期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 26, 期 10, 页码 743-748出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09513590.2010.487592
关键词
Polycystic ovary syndrome; PAI-1; tPA; obesity; free androgen index
资金
- Family Planning Foundation
- Selander Foundation
- Utvecklingsfonden Uppsala University Hospital
- Visare Norr
Objective. Disturbances in the fibrinolytic system are predictors of future cardiovascular events. The aim of this study was to compare plasminogen activator inhibitor 1 (PAI-1) activity and tissue plasminogen activator (tPA) mass concentration between patients with polycystic ovary syndrome (PCOS) and control subjects. Design. One hundred thirty-five patients with PCOS (lean and obese) and 81 healthy controls were recruited for the study. Blood samples for PAI-1 activity and tPA mass were collected together with anthropometric measures. Results. Obese patients with PCOS displayed increased tPA mass concentration in comparison with controls (p<0.05), and this finding was consistent regardless of whether patients displayed signs of hyperandrogenism or not. When hyperandrogenism was introduced as a prerequisite for the PCOS diagnosis, obese patients with PCOS displayed increased PAI-1 activity as well, p<0.05. Lean patients with PCOS did not differ in terms of PAI-1 activity or tPA mass concentration in comparison to controls. Conclusion. Obese women with PCOS have impaired fibrinolysis, in particular if they also display objective biochemical markers of hyperandrogenism.
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