期刊
GLYCOBIOLOGY
卷 19, 期 5, 页码 453-461出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwp004
关键词
6-sulfo sialyl Lewis X-capped O-glycan; alpha 1; 4-GlcNAc-capped O-glycan; cholesterol alpha-glucoside; cholesterol alpha-glucosyltransferase; Helicobacter pylori
资金
- National Cancer Institute
- National Institutes of Health [CA33000, CA71932]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [14082201, B-18790240]
- NATIONAL CANCER INSTITUTE [R01CA033000, R37CA033000, P01CA071932] Funding Source: NIH RePORTER
Helicobacter pylori is a Gram-negative bacterium that infects over 50% of the world's population. This organism causes various gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer. H. pylori possesses lipopolysaccharides that share structural similarity to Lewis blood group antigens in gastric mucosa. Such antigenic mimicry could result in immune tolerance against antigens of this pathogen. On the other hand, H. pylori colonizes gastric mucosa by utilizing adhesins that bind Lewis blood group antigen-related carbohydrates expressed on gastric epithelial cells. After colonization, H. pylori induces acute inflammatory responses mainly by neutrophils. This acute phase is gradually replaced by a chronic inflammatory response. In chronic gastritis, lymphocytes infiltrate the lamina propria, and such infiltration is facilitated by the interaction between L-selectin on lymphocytes and peripheral lymph node addressin (PNAd), which contains 6-sulfo sialyl Lewis X-capped O-glycans, on high endothelial venule (HEV)-like vessels. H. pylori barely colonizes gland mucous cell-derived mucin where alpha 1,4-GlcNAc-capped O-glycans exist. In vitro experiments show that alpha 1,4-GlcNAc-capped O-glycans function as a natural antibiotic to inhibit H. pylori growth. These findings show that distinct sets of carbohydrates expressed in the stomach are closely associated with pathogenesis and prevention of H. pylori-related diseases, providing therapeutic potentialities based on specific carbohydrate modulation.
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