期刊
GUT AND LIVER
卷 8, 期 3, 页码 237-241出版社
EDITORIAL OFFICE GUT & LIVER
DOI: 10.5009/gnl.2014.8.3.237
关键词
Alcoholic liver injury; Microbiota; Permeability; Metabolism
资金
- National Institutes of Health [K08 DK081830, R01 AA020703, U01 AA021856]
- ABMRF/The Foundation for Alcohol Research
Alcoholic liver disease is a leading cause of morbidity and liver-related death worldwide. Intestinal bacterial overgrowth and dysbiosis induced by ethanol ingestion play an important role in the pathogenesis of alcoholic liver disease. After exposure to alcohol in the lumen, enteric bacteria alter their metabolism and thereby disturb intestinal homeostasis. Disruption of the mucosal barrier results in the translocation of microbial products that contribute to liver disease by inducing hepatic inflammation. In this review, we will discuss the effects of alcohol on the intestinal microbiome, and in par: ticular, its effects on bacterial metabolism, bacterial translocation and ecological balance. A better understanding of the interaction among alcohol, the host and the microbiome will reveal new targets for therapy and lead to new treatments.
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