期刊
HAEMATOLOGICA
卷 93, 期 5, 页码 753-756出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.12175
关键词
heme-regulated eIF2 alpha kinase; hepcidin; iron deficiency
类别
资金
- NIH [DK016272, DK066373]
- Cooley's Anemia Foundation
Heme-regulated eIF2 alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2 alpha kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that HRI deficiency does not significantly affect red cell parameters of hemochromatosis (HFE-/(-)) mice. Importantly, heme-regulated eIF2 alpha kinase deficiency exacerbates decreases in hepcidin expression and splenic macrophage iron in HFE-/(-) mice. Furthermore, the serum level of bone morphogenic protein 2, which positively regulates hepcidin, is reduced in heme-regulated eIF2 alpha kinase deficiency, but not in HFE deficiency.
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