期刊
GREEN CHEMISTRY
卷 15, 期 2, 页码 453-462出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc36552a
关键词
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资金
- National Natural Science Foundation of China [81160384, 21162037, 21262042, U1202221]
- Natural Science Foundation of Yunnan Province [2009CC017, 2011Z042, 2009B08Q, K1050669, 2011J021, 2010120303]
A concise and efficient one-pot regio- and stereoselective synthesis of structurally diverse spirooxindoles was constructed by simply refluxing a mixture of different types of heterocyclic ketene aminals, isatins and ethyl trifluoroacetate using catalytic piperidine. The advantages of this method include high efficiency, mild reaction conditions and environmentally benign reagents. These spirooxindoles are promising candidates for drug discovery; consequently, a library of diverse spirooxindoles was rapidly constructed using the present protocol.
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