期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 24, 期 11, 页码 620-624出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590802288283
关键词
Isoflavones; Trifolium pratense; red clover; dyslipidemia; cardiovascular risk; obesity
资金
- Melbrosin International
- Produktions und Vertriebs GmbH & Co. KG, Vienna, Austria
Background. Since current clinical evidence indicates that conventional estrogen hormone therapy (HT) increases cardiovascular risk, alternatives to estrogens are growing in popularity, especially among high-risk populations. Objective. To determine the effect of Trifolium pratense-derived isoflavone supplementation on the lipid profile of postmenopausal women with increased body mass index (BMI). Methods. Sixty postmenopausal women aged40 years, HT non-users, were randomly assigned to one of two groups: either two capsules of T. pratense (80mg red clover isoflavones) daily for a 90-day period or placebo of equal design. After a 7-day washout period, medication was crossed-over for another 90 days. Total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C) and lipoprotein A (LpA) levels were assessed at baseline, 90 and 180 days. Women were divided into two groups: those with increased BMI (25kg/m2) and those with BMI25kg/m2. Results. Fifty-three women (88.3%) completed the trial. T. pratense isoflavone supplementation had a positive effect on the lipid profile of women with increased BMI, evidenced by a significant decrease in TC, LDL-C and LpA levels. Conclusions. Isoflavones derived from T. pratense are an attractive alternative therapeutic option for high-risk populations such as postmenopausal women with increased BMI and abnormal lipid profile.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据