期刊
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 249, 期 10, 页码 1439-1448出版社
SPRINGER
DOI: 10.1007/s00417-011-1764-z
关键词
Retinal degenerative diseases; Stem cell therapy; Donor cells; Target cell types; Method of cell delivery; Potential risks; Clinical applications
资金
- NSFC/RGC [N_HKU 716/09]
- University of Hong Kong [201007176100]
With the development of stem cell technology, stem cell-based therapy for retinal degeneration has been proposed to restore the visual function. Many animal studies and some clinical trials have shown encouraging results of stem cell-based therapy in retinal degenerative diseases. While stem cell-based therapy is a promising strategy to replace damaged retinal cells and ultimately cure retinal degeneration, there are several important challenges which need to be overcome before stem cell technology can be applied widely in clinical settings. In this review, different types of donor cell origins used in retinal treatments, potential target cell types for therapy, methods of stem cell delivery to the eye, assessments of potential risks in stem cell therapy, as well as future developments of retinal stem cells therapy, will be discussed.
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