Catalyst-free and catalytic Friedel-Crafts alkylations of indoles in Solkane (R) 365mfc, an environmentally benign alternative solvent

Solkane (R) 365mfc is a proven environmentally benign alternative solvent for catalyst-free Friedel-Crafts (F-C) alkylations of indoles with trifluoropyruvate and glyoxylate. Their enantioselective variants are also achieved by virtue of the high-affinity of fluorous cinchona alkaloids catalysts to Solkane (R) 365mfc to provide F-C adducts in excellent yields with good to excellent ees (up to 96% ee).