期刊
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
卷 96, 期 2, 页码 323-327出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2010.031161
关键词
chronic lymphocytic leukemia; epidemiology; Epstein Barr virus; interaction; polymorphism
类别
资金
- European Commission [QLK4-CT-2000-00422]
- Association pour la Recherche contre le Cancer (ARC) [5111]
- Fondation de France [1999 008471]
- Compagnia di San Paolo di Torino
- Italian Ministry of Education, University and Research
- Spanish Ministry of Health [PI040091, RCESP 03/09]
- Marato TV3 [051210]
- German Federal Office for Radiation Protection [StSch4261, StSch4420]
- Foundation Genoma Espana
Using EpiLymph case-control data, we found that chronic lymphocytic leukemia patients were more likely to have abnormal reactive serological patterns to Epstein Barr virus than controls. Here, we aimed to assess whether this association is modified by genetic variants. We examined 1,305 Single Nucleotide Polymorphisms from 300 selected genes related to various pathways in 240 cases and 513 controls from five European centers. In a recessive model, patients positive to aberrant antibody pattern and homozygous for rare genotypes in rs8113877T > G or rs17576A > G of the MMP9 gene were at highest risk of chronic lymphocytic leukemia. In a dominant model, TP73 showed the highest risk in patients positive to aberrant antibody pattern and homozygous for the wild-type genotype in rs1885859G > C or rs3765701A > T. All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted.
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