期刊
GROWTH HORMONE & IGF RESEARCH
卷 19, 期 4, 页码 408-411出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2009.04.017
关键词
IGF-I; GH; Sport; Abuse; Doping
资金
- United States Anti-Doping Agency
- World Anti-Doping Agency
As the tests for detecting growth hormone (GH) abuse develop further, it is likely that athletes will turn to doping with insulin-like growth factor-I (IGF-I). IGF-I mediates many of the anabolic actions of growth hormone. It stimulates muscle protein synthesis, promotes glycogen storage and enhances lipolysis, all of which make IGF-I attractive as a potential performance-enhancing agent. Pharmaceutical companies have developed commercial preparations of recombinant human IGF-I (rhIGF-I) for use in disorders of growth. The increased availability of rhIGF-I increases the opportunity for athletes to acquire supplies of the drug on the black market. The long-term effects of IGF-I administration are currently unknown but it is likely that these will be similar to the adverse effects of chronic GH abuse. The detection of IGF-I abuse is a challenge for anti-doping organisations. Research has commenced into the development of a test for IGF-I abuse based on the measurement of markers of GH action. Simultaneously, the effects of rhIGF-I on physical fitness, body composition and substrate utilisation in healthy volunteers are being investigated. (C) 2009 Elsevier Ltd. All rights reserved.
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