期刊
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 248, 期 1, 页码 59-63出版社
SPRINGER
DOI: 10.1007/s00417-009-1206-3
关键词
Baicalin; Lens; Ocular pharmacokinetics; Rabbit
This paper is to study the pharmacokinetic features of baicalin in lens through observing baicalin's concentration changes in lens of rabbits following intragastric administration. Forty-four rabbits were randomly divided into 11 groups. The lens were collected at the beginning without any intragastric administration, and then collected after 15 minutes following intragastric administration of 80 mg/kg baicalin, and continually collected individually after 0.5,0.75,1,1.5,2,3,5,8,12 hours: the concentration of baicalin was measured by reversed-phase high-performance liquid chromatography (RP-HPLC). There were two obvious peaks in the drug concentration-time diagram, appearing respectively at half an hour and 2 hours after the intragastric administration. The highest level of baicalin's concentration in lens (C (max) , = 4.997 mu g/ml) was obtained 0.9 hour (T (max) = 0.906 h) after application of baicalin. Area under the concentration time curve (AUC), half-life of the drug elimination (T (1/2) ) and clearance ratio were 3.542 A mu g/ml*h., 1.576 h and 8.114 l/h respectively. Baicalin can penetrate blood-eye barriers and enter the lens following intragastric administration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据