期刊
GLYCOBIOLOGY
卷 19, 期 8, 页码 816-828出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwp066
关键词
congenital muscular dystrophy; glycosylation; mannosyltransferase; O-mannosylation
资金
- Deutsche Forschungsgemeinschaft
- European Union
Protein O-mannosylation is an essential modification in fungi and animals. Different from most other types of O-glycosylation, protein O-mannosylation is initiated in the endoplasmic reticulum by the transfer of mannose from dolichol monophosphate-activated mannose to serine and threonine residues of secretory proteins. In recent years, it has emerged that even bacteria are capable of O-mannosylation and that the biosynthetic pathway of O-mannosyl glycans is conserved between pro- and eukaryotes. In this review, we summarize the observations that have opened up the field and highlight characteristics of O-mannosylation in the different domains/kingdoms of life.
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