Functional ionic liquid mediated synthesis (FILMS) of dihydrothiophenes and tacrine derivatives

Natural amino acid-based functional ionic liquid [Bz-His(n-propyl)(2)-OMe+Br-] promoted diastereoselective synthesis of dihydrothiophenes is described. Further this functional ionic liquid was efficiently utilized to form tacrine derivatives from dihydrothiophenes using microwave irradiation. The functional ionic liquid exhibits organocatalytic as well as medium engineering capability, thus we named this synthetic protocol functional ionic liquid mediated synthesis (FILMS).