期刊
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
卷 95, 期 3, 页码 505-508出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2009.013136
关键词
iron; hepcidin; erythropoietin; GDF15; ferritin; anemia of chronic disease
类别
资金
- Hammersmith Hospitals Trustees Research Committee
- UK Medical Research Council
- NIHR Biomedical Research Centre Funding Scheme
- National Institute for Health Research [NF-SI-0507-10315] Funding Source: researchfish
Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia in a manner which appears dependent on increased bone marrow activity. The temporal associations between plasma hepcidin and other iron parameters were examined in healthy humans after erythropoietin administration and venesection. Profound hepcidin suppression appeared abruptly 24 hours after subcutaneous erythropoietin (P=0.003), and was near maximal at onset, with peak (mid-afternoon) levels reduced by 73.2%, gradually recovering over the following two weeks. Minor changes in circulating iron, soluble transferrin receptor and growth differentiation factor-15 were observed after the reduction in hepcidin. Similar but more gradual changes in these parameters were observed after reducing hematocrit by removal of 250 mL blood. These human studies confirm the importance of a rapidly responsive marrow hepcidin axis in regulating iron supply in vivo, and suggest that this axis is regulated by factors other than circulating iron, soluble transferrin receptor or growth differentiation factor-15.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据