An efficient synthesis of dihydrothiophene ureidoformamides by domino reactions of 1,3-thiazolidinedione under catalyst-free conditions

An efficient synthesis of dihydrothiophene ureidoformamides by the domino reactions of aldehydes, malononitrile, amines and 1,3-thiazolidinedione in PEG 400/H2O is studied. The reaction is free of catalysts and toxic solvents, of shorter reaction time and with ease of the product isolation, making it more environmentally friendly and suitable for large-scale operations.