期刊
GREEN CHEMISTRY
卷 15, 期 5, 页码 1368-1372出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3gc40185e
关键词
-
资金
- Sudzucker AG
- Mannheim/Ochsenfurt
- Ministry of Nutrition, Agriculture and Forestry, Bonn [94 NR 078-F, 99 NR 063]
Carbohydrates, as cheap mass-products, promise to be outstanding candidates as sustainable raw materials (F. W. Lichtenthaler and S. Peters, C. R. Chim., 2004, 7, 65-90). To achieve the goal of carbohydrate utilisation as industry raw materials, environmental low impact conversions from sugars to high value reactive intermediates are needed. Here we present the facile access to.-keto-carboxylic acid building blocks from the sucrose-based glycosyloxymethyl-furfural (GMF). Employing an oxidative ring opening strategy under careful selection of reaction conditions, allows for high yield conversions of the furan aglycon into.-keto-carboxylic acid moieties without alteration of the sugar moiety attached. The resulting glycosylated building blocks were converted into selected heterocyclic products of the pyridazinone and benzodiazepinone type to exemplify the synthetic potential of these building blocks. All synthetic manipulations employed low environmental impact solvents, reagents, oxidants and protecting group free conversions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据