4.8 Article

Highly enantioselective L-thiaproline catalyzed alpha-aminoxylation of aldehydes in aqueous media

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GREEN CHEMISTRY
卷 11, 期 4, 页码 543-547

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ROYAL SOC CHEMISTRY
DOI: 10.1039/b817950f

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  1. Ministry of Education, Singapore [ARC12/07, T206B3225]
  2. School of Physical and Mathematical Sciences
  3. Nanyang Technological University [RG53/07, RG140/06]

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Highly enantioselective L-thiaproline catalyzed alpha-aminoxylation of aldehydes in the presence of water and tetrabutylammonium bromide followed by in situ reduction to afford the respective alpha-aminoxy alcohols has been developed in good to high yields (74-88%) and excellent enantioselectivities (93-> 99%).

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