodies, Qualifies as Drug for the Treatment of Allergy, Autoimmunity, and Cancer: Collegium Internationale Allergologicum (CIA) Update 2024

Al Nasar Ahmed Sehgal, Peter A. Tauber, Robert B. Stieger, Bernhard Kratzer, Winfried F. Pickl

Summary: This review discusses the peculiar structural and functional aspects of interleukin (IL)-2, and the innovative advancements in tailoring its multifaceted functional behavior for targeting different IL-2 receptor types. The article also introduces modified versions of IL-2, obtained by mutation, fusion with heterologous molecules, or forming complexes with antibodies, and discusses their implications in cancer, autoimmunity, and allergy. Furthermore, the review sheds light on the contribution of autoantibodies to the regulation of IL-2 in both health and disease. Ongoing efforts to fine-tune IL-2 responses through antibody-dependent targeting or molecular engineering offer promising translational potential for this important cytokine in the future.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2023)

Article Allergy

Late-Onset Chronic Localized Urticaria After a Wasp Sting

Bulent Akkurt, Efe Emre Kasikci, Muhammet Yildirim, Ozan Ucar, Zeynep Peker Koc, Papatya Degirmenci, Secil Kepil Ozdemir

Summary: This study presents a very rare case of late-onset chronic localized urticaria after a wasp sting. The past history of wasp or bee stings should be questioned in cases of localized urticaria.

ASTHMA ALLERGY IMMUNOLOGY (2023)

Article Allergy

Risk of anaphylaxis after COVID-19 vaccination in South Korea: A nationwide self-controlled case series analysis

Dongwon Yoon, Ju Hwan Kim, Han Eol Jeong, Hwa Yeon Ko, Sung-Ryeol Kim, Ju-Young Shin

ALLERGY (2023)

Review Allergy

Changing patterns in the epidemiology of drug allergy

Immaculada Dona, Maria Jose Torres, Gulfem Celik, Elizabeth Phillips, Luciana Kase Tanno, Mariana Castells

Summary: Drug allergy is a complex and unresolved problem worldwide, posing risks to patients' medication choices and life safety. Lack of standardized definitions and biomarkers leads to underdiagnosis and overdiagnosis. Although the true burden of drug allergies is still unknown, data gathering through electronic medical records is providing emerging global patterns.

ALLERGY (2023)