期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 71, 期 1, 页码 13-20出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glv206
关键词
Brain aging; Alzheimer's disease; Cerebrovasculature
资金
- American Heart Association
- National Center for Complementary and Alternative Medicine [R01-AT006526]
- National Institutes of Health [R01-AG047879, R01-AG038747, R01-NS056218]
- Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center [P30 AG028718]
- Oklahoma Center for the Advancement of Science and Technology
- Presbyterian Health Foundation
- COMAA
- Donald W. Reynolds Foundation
As the population of the Western world is aging, there is increasing awareness of age-related impairments in cognitive function and a rising interest in finding novel approaches to preserve cerebral health. A special collection of articles in The Journals of Gerontology: Biological Sciences and Medical Sciences brings together information of different aspects of brain aging, from latest developments in the field of neurodegenerative disorders to cerebral microvascular mechanisms of cognitive decline. It is emphasized that although the cellular changes that occur within aging neurons have been widely studied, more research is required as new signaling pathways are discovered that can potentially protect cells. New avenues for research targeting cellular senescence, epigenetics, and endocrine mechanisms of brain aging are also discussed. Based on the current literature it is clear that understanding brain aging and reducing risk for neurological disease with age requires searching for mechanisms and treatment options beyond the age-related changes in neuronal function. Thus, comprehensive approaches need to be developed that address the multiple, interrelated mechanisms of brain aging. Attention is brought to the importance of maintenance of cerebromicrovascular health, restoring neuroendocrine balance, and the pressing need for funding more innovative research into the interactions of neuronal, neuroendocrine, inflammatory and microvascular mechanisms of cognitive impairment, and Alzheimer's disease.
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