期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 71, 期 10, 页码 1281-1288出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glv216
关键词
Carotid atherosclerosis; Coronary calcification; Physical fitness; Risk factor; Insulin-like growth factor-1
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [471872-2011-3]
- Fundacao de Apoio a Pesquisa do Distrito Federal [193.000.029-2012]
Our aim was to investigate whether physiological levels of soluble insulin-like growth factor-1 (IGF-1) associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old by means of a cross-sectional study including 100 community-dwelling individuals with no previous cardiovascular events. Linear correlation was found between IGF-1 and intima-media thickness, number of carotid plaques, and walking speed. Individuals in the upper IGF-1 tertile had smaller right and left intima-media thickness compared with the intermediate and lower tertiles, along with reduced atherosclerotic plaques. Also, walking speed was greater in the upper IGF-1 tertile. On the other hand, a nonlinear correlation was observed between IGF-1 and coronary calcification scores, with the intermediate IGF-1 tertile associated to the lowest scores of calcification and participants with lower circulating levels of IGF-1 showing higher frequency of high-risk morphology plaques. All in all, our report supports a territory-dependent, atherorefractory phenotype in the oldest old carrying middle and/or higher serum levels of IGF-1.
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