Aqueous solutions of facial amphiphilic carbohydrates as sustainable media for organocatalyzed direct aldol reactions

The organocatalyzed direct aldol reaction was efficiently performed in aqueous solutions of facial amphiphilic carbohydrates with high diastereoselectivity and yield. Such sustainable media in addition with the use of 2% catalyst loading paves the way for the development of original ecofriendly procedures through non-covalent induction.