Long term continuous chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol using ionic liquids and supercritical carbon dioxide

The long term continuous dynamic kinetic resolution (DKR) of rac-phenylethanol in IL/scCO(2) biphasic systems was carried out by simultaneously using immobilized lipase (Novozym 435) and acidic zeolite catalysts at 50 degrees C and 100 bar, providing good yields (up to 98.0%) for R-phenylethyl propionate with excellent enantioselectivity (up to 97.3% ee) and without any activity loss during 14 days of operation.