期刊
GLYCOBIOLOGY
卷 24, 期 12, 页码 1283-+出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwu083
关键词
angiogenesis; galectin-1; galectins; glycosylation; hypoxia; immunotherapy; lectins; vasculature
资金
- Argentinean Agency for Promotion of Science and Technology (Ministry of Science and Technology)
- Argentinean National Council Research (CONICET)
- University of Buenos Aires
- Sales Foundation
Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, migration, metastasis and immune escape has been largely appreciated, our awareness of the impact of lectin-glycan recognition in tumor vascularization is relatively new. Regulated glycosylation can influence vascular biology by controlling trafficking, endocytosis and signaling of endothelial cell (EC) receptors including vascular endothelial growth factor receptors, platelet EC adhesion molecule, Notch and integrins. In addition, glycans may control angiogenesis by regulating migration of endothelial tip cells and influencing EC survival and vascular permeability. Recent evidence indicated that changes in the EC surface glycome may also serve on-and-off switches that control galectin binding to signaling receptors by displaying or masking-specific glycan epitopes. These glycosylation-dependent lectin-receptor interactions can link tumor hypoxia to EC signaling and control tumor sensitivity to anti-angiogenic treatment.
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