期刊
GUT AND LIVER
卷 6, 期 1, 页码 10-20出版社
EDITORIAL OFFICE GUT & LIVER
DOI: 10.5009/gnl.2012.6.1.10
关键词
Gut hormones; Appetite; Peptide tyrosine tyrosine; Glucagon-like peptide 1; Obesity
资金
- MRC [G7811974] Funding Source: UKRI
- Medical Research Council [G7811974] Funding Source: researchfish
- Medical Research Council [G7811974] Funding Source: Medline
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed. (Gut Liver 2012;6:10-20)
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