期刊
GLYCOCONJUGATE JOURNAL
卷 31, 期 6-7, 页码 461-467出版社
SPRINGER
DOI: 10.1007/s10719-014-9551-9
关键词
Heparan sulfate; Chondroitin sulfate; Glycosaminoglycans; Tumormetastasis; Tumor progression; RAGE
资金
- Japan Society for the Promotion of Science (JSPS) [23390016 20390019, 25670018]
- University Grants Commission [41-257-2012-SR]
- Vision Group Science and Technology, Department of Science and Technology [SR/FT/LS-142/2012]
- Karnataka University, INDIA
- Grants-in-Aid for Scientific Research [25670018] Funding Source: KAKEN
Various tumor cells exhibit structural alterations in the sulfated modifications to glycosaminoglycans (GAGs). The altered expression of chondroitin sulfate (CS) and heparan sulfate (HS) on the surfaces of tumor cells is known to play a key role in malignant transformation and tumor metastasis. The receptor molecule for the CS chains containing E-disaccharide units (CS-E) expressed on Lewis lung carcinoma (LLC) cells was recently revealed to be Receptor for Advanced Glycation End-products (RAGE). RAGE is also involved in the development of various pathological conditions including aging, infection, pulmonary fibrosis, diabetes, and Alzheimer's disease, by binding to a wide range of ligands. RAGE binds strongly not only to CS-E, but also to HS-expressing LLC cells. Recombinant RAGE bound CS-E and HS with high affinity. Furthermore, in a mouse model, the colonization of the lungs by LLC cells was inhibited by intravenously injected CS-E, an anti-CS-E antibody, or an anti-RAGE antibody. These findings demonstrated that RAGE is at least one of the critical receptors for CS and HS chains expressed on the tumor cell surface and is involved in experimental lung metastasis, and also that CS/HS and RAGE are potential molecular targets for the treatment of pulmonary metastasis. We, hence, reviewed these findings and also several chemically synthesized small GAGmimetics that exhibit potent anti-metastatic and/or anti-tumor activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据