期刊
GROWTH HORMONE & IGF RESEARCH
卷 19, 期 6, 页码 478-485出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2009.03.002
关键词
Branched-chain amino acids; High-protein diet; Maternal nutrition; Fetal growth; Insulin-like growth factors
资金
- Ministry of Education, Science, Culture and Sports, Japan [15659393, 16390475, 17390450, 17591728, 17591730, 17659513, 18390446]
- Ministry of Health, Labor and Welfare
- Smoking Research Foundation
- Takeda Science Foundation
- Takeda Medical Research Foundation
- Naito Foundation
- Uehara Memorial Foundation
- Food Science Institute Foundation
- Precursory Research for Embryonic Science and Technology (PRESTO)
- Japan Science and Technology Agency (JST)
- Grants-in-Aid for Scientific Research [15659393, 17591728, 18390446, 17390450, 17591730, 17659513, 16390475, 21592094] Funding Source: KAKEN
Maternal undernutrition causes fetal growth restriction. Protein is a vital dietary nutrient for fetal growth, and branched-chain amino acids (BCAA) are noted to have anabolic actions. In this study, we investigated the effects of maternal high-protein diet or BCAA-supplemented diet upon fetal growth under the condition of maternal calorie restriction. Pregnant mice were calorie-restricted (undernutrition: UN), using either a standard diet (S-UN group), high-protein diet (HP-UN group), or BCAA-supplemented diet (BCAA-UN group) to 70% of the control; dams fed ad libitum with a standard diet (S-NN group) from 10.5 days Post coitum (dpc) to 18.5 dpc. The fetal weights of UN groups were significantly decreased compared to that of S-NN. However, the fetal weights of HP-UN and BCAA-UN were significantly higher by 5% and 4%, respectively, than those of S-UN, concomitant with augmentation of the gene and protein expressions of IGF-I and IGF-II in fetal liver. A high-protein diet as well as BCAA-supplemented diet partially improved fetal growth restriction caused by maternal calorie-restriction, suggesting a pivotal role of them in the amelioration of fetal growth restriction. (C) 2009 Elsevier Ltd. All rights reserved.
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