期刊
GREEN CHEMISTRY
卷 20, 期 18, 页码 4287-4291出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8gc02051e
关键词
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资金
- National Natural Science Foundation of China [21772161, 21622204, 21572186, 91545105]
- Xiamen University [20720180036]
- NFFTBS [J1310024]
- PCSIRT
Herein, we disclose an efficient zinc-catalyzed formal [3 + 2] annulation of isoxazoles with ynol ethers under exceptionally mild reaction conditions, leading to the atom-economical and divergent synthesis of 2-alkoxyl 1H-pyrroles and 3H-pyrroles, respectively. Importantly, this zinc-catalyzed protocol demonstrates the dramatically divergent reactivity from the relevant platinum catalysis, where the formal [4 + 2] annulation of isoxazoles with ynol ethers was involved. In addition, theoretical calculations provide further evidence for the feasibility of the proposed reaction mechanism, especially the distinct selectivity.
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