期刊
GROWTH FACTORS
卷 32, 期 6, 页码 176-189出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08977194.2014.982276
关键词
Cancer; cell-cell interaction; eph receptor; ephrin
Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.
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