期刊
GYNECOLOGIC ONCOLOGY
卷 111, 期 2, 页码 226-232出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2008.07.018
关键词
BRCA; p53; Fallopian tube neoplasms; Serous carcinoma; Ovarian neoplasms; Fimbria
资金
- NCI [P50 CA 105009, KO8 CA 108748, 1R21CA124688-01A1]
- Columbia Hospital For Women Research Foundation
- Francis Ward Paine
- Division of Women's and Perinatal Pathology
- Brigham arid Women's Hospital
Objectives. Pelvic (ovarian) serous carcinomas frequently contain p53 Mutations. Recently, a candidate serous cancer precursor (the p53 signature with p53 mutations and other features in common with serous cancer has been discovered in distal fallopian tube mucosa. This study examined the relationship of putative ovarian cancer risk factors with the presence of p53 signatures in women with BRCA mutations (BRCA+). Methods. Fallopian tubes from 75 BRCA+ women were immunostained for p53 signatures and correlated with age at first childbirth, parity, oral contraceptive use, body mass index (BMI), and BRCA subtype (1 or 2). Statistical analysis was performed with the T-test or Chi-square analysis and logistic regression adjusting for age and parity. Results. Thirty-eight percent of the tubes contained p53 signatures, which were significantly associated with older age at first childbirth (mean 30.8 vs. 28.4 years; p = 0.04) and lower parity (mean 1.4 vs. 2.2: p=0.01) in univariate analyses. The unadjusted odds ratios were 3.8 (p-trend=0.04) for first childbirth >= 30 years versus <30 and 0.2 (p-trend=0.01) for parity >= 3 versus nulliparous women. After adjusting for age and parity, the trend for age at first childbirth became non-significant (adjusted odds ratio 3.5: p-trend=0.15). while that for parity remained significant (adjusted odds ratio 0.2; p-trend 0.02). Conclusions. The p53 signature is significantly associated with lower parity and possibly higher age at first childbirth. further linking this entity to serous cancer via risk factors associated with ovulation. The p53 signature merits consideration as a surrogate marker for serous cancer risk. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据