期刊
GLYCOCONJUGATE JOURNAL
卷 29, 期 4, 页码 221-230出版社
SPRINGER
DOI: 10.1007/s10719-012-9400-7
关键词
Glycosidation; Leishmania; Gold catalysis; Orthoester; Lipophosphoglycan; Tetrasaccharide
资金
- Department of Science & Technology, New Delhi
- Council of Science & Industrial Research, New Delhi
Tetrasaccharide cap present in lipophosphoglycan of the Leishmania donovani responsible for visceral Leishmaniaisis is synthesized as a fully protected propargyl glycoside. AuBr3 mediated selective glycosylation of propargyl 1,2-orthoester in the presence of propargyl glycoside is employed as a key step to obtain propargyl containing oligomers. Further, propargyl tetrasaccharide is connected with a long chain hydrocarbon containing azidothiol functionality situated at two terminal ends via 'click' reaction.
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