期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 29, 期 8, 页码 754-757出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09513590.2013.801443
关键词
AMH; GnRH antagonist; oocyte donor; ovarian response; poor ovarian response
资金
- Catedra de Investigacion en Obstertricia y Ginecologia of the Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Universitat Autonoma de Barcelona
We aimed to establish the reference values of Anti-Mullerian hormone (AMH) in our oocyte donor population and correlate them with the ovarian response to an antagonist stimulation protocol and to study the predictive capacity of AMH for poor response (PR). Normal AMH curves were obtained for 172 candidates. AMH levels decreased with age although they showed great heterogeneity and spread in absolute values at any age range. AMH levels showed a positive correlation, statistically significant, with the Antral Follicle Count (r = 0,705), and number of oocytes retrieved (r = 0,356). In receiver operating characteristic curve analysis a threshold value of AMH = 2.31 ng/ml predictive for retrieval <6 MII (area under the curve (AUC) 0.675) was identified. This cut-off predicted PR with a sensitivity of 70.4% and a specificity of 61.8%, (PPV = 39.6%; NPV = 85.5%, p = 0.004). When performing a multiple logistic regression analysis including age, AFC and FSH, an AUC = 0.668 for PR was obtained whereas if AMH was added to the model it resulted in an AUC = 0.713. In oocyte donors aged 18 to 35 with an AFC >= 10 and basal FSH <10 mIU/ml, measuring AMH levels improved just slightly the prediction for PR.
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